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122 related items for PubMed ID: 2400642

  • 1. Chemical synthesis, absolute configuration, and stereochemistry of formation of 10-hydroxywarfarin: a major oxidative metabolite of (+)-(R)-warfarin from hepatic microsomal preparations.
    Lawrence RF, Rettie AE, Eddy AC, Trager WF.
    Chirality; 1990; 2(2):96-105. PubMed ID: 2400642
    [Abstract] [Full Text] [Related]

  • 2. Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin.
    Kaminsky LS, Dunbar DA, Wang PP, Beaune P, Larrey D, Guengerich FP, Schnellmann RG, Sipes IG.
    Drug Metab Dispos; 1984; 12(4):470-7. PubMed ID: 6148215
    [Abstract] [Full Text] [Related]

  • 3. Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
    Bush ED, Trager WF.
    J Med Chem; 1985 Aug; 28(8):992-6. PubMed ID: 4020838
    [Abstract] [Full Text] [Related]

  • 4. Warfarin: stereochemical aspects of its metabolism in vivo in the rat.
    Pohl LR, Bales R, Trager WF.
    Res Commun Chem Pathol Pharmacol; 1976 Oct; 15(2):233-56. PubMed ID: 981784
    [Abstract] [Full Text] [Related]

  • 5. Phase II metabolism of warfarin in primary culture of adult rat hepatocytes.
    Jansing RL, Chao ES, Kaminsky LS.
    Mol Pharmacol; 1992 Jan; 41(1):209-15. PubMed ID: 1732719
    [Abstract] [Full Text] [Related]

  • 6. Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450.
    Darbyshire JF, Iyer KR, Grogan J, Korzekwa KR, Trager WF.
    Drug Metab Dispos; 1996 Sep; 24(9):1038-45. PubMed ID: 8886617
    [Abstract] [Full Text] [Related]

  • 7. Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products.
    Chang MS, Boeglin WE, Guengerich FP, Brash AR.
    Biochemistry; 1996 Jan 16; 35(2):464-71. PubMed ID: 8555216
    [Abstract] [Full Text] [Related]

  • 8. Characteristics of warfarin hydroxylation catalyzed by human liver microsomes.
    Rettie AE, Eddy AC, Heimark LD, Gibaldi M, Trager WF.
    Drug Metab Dispos; 1989 Jan 16; 17(3):265-70. PubMed ID: 2568906
    [Abstract] [Full Text] [Related]

  • 9. A new warfarin metabolite: structure and function.
    Fasco MJ, Dymerski PP, Wos JD, Kaminsky LS.
    J Med Chem; 1978 Oct 16; 21(10):1054-9. PubMed ID: 722713
    [Abstract] [Full Text] [Related]

  • 10. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T, Shiraga T, Mitani Y, Terakawa M, Tokuma Y, Kagayama A.
    Drug Metab Dispos; 2000 Sep 16; 28(9):1128-34. PubMed ID: 10950860
    [Abstract] [Full Text] [Related]

  • 11. Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe.
    Kaminsky LS, de Morais SM, Faletto MB, Dunbar DA, Goldstein JA.
    Mol Pharmacol; 1993 Feb 16; 43(2):234-9. PubMed ID: 8429826
    [Abstract] [Full Text] [Related]

  • 12. Selective inhibition of warfarin metabolism by diltiazem in humans.
    Abernethy DR, Kaminsky LS, Dickinson TH.
    J Pharmacol Exp Ther; 1991 Apr 16; 257(1):411-5. PubMed ID: 2020000
    [Abstract] [Full Text] [Related]

  • 13. Genetic and developmental diversity of hepatic cytochromes P450. Warfarin and progesterone metabolism by hepatic microsomes from four inbred strains of rat.
    Kitareewan S, Walz FG.
    Drug Metab Dispos; 1994 Apr 16; 22(4):607-15. PubMed ID: 7956737
    [Abstract] [Full Text] [Related]

  • 14. Simultaneous determination of warfarin enantiomers and its metabolite in human plasma by column-switching high-performance liquid chromatography with chiral separation.
    Uno T, Niioka T, Hayakari M, Sugawara K, Tateishi T.
    Ther Drug Monit; 2007 Jun 16; 29(3):333-9. PubMed ID: 17529891
    [Abstract] [Full Text] [Related]

  • 15. Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies.
    Kunze KL, Wienkers LC, Thummel KE, Trager WF.
    Drug Metab Dispos; 1996 Apr 16; 24(4):414-21. PubMed ID: 8801056
    [Abstract] [Full Text] [Related]

  • 16. Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin.
    Kim SY, Jones DR, Kang JY, Yun CH, Miller GP.
    Xenobiotica; 2019 Apr 16; 49(4):397-403. PubMed ID: 29543105
    [Abstract] [Full Text] [Related]

  • 17. Quantitative liquid chromatography/mass spectrometry/mass spectrometry warfarin assay for in vitro cytochrome P450 studies.
    Zhang ZY, King BM, Wong YN.
    Anal Biochem; 2001 Nov 01; 298(1):40-9. PubMed ID: 11673893
    [Abstract] [Full Text] [Related]

  • 18. Cytochrome P450 responsible for the stereoselective S-oxidation of flosequinan in hepatic microsomes from rats and humans.
    Kashiyama E, Yokoi T, Odomi M, Funae Y, Inoue K, Kamataki T.
    Drug Metab Dispos; 1997 Jun 01; 25(6):716-24. PubMed ID: 9193873
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of (S)-warfarin metabolism by sulfinpyrazone and its metabolites.
    He M, Kunze KL, Trager WF.
    Drug Metab Dispos; 1995 Jun 01; 23(6):659-63. PubMed ID: 7587949
    [Abstract] [Full Text] [Related]

  • 20. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.
    Jones DR, Kim SY, Guderyon M, Yun CH, Moran JH, Miller GP.
    Chem Res Toxicol; 2010 May 17; 23(5):939-45. PubMed ID: 20429590
    [Abstract] [Full Text] [Related]

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