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Journal Abstract Search

114 related items for PubMed ID: 24138939

  • 1. Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.
    Illig CR, Manthey CL, Meegalla SK, Wall MJ, Chen J, Wilson KJ, DesJarlais RL, Ballentine SK, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Donatelli RR, Yurkow E, Zhou Z, Player MR, Tomczuk BE.
    Bioorg Med Chem Lett; 2013 Dec 01; 23(23):6363-9. PubMed ID: 24138939
    [Abstract] [Full Text] [Related]

  • 2. Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.
    Wilson KJ, Illig CR, Chen J, Wall MJ, Ballentine SK, DesJarlais RL, Chen Y, Schubert C, Donatelli R, Petrounia I, Crysler CS, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Meegalla SK.
    Bioorg Med Chem Lett; 2010 Jul 01; 20(13):3925-9. PubMed ID: 20570147
    [Abstract] [Full Text] [Related]

  • 3. 3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
    Scott DA, Dakin LA, Del Valle DJ, Diebold RB, Drew L, Gero TW, Ogoe CA, Omer CA, Repik G, Thakur K, Ye Q, Zheng X.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1382-4. PubMed ID: 21295474
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors.
    Wall MJ, Chen J, Meegalla S, Ballentine SK, Wilson KJ, DesJarlais RL, Schubert C, Chaikin MA, Crysler C, Petrounia IP, Donatelli RR, Yurkow EJ, Boczon L, Mazzulla M, Player MR, Patch RJ, Manthey CL, Molloy C, Tomczuk B, Illig CR.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2097-102. PubMed ID: 18289848
    [Abstract] [Full Text] [Related]

  • 5. Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
    Illig CR, Manthey CL, Wall MJ, Meegalla SK, Chen J, Wilson KJ, Ballentine SK, Desjarlais RL, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Donatelli RR, Yurkow E, Zhou Z, Player MR, Tomczuk BE.
    J Med Chem; 2011 Nov 24; 54(22):7860-83. PubMed ID: 22039836
    [Abstract] [Full Text] [Related]

  • 6. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.
    Illig CR, Chen J, Wall MJ, Wilson KJ, Ballentine SK, Rudolph MJ, DesJarlais RL, Chen Y, Schubert C, Petrounia I, Crysler CS, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Meegalla SK.
    Bioorg Med Chem Lett; 2008 Mar 01; 18(5):1642-8. PubMed ID: 18242992
    [Abstract] [Full Text] [Related]

  • 7. Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
    DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X.
    J Med Chem; 2008 Mar 27; 51(6):1681-94. PubMed ID: 18321037
    [Abstract] [Full Text] [Related]

  • 8. Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
    Huang H, Hutta DA, Rinker JM, Hu H, Parsons WH, Schubert C, DesJarlais RL, Crysler CS, Chaikin MA, Donatelli RR, Chen Y, Cheng D, Zhou Z, Yurkow E, Manthey CL, Player MR.
    J Med Chem; 2009 Feb 26; 52(4):1081-99. PubMed ID: 19193011
    [Abstract] [Full Text] [Related]

  • 9. Cell-based biological evaluation of a new bisamide FMS kinase inhibitor possessing pyrrolo[3,2-c]pyridine scaffold.
    El-Gamal MI, Abdel-Maksoud MS, El-Din MM, Yoo KH, Baek D, Oh CH.
    Arch Pharm (Weinheim); 2014 Sep 26; 347(9):635-41. PubMed ID: 24942978
    [Abstract] [Full Text] [Related]

  • 10. Discovery of a new potent bisamide FMS kinase inhibitor.
    El-Gamal MI, Jung MH, Oh CH.
    Bioorg Med Chem Lett; 2010 Jun 01; 20(11):3216-8. PubMed ID: 20457522
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  • 18. The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain.
    Walter M, Lucet IS, Patel O, Broughton SE, Bamert R, Williams NK, Fantino E, Wilks AF, Rossjohn J.
    J Mol Biol; 2007 Mar 30; 367(3):839-47. PubMed ID: 17292918
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  • 20. Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
    Mashkani B, Griffith R, Ashman LK.
    Bioorg Med Chem; 2010 Mar 01; 18(5):1789-97. PubMed ID: 20156689
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