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292 related items for PubMed ID: 24115156

  • 1. Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins.
    Moad HE, Pioszak AA.
    Protein Sci; 2013 Dec; 22(12):1775-85. PubMed ID: 24115156
    [Abstract] [Full Text] [Related]

  • 2. Structure-function analyses reveal a triple β-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design.
    Roehrkasse AM, Booe JM, Lee SM, Warner ML, Pioszak AA.
    J Biol Chem; 2018 Oct 12; 293(41):15840-15854. PubMed ID: 30139742
    [Abstract] [Full Text] [Related]

  • 3. Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
    Watkins HA, Walker CS, Ly KN, Bailey RJ, Barwell J, Poyner DR, Hay DL.
    Br J Pharmacol; 2014 Feb 12; 171(3):772-88. PubMed ID: 24199627
    [Abstract] [Full Text] [Related]

  • 4. Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.
    Woolley MJ, Reynolds CA, Simms J, Walker CS, Mobarec JC, Garelja ML, Conner AC, Poyner DR, Hay DL.
    Biochem Pharmacol; 2017 Oct 15; 142():96-110. PubMed ID: 28705698
    [Abstract] [Full Text] [Related]

  • 5. Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.
    Booe JM, Warner ML, Roehrkasse AM, Hay DL, Pioszak AA.
    Mol Pharmacol; 2018 Apr 15; 93(4):355-367. PubMed ID: 29363552
    [Abstract] [Full Text] [Related]

  • 6. Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor.
    Babin KM, Karim JA, Gordon PH, Lennon J, Dickson A, Pioszak AA.
    J Biol Chem; 2023 Jun 15; 299(6):104785. PubMed ID: 37146967
    [Abstract] [Full Text] [Related]

  • 7. Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling.
    Hill HE, Pioszak AA.
    Protein Expr Purif; 2013 Mar 15; 88(1):107-13. PubMed ID: 23247088
    [Abstract] [Full Text] [Related]

  • 8. Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
    Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA.
    Mol Cell; 2015 Jun 18; 58(6):1040-52. PubMed ID: 25982113
    [Abstract] [Full Text] [Related]

  • 9. Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
    Lee SM, Hay DL, Pioszak AA.
    J Biol Chem; 2016 Apr 15; 291(16):8686-700. PubMed ID: 26895962
    [Abstract] [Full Text] [Related]

  • 10. Ectodomain structures of the CGRP and AM receptors.
    Kusano S, Yokoyama S.
    Curr Protein Pept Sci; 2013 Aug 15; 14(5):375-85. PubMed ID: 23745701
    [Abstract] [Full Text] [Related]

  • 11. Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: The inhibitory role of receptor N-glycosylation.
    Lee S.
    Peptides; 2022 Apr 15; 150():170735. PubMed ID: 35007660
    [Abstract] [Full Text] [Related]

  • 12. Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice.
    Pawlak JB, Wetzel-Strong SE, Dunn MK, Caron KM.
    Peptides; 2017 Feb 15; 88():1-7. PubMed ID: 27940069
    [Abstract] [Full Text] [Related]

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  • 14. The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling.
    Kuwasako K, Hay DL, Nagata S, Hikosaka T, Kitamura K, Kato J.
    Br J Pharmacol; 2012 May 15; 166(1):137-50. PubMed ID: 22142144
    [Abstract] [Full Text] [Related]

  • 15. Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: INSIGHTS INTO THE MOLECULAR AND FUNCTIONAL EVOLUTION IN CHORDATES.
    Sekiguchi T, Kuwasako K, Ogasawara M, Takahashi H, Matsubara S, Osugi T, Muramatsu I, Sasayama Y, Suzuki N, Satake H.
    J Biol Chem; 2016 Jan 29; 291(5):2345-56. PubMed ID: 26644465
    [Abstract] [Full Text] [Related]

  • 16. Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
    Watkins HA, Chakravarthy M, Abhayawardana RS, Gingell JJ, Garelja M, Pardamwar M, McElhinney JM, Lathbridge A, Constantine A, Harris PW, Yuen TY, Brimble MA, Barwell J, Poyner DR, Woolley MJ, Conner AC, Pioszak AA, Reynolds CA, Hay DL.
    J Biol Chem; 2016 May 27; 291(22):11657-75. PubMed ID: 27013657
    [Abstract] [Full Text] [Related]

  • 17. Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activity.
    Kunz TH, Scott M, Ittner LM, Fischer JA, Born W, Vogel J.
    Am J Physiol Heart Circ Physiol; 2007 Oct 27; 293(4):H2155-60. PubMed ID: 17660394
    [Abstract] [Full Text] [Related]

  • 18. Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3.
    Robinson SD, Aitken JF, Bailey RJ, Poyner DR, Hay DL.
    J Pharmacol Exp Ther; 2009 Nov 27; 331(2):513-21. PubMed ID: 19644039
    [Abstract] [Full Text] [Related]

  • 19. Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole.
    Nag K, Sultana N, Kato A, Dranik A, Nakamura N, Kutsuzawa K, Hirose S, Akaike T.
    Gen Comp Endocrinol; 2015 Feb 01; 212():156-62. PubMed ID: 24815888
    [Abstract] [Full Text] [Related]

  • 20. Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins.
    Hilairet S, Foord SM, Marshall FH, Bouvier M.
    J Biol Chem; 2001 Aug 03; 276(31):29575-81. PubMed ID: 11387328
    [Abstract] [Full Text] [Related]

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