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Journal Abstract Search

274 related items for PubMed ID: 24243565

  • 1. Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts.
    Ingels A, Zhao H, Thong AE, Saar M, Valta MP, Nolley R, Santos J, Peehl DM.
    Int J Cancer; 2014 May 15; 134(10):2322-9. PubMed ID: 24243565
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  • 2. Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models.
    Gökmen-Polar Y, Liu Y, Toroni RA, Sanders KL, Mehta R, Badve S, Rommel C, Sledge GW.
    Breast Cancer Res Treat; 2012 Dec 15; 136(3):673-82. PubMed ID: 23085766
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  • 3. MLN0128, an ATP-competitive mTOR kinase inhibitor with potent in vitro and in vivo antitumor activity, as potential therapy for bone and soft-tissue sarcoma.
    Slotkin EK, Patwardhan PP, Vasudeva SD, de Stanchina E, Tap WD, Schwartz GK.
    Mol Cancer Ther; 2015 Feb 15; 14(2):395-406. PubMed ID: 25519700
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  • 5. Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors.
    Hassan B, Akcakanat A, Sangai T, Evans KW, Adkins F, Eterovic AK, Zhao H, Chen K, Chen H, Do KA, Xie SM, Holder AM, Naing A, Mills GB, Meric-Bernstam F.
    Oncotarget; 2014 Sep 30; 5(18):8544-57. PubMed ID: 25261369
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  • 6. Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.
    Harada K, Miyake H, Kumano M, Fujisawa M.
    Br J Cancer; 2013 Oct 29; 109(9):2389-95. PubMed ID: 24091619
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  • 7. Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis.
    Guo Y, Kwiatkowski DJ.
    Mol Cancer Res; 2013 May 29; 11(5):467-73. PubMed ID: 23386687
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  • 11. Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth.
    Kannan A, Lin Z, Shao Q, Zhao S, Fang B, Moreno MA, Vural E, Stack BC, Suen JY, Kannan K, Gao L.
    Oncotarget; 2016 Feb 09; 7(6):6576-92. PubMed ID: 26536665
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  • 13. Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma.
    Caro-Vegas C, Bailey A, Bigi R, Damania B, Dittmer DP.
    mBio; 2019 Feb 19; 10(1):. PubMed ID: 30782662
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  • 14. The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent.
    Xiong Z, Zang Y, Zhong S, Zou L, Wu Y, Liu S, Fang Z, Shen Z, Ding Q, Chen S.
    Oncotarget; 2017 May 02; 8(18):30151-30161. PubMed ID: 28404914
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  • 15. MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells.
    Zeng Z, Wang RY, Qiu YH, Mak DH, Coombes K, Yoo SY, Zhang Q, Jessen K, Liu Y, Rommel C, Fruman DA, Kantarjian HM, Kornblau SM, Andreeff M, Konopleva M.
    Oncotarget; 2016 Aug 23; 7(34):55083-55097. PubMed ID: 27391151
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  • 16. The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma.
    Cho DC, Cohen MB, Panka DJ, Collins M, Ghebremichael M, Atkins MB, Signoretti S, Mier JW.
    Clin Cancer Res; 2010 Jul 15; 16(14):3628-38. PubMed ID: 20606035
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  • 17. The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma.
    Miyahara H, Yadavilli S, Natsumeda M, Rubens JA, Rodgers L, Kambhampati M, Taylor IC, Kaur H, Asnaghi L, Eberhart CG, Warren KE, Nazarian J, Raabe EH.
    Cancer Lett; 2017 Aug 01; 400():110-116. PubMed ID: 28450157
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  • 18. Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways.
    Liu QJ, Shen HL, Lin J, Xu XH, Ji ZG, Han X, Shang DH, Yang PQ.
    Drug Des Devel Ther; 2016 Aug 01; 10():745-55. PubMed ID: 26937175
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  • 19. A phase I study of temsirolimus and bryostatin-1 in patients with metastatic renal cell carcinoma and soft tissue sarcoma.
    Plimack ER, Tan T, Wong YN, von Mehren MM, Malizzia L, Roethke SK, Litwin S, Li T, Hudes GR, Haas NB.
    Oncologist; 2014 Apr 01; 19(4):354-5. PubMed ID: 24674872
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  • 20. mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms.
    Wilson-Edell KA, Yevtushenko MA, Rothschild DE, Rogers AN, Benz CC.
    Breast Cancer Res Treat; 2014 Apr 01; 144(2):287-298. PubMed ID: 24562770
    [Abstract] [Full Text] [Related]

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