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Journal Abstract Search

211 related items for PubMed ID: 24099149

  • 1. Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
    Younis Y, Douelle F, González Cabrera D, Le Manach C, Nchinda AT, Paquet T, Street LJ, White KL, Zabiulla KM, Joseph JT, Bashyam S, Waterson D, Witty MJ, Wittlin S, Charman SA, Chibale K.
    J Med Chem; 2013 Nov 14; 56(21):8860-71. PubMed ID: 24099149
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
    González Cabrera D, Douelle F, Younis Y, Feng TS, Le Manach C, Nchinda AT, Street LJ, Scheurer C, Kamber J, White KL, Montagnat OD, Ryan E, Katneni K, Zabiulla KM, Joseph JT, Bashyam S, Waterson D, Witty MJ, Charman SA, Wittlin S, Chibale K.
    J Med Chem; 2012 Dec 27; 55(24):11022-30. PubMed ID: 23189922
    [Abstract] [Full Text] [Related]

  • 3. 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential.
    Younis Y, Douelle F, Feng TS, González Cabrera D, Le Manach C, Nchinda AT, Duffy S, White KL, Shackleford DM, Morizzi J, Mannila J, Katneni K, Bhamidipati R, Zabiulla KM, Joseph JT, Bashyam S, Waterson D, Witty MJ, Hardick D, Wittlin S, Avery V, Charman SA, Chibale K.
    J Med Chem; 2012 Apr 12; 55(7):3479-87. PubMed ID: 22390538
    [Abstract] [Full Text] [Related]

  • 4. Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.
    Ongarora DS, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K.
    Bioorg Med Chem; 2015 Sep 01; 23(17):5419-32. PubMed ID: 26264839
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  • 6. Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.
    Lu WJ, Wicht KJ, Wang L, Imai K, Mei ZW, Kaiser M, El Sayed Iel T, Egan TJ, Inokuchi T.
    Eur J Med Chem; 2013 Jun 01; 64():498-511. PubMed ID: 23685569
    [Abstract] [Full Text] [Related]

  • 7. Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1.
    Le Manach C, Gonzàlez Cabrera D, Douelle F, Nchinda AT, Younis Y, Taylor D, Wiesner L, White KL, Ryan E, March C, Duffy S, Avery VM, Waterson D, Witty MJ, Wittlin S, Charman SA, Street LJ, Chibale K.
    J Med Chem; 2014 Mar 27; 57(6):2789-98. PubMed ID: 24568587
    [Abstract] [Full Text] [Related]

  • 8. Antimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.
    Paquet T, Gordon R, Waterson D, Witty MJ, Chibale K.
    Future Med Chem; 2012 Dec 27; 4(18):2265-77. PubMed ID: 23234550
    [Abstract] [Full Text] [Related]

  • 9. Metabolites of febrifugine and its synthetic analogue by mouse liver S9 and their antimalarial activity against Plasmodium malaria parasite.
    Hirai S, Kikuchi H, Kim HS, Begum K, Wataya Y, Tasaka H, Miyazawa Y, Yamamoto K, Oshima Y.
    J Med Chem; 2003 Sep 25; 46(20):4351-9. PubMed ID: 13678413
    [Abstract] [Full Text] [Related]

  • 10. N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.
    Ramachandran S, Hameed P S, Srivastava A, Shanbhag G, Morayya S, Rautela N, Awasthy D, Kavanagh S, Bharath S, Reddy J, Panduga V, Prabhakar KR, Saralaya R, Nanduri R, Raichurkar A, Menasinakai S, Achar V, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Waterson D, Lee MC, Coburn-Flynn O, Fidock DA, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK.
    J Med Chem; 2014 Aug 14; 57(15):6642-52. PubMed ID: 25007124
    [Abstract] [Full Text] [Related]

  • 11. Antimalarial and antiplasmodial activities of norneolignans. Syntheses and SAR.
    Skytte DM, Nielsen SF, Chen M, Zhai L, Olsen CE, Christensen SB.
    J Med Chem; 2006 Jan 12; 49(1):436-40. PubMed ID: 16392829
    [Abstract] [Full Text] [Related]

  • 12. Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
    Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.
    J Med Chem; 2008 Apr 10; 51(7):2170-7. PubMed ID: 18341274
    [Abstract] [Full Text] [Related]

  • 13. 4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.
    Joshi MC, Okombo J, Nsumiwa S, Ndove J, Taylor D, Wiesner L, Hunter R, Chibale K, Egan TJ.
    J Med Chem; 2017 Dec 28; 60(24):10245-10256. PubMed ID: 29185748
    [Abstract] [Full Text] [Related]

  • 14. Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle.
    Le Manach C, Nchinda AT, Paquet T, Gonzàlez Cabrera D, Younis Y, Han Z, Bashyam S, Zabiulla M, Taylor D, Lawrence N, White KL, Charman SA, Waterson D, Witty MJ, Wittlin S, Botha ME, Nondaba SH, Reader J, Birkholtz LM, Jiménez-Díaz MB, Martínez MS, Ferrer S, Angulo-Barturen I, Meister S, Antonova-Koch Y, Winzeler EA, Street LJ, Chibale K.
    J Med Chem; 2016 Nov 10; 59(21):9890-9905. PubMed ID: 27748596
    [Abstract] [Full Text] [Related]

  • 15. Discovery and optimisation studies of antimalarial phenotypic hits.
    Mital A, Murugesan D, Kaiser M, Yeates C, Gilbert IH.
    Eur J Med Chem; 2015 Oct 20; 103():530-8. PubMed ID: 26408453
    [Abstract] [Full Text] [Related]

  • 16. Novel orally active antimalarial thiazoles.
    González Cabrera D, Douelle F, Feng TS, Nchinda AT, Younis Y, White KL, Wu Q, Ryan E, Burrows JN, Waterson D, Witty MJ, Wittlin S, Charman SA, Chibale K.
    J Med Chem; 2011 Nov 10; 54(21):7713-9. PubMed ID: 21966980
    [Abstract] [Full Text] [Related]

  • 17. Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).
    Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ.
    J Med Chem; 2011 Oct 13; 54(19):6956-68. PubMed ID: 21875063
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
    Dong Y, Matile H, Chollet J, Kaminsky R, Wood JK, Vennerstrom JL.
    J Med Chem; 1999 Apr 22; 42(8):1477-80. PubMed ID: 10212135
    [Abstract] [Full Text] [Related]

  • 19. A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.
    Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K.
    J Med Chem; 2015 Nov 12; 58(21):8713-22. PubMed ID: 26502160
    [Abstract] [Full Text] [Related]

  • 20. Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides: a new class of antiplasmodial compounds.
    Leven M, Held J, Duffy S, Tschan S, Sax S, Kamber J, Frank W, Kuna K, Geffken D, Siethoff C, Barth S, Avery VM, Wittlin S, Mordmüller B, Kurz T.
    J Med Chem; 2014 Oct 09; 57(19):7971-6. PubMed ID: 25195945
    [Abstract] [Full Text] [Related]

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