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Journal Abstract Search

425 related items for PubMed ID: 24275666

  • 1. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.
    Chen Y, Wei H, Liu F, Guan JL.
    J Biol Chem; 2014 Jan 10; 289(2):1164-73. PubMed ID: 24275666
    [Abstract] [Full Text] [Related]

  • 2. Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).
    Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS.
    J Biol Chem; 2014 Sep 05; 289(36):25227-40. PubMed ID: 24990947
    [Abstract] [Full Text] [Related]

  • 3. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.
    Copps KD, Hançer NJ, Qiu W, White MF.
    J Biol Chem; 2016 Apr 15; 291(16):8602-17. PubMed ID: 26846849
    [Abstract] [Full Text] [Related]

  • 4. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
    Menon S, Yecies JL, Zhang HH, Howell JJ, Nicholatos J, Harputlugil E, Bronson RT, Kwiatkowski DJ, Manning BD.
    Sci Signal; 2012 Mar 27; 5(217):ra24. PubMed ID: 22457330
    [Abstract] [Full Text] [Related]

  • 5. mTORC2 is required for proliferation and survival of TSC2-null cells.
    Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP.
    Mol Cell Biol; 2011 Jun 27; 31(12):2484-98. PubMed ID: 21482669
    [Abstract] [Full Text] [Related]

  • 6. Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance.
    Hegazy AM, Yamada D, Kobayashi M, Kohno S, Ueno M, Ali MA, Ohta K, Tadokoro Y, Ino Y, Todo T, Soga T, Takahashi C, Hirao A.
    J Biol Chem; 2016 Oct 07; 291(41):21496-21509. PubMed ID: 27519418
    [Abstract] [Full Text] [Related]

  • 7. Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells.
    Alayev A, Sun Y, Snyder RB, Berger SM, Yu JJ, Holz MK.
    Cell Cycle; 2014 Oct 07; 13(3):371-82. PubMed ID: 24304514
    [Abstract] [Full Text] [Related]

  • 8. p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
    Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H.
    J Biol Chem; 2014 Feb 14; 289(7):4083-94. PubMed ID: 24366874
    [Abstract] [Full Text] [Related]

  • 9. Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin.
    Yang J, Kalogerou M, Samsel PA, Zhang Y, Griffiths DF, Gallacher J, Sampson JR, Shen MH.
    Oncogene; 2015 Feb 12; 34(7):922-31. PubMed ID: 24632604
    [Abstract] [Full Text] [Related]

  • 10. Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift.
    Medvetz D, Priolo C, Henske EP.
    Mol Cancer Res; 2015 Jan 12; 13(1):3-8. PubMed ID: 25298408
    [Abstract] [Full Text] [Related]

  • 11. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.
    Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM.
    Autophagy; 2014 Feb 12; 10(2):226-42. PubMed ID: 24296537
    [Abstract] [Full Text] [Related]

  • 12. SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway.
    Gen Y, Yasui K, Nishikawa T, Yoshikawa T.
    Cancer Sci; 2013 Jul 12; 104(7):810-6. PubMed ID: 23510069
    [Abstract] [Full Text] [Related]

  • 13. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
    Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan KL, Shrager JB.
    Sci Signal; 2014 Feb 25; 7(314):ra18. PubMed ID: 24570486
    [Abstract] [Full Text] [Related]

  • 14. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
    Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.
    J Biol Chem; 2014 Oct 24; 289(43):29739-49. PubMed ID: 25164809
    [Abstract] [Full Text] [Related]

  • 15. TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome.
    Venkatesh A, Ma S, Punzo C.
    Cell Death Dis; 2016 Jun 30; 7(6):e2279. PubMed ID: 27362797
    [Abstract] [Full Text] [Related]

  • 16. Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy.
    Huang H, Kang R, Wang J, Luo G, Yang W, Zhao Z.
    Autophagy; 2013 Feb 01; 9(2):175-95. PubMed ID: 23169238
    [Abstract] [Full Text] [Related]

  • 17. Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.
    Bommer UA, Iadevaia V, Chen J, Knoch B, Engel M, Proud CG.
    Cell Signal; 2015 Aug 01; 27(8):1557-68. PubMed ID: 25936523
    [Abstract] [Full Text] [Related]

  • 18. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.
    Cell Signal; 2014 Mar 01; 26(3):461-7. PubMed ID: 24316235
    [Abstract] [Full Text] [Related]

  • 19. Akt and mTORC1 have different roles during liver tumorigenesis in mice.
    Kenerson HL, Yeh MM, Kazami M, Jiang X, Riehle KJ, McIntyre RL, Park JO, Kwon S, Campbell JS, Yeung RS.
    Gastroenterology; 2013 May 01; 144(5):1055-65. PubMed ID: 23376645
    [Abstract] [Full Text] [Related]

  • 20. Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.
    Ou X, Liu M, Luo H, Dong LQ, Liu F.
    PLoS One; 2014 May 01; 9(4):e95393. PubMed ID: 24740400
    [Abstract] [Full Text] [Related]

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