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Journal Abstract Search

208 related items for PubMed ID: 24074843

  • 1. Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
    Felts AS, Rodriguez AL, Morrison RD, Venable DF, Manka JT, Bates BS, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA.
    Bioorg Med Chem Lett; 2013 Nov 01; 23(21):5779-85. PubMed ID: 24074843
    [Abstract] [Full Text] [Related]

  • 2. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
    Bates BS, Rodriguez AL, Felts AS, Morrison RD, Venable DF, Blobaum AL, Byers FW, Lawson KP, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA.
    Bioorg Med Chem Lett; 2014 Aug 01; 24(15):3307-14. PubMed ID: 24969015
    [Abstract] [Full Text] [Related]

  • 3. Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.
    Rook JM, Tantawy MN, Ansari MS, Felts AS, Stauffer SR, Emmitte KA, Kessler RM, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ.
    Neuropsychopharmacology; 2015 Feb 01; 40(3):755-65. PubMed ID: 25241804
    [Abstract] [Full Text] [Related]

  • 4. The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
    Morrison RD, Blobaum AL, Byers FW, Santomango TS, Bridges TM, Stec D, Brewer KA, Sanchez-Ponce R, Corlew MM, Rush R, Felts AS, Manka J, Bates BS, Venable DF, Rodriguez AL, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2012 Sep 01; 40(9):1834-45. PubMed ID: 22711749
    [Abstract] [Full Text] [Related]

  • 5. Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.
    Butkiewicz M, Rodriguez AL, Rainey SE, Wieting J, Luscombe VB, Stauffer SR, Lindsley CW, Conn PJ, Meiler J.
    ACS Chem Neurosci; 2019 Aug 21; 10(8):3427-3436. PubMed ID: 31132237
    [Abstract] [Full Text] [Related]

  • 6. Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
    Hao J, Dehlinger V, Fivush AM, Rudyk HC, Britton TC, Hollinshead SP, Vokits BP, Clark BP, Henry SS, Massey SM, Peng L, Dressman BA, Heinz BA, Roberts EF, Bracey-Walker MR, Swanson S, Catlow JT, Love PL, Tepool AD, Peters SC, Simmons RM, Iyengar S, McKinzie DL, Monn JA.
    Bioorg Med Chem Lett; 2013 Mar 01; 23(5):1249-52. PubMed ID: 23374867
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  • 9. Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.
    Sengmany K, Hellyer SD, Albold S, Wang T, Conn PJ, May LT, Christopoulos A, Leach K, Gregory KJ.
    Neuropharmacology; 2019 May 01; 149():83-96. PubMed ID: 30763654
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  • 11. Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.
    Gould RW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW, Jones CK.
    Neuropsychopharmacology; 2016 Mar 01; 41(4):1166-78. PubMed ID: 26315507
    [Abstract] [Full Text] [Related]

  • 12. Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
    Packiarajan M, Grenon M, Zorn S, Hopper AT, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ.
    Bioorg Med Chem Lett; 2013 Jul 15; 23(14):4037-43. PubMed ID: 23770058
    [Abstract] [Full Text] [Related]

  • 13. Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
    Felts AS, Bollinger KA, Brassard CJ, Rodriguez AL, Morrison RD, Scott Daniels J, Blobaum AL, Niswender CM, Jones CK, Conn PJ, Emmitte KA, Lindsley CW.
    Bioorg Med Chem Lett; 2019 Jan 01; 29(1):47-50. PubMed ID: 30446311
    [Abstract] [Full Text] [Related]

  • 14. mGlu5-dependent modulation of anxiety during early withdrawal from binge-drinking in adult and adolescent male mice.
    Lee KM, Coelho MA, Class MA, Szumlinski KK.
    Drug Alcohol Depend; 2018 Mar 01; 184():1-11. PubMed ID: 29324247
    [Abstract] [Full Text] [Related]

  • 15. Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
    Parmentier-Batteur S, Hutson PH, Menzel K, Uslaner JM, Mattson BA, O'Brien JA, Magliaro BC, Forest T, Stump CA, Tynebor RM, Anthony NJ, Tucker TJ, Zhang XF, Gomez R, Huszar SL, Lambeng N, Fauré H, Le Poul E, Poli S, Rosahl TW, Rocher JP, Hargreaves R, Williams TM.
    Neuropharmacology; 2014 Jul 01; 82():161-73. PubMed ID: 23291536
    [Abstract] [Full Text] [Related]

  • 16. Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5.
    Arsova A, Møller TC, Vedel L, Hansen JL, Foster SR, Gregory KJ, Bräuner-Osborne H.
    Mol Pharmacol; 2020 Jul 01; 98(1):49-60. PubMed ID: 32358164
    [Abstract] [Full Text] [Related]

  • 17. Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors.
    Fu TT, Tu G, Ping M, Zheng GX, Yang FY, Yang JY, Zhang Y, Yao XJ, Xue WW, Zhu F.
    Acta Pharmacol Sin; 2021 Aug 01; 42(8):1354-1367. PubMed ID: 33122823
    [Abstract] [Full Text] [Related]

  • 18. 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.
    Felts AS, Lindsley SR, Lamb JP, Rodriguez AL, Menon UN, Jadhav S, Jones CK, Conn PJ, Lindsley CW, Emmitte KA.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4390-4. PubMed ID: 20598884
    [Abstract] [Full Text] [Related]

  • 19. Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition.
    Ellard JM, Madin A, Philps O, Hopkin M, Henderson S, Birch L, O'Connor D, Arai T, Takase K, Morgan L, Reynolds D, Talma S, Howley E, Powney B, Payne AH, Hall A, Gartlon JE, Dawson LA, Castro L, Atkinson PJ.
    Bioorg Med Chem Lett; 2015 Dec 15; 25(24):5792-6. PubMed ID: 26531152
    [Abstract] [Full Text] [Related]

  • 20. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators.
    Bennett KA, Christopher JA, Tehan BG.
    Adv Pharmacol; 2020 Dec 15; 88():35-58. PubMed ID: 32416871
    [Abstract] [Full Text] [Related]

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