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441 related items for PubMed ID: 24070586

  • 1. The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
    Du K, Williams CD, McGill MR, Xie Y, Farhood A, Vinken M, Jaeschke H.
    Toxicol Appl Pharmacol; 2013 Dec 15; 273(3):484-91. PubMed ID: 24070586
    [Abstract] [Full Text] [Related]

  • 2. Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
    Du K, Ramachandran A, Weemhoff JL, Chavan H, Xie Y, Krishnamurthy P, Jaeschke H.
    Toxicol Sci; 2016 Dec 15; 154(2):214-226. PubMed ID: 27562556
    [Abstract] [Full Text] [Related]

  • 3. Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
    Xie Y, Williams CD, McGill MR, Lebofsky M, Ramachandran A, Jaeschke H.
    Toxicol Sci; 2013 Jan 15; 131(1):325-35. PubMed ID: 22986947
    [Abstract] [Full Text] [Related]

  • 4. An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
    Park JH, Seo KS, Tadi S, Ahn BH, Lee JU, Heo JY, Han J, Song MS, Kim SH, Yim YH, Choi HS, Shong M, Kweon G.
    Antioxid Redox Signal; 2013 May 10; 18(14):1713-22. PubMed ID: 23121402
    [Abstract] [Full Text] [Related]

  • 5. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.
    Akakpo JY, Ramachandran A, Kandel SE, Ni HM, Kumer SC, Rumack BH, Jaeschke H.
    Hum Exp Toxicol; 2018 Dec 10; 37(12):1310-1322. PubMed ID: 29739258
    [Abstract] [Full Text] [Related]

  • 6. c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury.
    Win S, Than TA, Kaplowitz N.
    Antioxid Redox Signal; 2023 Jun 10; 38(16-18):1071-1081. PubMed ID: 36333933
    [Abstract] [Full Text] [Related]

  • 7. Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.
    Xie Y, Ramachandran A, Breckenridge DG, Liles JT, Lebofsky M, Farhood A, Jaeschke H.
    Toxicol Appl Pharmacol; 2015 Jul 01; 286(1):1-9. PubMed ID: 25818599
    [Abstract] [Full Text] [Related]

  • 8. Can acetaminophen/dimethyl sulfoxide formulation prevent accidental and intentional acetaminophen hepatotoxicity?
    Algfeley SG, Al-Rejaie SS, Nagi MN.
    Drug Dev Res; 2019 Jun 01; 80(4):475-480. PubMed ID: 30701566
    [Abstract] [Full Text] [Related]

  • 9. 4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
    Akakpo JY, Ramachandran A, Orhan H, Curry SC, Rumack BH, Jaeschke H.
    Toxicol Appl Pharmacol; 2020 Dec 15; 409():115317. PubMed ID: 33157119
    [Abstract] [Full Text] [Related]

  • 10. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.
    Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N.
    Gastroenterology; 2006 Jul 15; 131(1):165-78. PubMed ID: 16831600
    [Abstract] [Full Text] [Related]

  • 11. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
    Hu J, Ramshesh VK, McGill MR, Jaeschke H, Lemasters JJ.
    Toxicol Sci; 2016 Mar 15; 150(1):204-15. PubMed ID: 26721299
    [Abstract] [Full Text] [Related]

  • 12. Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation.
    Chowdhury A, Lu J, Zhang R, Nabila J, Gao H, Wan Z, Adelusi Temitope I, Yin X, Sun Y.
    Biomed Pharmacother; 2019 Sep 15; 117():109097. PubMed ID: 31212128
    [Abstract] [Full Text] [Related]

  • 13. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
    Saberi B, Ybanez MD, Johnson HS, Gaarde WA, Han D, Kaplowitz N.
    Hepatology; 2014 Apr 15; 59(4):1543-1554. PubMed ID: 23873604
    [Abstract] [Full Text] [Related]

  • 14. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.
    Du K, McGill MR, Xie Y, Jaeschke H.
    Food Chem Toxicol; 2015 Dec 15; 86():253-61. PubMed ID: 26522885
    [Abstract] [Full Text] [Related]

  • 15. Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity.
    Chowdhury A, Nabila J, Adelusi Temitope I, Wang S.
    Pharmacol Res; 2020 Nov 15; 161():105102. PubMed ID: 32738495
    [Abstract] [Full Text] [Related]

  • 16. Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
    Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y, Irie T.
    Pharmacol Res; 2014 Sep 15; 87():26-41. PubMed ID: 24951965
    [Abstract] [Full Text] [Related]

  • 17. Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning.
    Williams CD, McGill MR, Lebofsky M, Bajt ML, Jaeschke H.
    Toxicol Appl Pharmacol; 2014 Feb 01; 274(3):417-24. PubMed ID: 24345528
    [Abstract] [Full Text] [Related]

  • 18. Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.
    Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, Ding WX, Rumack BH, Jaeschke H.
    Toxicol Sci; 2019 Jul 01; 170(1):57-68. PubMed ID: 30903181
    [Abstract] [Full Text] [Related]

  • 19. Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice.
    Kim YH, Hwang JH, Kim KS, Noh JR, Choi DH, Kim DK, Tadi S, Yim YH, Choi HS, Lee CH.
    J Hepatol; 2015 Jul 01; 63(1):75-82. PubMed ID: 25681557
    [Abstract] [Full Text] [Related]

  • 20. Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice.
    Zhang J, Zhang S, Bi J, Gu J, Deng Y, Liu C.
    Int Immunopharmacol; 2017 Apr 01; 45():26-33. PubMed ID: 28152447
    [Abstract] [Full Text] [Related]

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