These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways. Chen Y, Zheng L, Liu J, Zhou Z, Cao X, Lv X, Chen F. Int Immunopharmacol; 2014 Aug; 21(2):447-55. PubMed ID: 24905636 [Abstract] [Full Text] [Related]
3. Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway. Wang L, Tian Z, Yang Q, Li H, Guan H, Shi B, Hou P, Ji M. Oncotarget; 2015 Sep 22; 6(28):25917-31. PubMed ID: 26312762 [Abstract] [Full Text] [Related]
5. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Gong K, Li W. Free Radic Biol Med; 2011 Dec 15; 51(12):2259-71. PubMed ID: 22011623 [Abstract] [Full Text] [Related]
6. Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Wang CC, Chiang YM, Sung SC, Hsu YL, Chang JK, Kuo PL. Cancer Lett; 2008 Jan 18; 259(1):82-98. PubMed ID: 18023967 [Abstract] [Full Text] [Related]
7. Shikonin Inhibits the Migration and Invasion of Human Glioblastoma Cells by Targeting Phosphorylated β-Catenin and Phosphorylated PI3K/Akt: A Potential Mechanism for the Anti-Glioma Efficacy of a Traditional Chinese Herbal Medicine. Zhang FY, Hu Y, Que ZY, Wang P, Liu YH, Wang ZH, Xue YX. Int J Mol Sci; 2015 Oct 09; 16(10):23823-48. PubMed ID: 26473829 [Abstract] [Full Text] [Related]
8. Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis. Zhao X, Zhu Y, Hu J, Jiang L, Li L, Jia S, Zen K. Sci Rep; 2018 Sep 28; 8(1):14517. PubMed ID: 30266938 [Abstract] [Full Text] [Related]
9. Shikonin Inhibited Migration and Invasion of Human Lung Cancer Cells via Suppression of c-Met-Mediated Epithelial-to-Mesenchymal Transition. Hsieh YS, Liao CH, Chen WS, Pai JT, Weng MS. J Cell Biochem; 2017 Dec 28; 118(12):4639-4651. PubMed ID: 28485480 [Abstract] [Full Text] [Related]
10. Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling. Li MY, Mi C, Wang KS, Wang Z, Zuo HX, Piao LX, Xu GH, Li X, Ma J, Jin X. Chem Biol Interact; 2017 Aug 25; 274():58-67. PubMed ID: 28684144 [Abstract] [Full Text] [Related]
11. Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways. Wang JY, Wang Z, Li MY, Zhang Z, Mi C, Zuo HX, Xing Y, Wu YL, Lian LH, Xu GH, Piao LX, Ma J, Jin X. Chem Biol Interact; 2018 Dec 25; 296():134-144. PubMed ID: 30266538 [Abstract] [Full Text] [Related]
12. Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis. Ahn J, Won M, Choi JH, Kim YS, Jung CR, Im DS, Kyun ML, Lee K, Song KB, Chung KS. Apoptosis; 2013 Jul 25; 18(7):870-81. PubMed ID: 23546866 [Abstract] [Full Text] [Related]
13. Pien Tze Huang inhibits liver metastasis by targeting TGF-β signaling in an orthotopic model of colorectal cancer. Lin W, Zhuang Q, Zheng L, Cao Z, Shen A, Li Q, Fu C, Feng J, Peng J. Oncol Rep; 2015 Apr 25; 33(4):1922-8. PubMed ID: 25653118 [Abstract] [Full Text] [Related]
14. Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL‑6/STAT3 signaling pathway. Pan T, Zhang F, Li F, Gao X, Li Z, Li X, Ren X. Oncol Rep; 2020 Sep 25; 44(3):1049-1063. PubMed ID: 32705271 [Abstract] [Full Text] [Related]
15. Shikonin causes apoptosis by up-regulating p73 and down-regulating ICBP90 in human cancer cells. Jang SY, Hong D, Jeong SY, Kim JH. Biochem Biophys Res Commun; 2015 Sep 11; 465(1):71-6. PubMed ID: 26235879 [Abstract] [Full Text] [Related]
16. [Antitumor effect and mechanism of shikonin derivative SYUNZ-7]. Huang H, Xie BF, Zhu XF, Feng GK, Zhou JM, Wang Y, Wu HQ, Huang ZS, Gu LQ, Liu ZC. Ai Zheng; 2005 Dec 11; 24(12):1453-8. PubMed ID: 16351791 [Abstract] [Full Text] [Related]
17. Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway. Jia L, Zhu Z, Li H, Li Y. Artif Cells Nanomed Biotechnol; 2019 Dec 11; 47(1):2662-2669. PubMed ID: 31257936 [Abstract] [Full Text] [Related]
18. Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling. Qu D, Xu XM, Zhang M, Jiang TS, Zhang Y, Li SQ. Mol Med Rep; 2015 Jul 11; 12(1):1305-13. PubMed ID: 25815461 [Abstract] [Full Text] [Related]
19. Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer. Munagala R, Aqil F, Jeyabalan J, Gupta RC. Cancer Lett; 2015 Jan 28; 356(2 Pt B):536-46. PubMed ID: 25304375 [Abstract] [Full Text] [Related]
20. Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells. Tang Q, Liu L, Zhang H, Xiao J, Hann SS. Drug Des Devel Ther; 2020 Jan 28; 14():577-589. PubMed ID: 32103900 [Abstract] [Full Text] [Related] Page: [Next] [New Search]