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274 related items for PubMed ID: 24086147
1. Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling. Shaw JL, Chang KT. PLoS Genet; 2013; 9(9):e1003792. PubMed ID: 24086147 [Abstract] [Full Text] [Related]
2. Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome. Shaw JL, Zhang S, Chang KT. J Neurosci; 2015 Aug 12; 35(32):11374-83. PubMed ID: 26269644 [Abstract] [Full Text] [Related]
3. The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease. Lee S, Bang SM, Hong YK, Lee JH, Jeong H, Park SH, Liu QF, Lee IS, Cho KS. Dis Model Mech; 2016 Mar 12; 9(3):295-306. PubMed ID: 26659252 [Abstract] [Full Text] [Related]
4. Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein. Weaver C, Leidel C, Szpankowski L, Farley NM, Shubeita GT, Goldstein LS. Traffic; 2013 Mar 12; 14(3):295-308. PubMed ID: 23279138 [Abstract] [Full Text] [Related]
5. Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7. Wu Y, Deng Y, Zhang S, Luo Y, Cai F, Zhang Z, Zhou W, Li T, Song W. Neurobiol Aging; 2015 Jan 12; 36(1):169-77. PubMed ID: 25194880 [Abstract] [Full Text] [Related]
6. Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides. Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS. Hum Mol Genet; 2008 Nov 15; 17(22):3474-86. PubMed ID: 18694898 [Abstract] [Full Text] [Related]
7. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. J Clin Invest; 2016 May 02; 126(5):1815-33. PubMed ID: 27064279 [Abstract] [Full Text] [Related]
8. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Chang KT, Min KT. Proc Natl Acad Sci U S A; 2009 Oct 06; 106(40):17117-22. PubMed ID: 19805187 [Abstract] [Full Text] [Related]
9. Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease. Terwel D, Dewachter I, Van Leuven F. Neuromolecular Med; 2002 Oct 06; 2(2):151-65. PubMed ID: 12428809 [Abstract] [Full Text] [Related]
10. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S. Hum Mol Genet; 2000 Jul 01; 9(11):1681-90. PubMed ID: 10861295 [Abstract] [Full Text] [Related]
11. Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP. J Biol Chem; 2007 Oct 19; 282(42):30673-9. PubMed ID: 17693409 [Abstract] [Full Text] [Related]
12. RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta. Ermak G, Harris CD, Battocchio D, Davies KJ. FEBS J; 2006 May 19; 273(10):2100-9. PubMed ID: 16649988 [Abstract] [Full Text] [Related]
13. Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Xing L, Salas M, Zhang H, Gittler J, Ludwig T, Lin CS, Murty VV, Silverman W, Arancio O, Tycko B. Mamm Genome; 2013 Feb 19; 24(1-2):30-43. PubMed ID: 23096997 [Abstract] [Full Text] [Related]
14. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease. Ye X, Feng T, Tammineni P, Chang Q, Jeong YY, Margolis DJ, Cai H, Kusnecov A, Cai Q. J Neurosci; 2017 Mar 08; 37(10):2639-2655. PubMed ID: 28159908 [Abstract] [Full Text] [Related]
15. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease. Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E. J Neurosci Res; 2006 May 15; 83(7):1252-61. PubMed ID: 16511867 [Abstract] [Full Text] [Related]
16. Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallardó FV, Davies KJ, Viña J. J Alzheimers Dis; 2011 May 15; 27(4):701-9. PubMed ID: 21876249 [Abstract] [Full Text] [Related]
17. Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport. Dolma K, Iacobucci GJ, Hong Zheng K, Shandilya J, Toska E, White JA, Spina E, Gunawardena S. Hum Mol Genet; 2014 Mar 01; 23(5):1121-33. PubMed ID: 24105467 [Abstract] [Full Text] [Related]
18. Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model. Long ZM, Zhao L, Jiang R, Wang KJ, Luo SF, Zheng M, Li XF, He GQ. CNS Neurosci Ther; 2015 Nov 01; 21(11):887-97. PubMed ID: 26385876 [Abstract] [Full Text] [Related]
19. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Chang KT, Shi YJ, Min KT. Proc Natl Acad Sci U S A; 2003 Dec 23; 100(26):15794-9. PubMed ID: 14668437 [Abstract] [Full Text] [Related]
20. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Nature; 2009 Jun 25; 459(7250):1126-30. PubMed ID: 19458618 [Abstract] [Full Text] [Related] Page: [Next] [New Search]