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Journal Abstract Search

262 related items for PubMed ID: 24294969

  • 1. Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
    Hua Z, Bregman H, Buchanan JL, Chakka N, Guzman-Perez A, Gunaydin H, Huang X, Gu Y, Berry V, Liu J, Teffera Y, Huang L, Egge B, Emkey R, Mullady EL, Schneider S, Andrews PS, Acquaviva L, Dovey J, Mishra A, Newcomb J, Saffran D, Serafino R, Strathdee CA, Turci SM, Stanton M, Wilson C, Dimauro EF.
    J Med Chem; 2013 Dec 27; 56(24):10003-15. PubMed ID: 24294969
    [Abstract] [Full Text] [Related]

  • 2. Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
    Bregman H, Chakka N, Guzman-Perez A, Gunaydin H, Gu Y, Huang X, Berry V, Liu J, Teffera Y, Huang L, Egge B, Mullady EL, Schneider S, Andrews PS, Mishra A, Newcomb J, Serafino R, Strathdee CA, Turci SM, Wilson C, DiMauro EF.
    J Med Chem; 2013 Jun 13; 56(11):4320-42. PubMed ID: 23701517
    [Abstract] [Full Text] [Related]

  • 3. Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
    Shultz MD, Cheung AK, Kirby CA, Firestone B, Fan J, Chen CH, Chen Z, Chin DN, Dipietro L, Fazal A, Feng Y, Fortin PD, Gould T, Lagu B, Lei H, Lenoir F, Majumdar D, Ochala E, Palermo MG, Pham L, Pu M, Smith T, Stams T, Tomlinson RC, Touré BB, Visser M, Wang RM, Waters NJ, Shao W.
    J Med Chem; 2013 Aug 22; 56(16):6495-511. PubMed ID: 23844574
    [Abstract] [Full Text] [Related]

  • 4. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.
    Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M.
    Cancer Res; 2013 May 15; 73(10):3132-44. PubMed ID: 23539443
    [Abstract] [Full Text] [Related]

  • 5. Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.
    Buchstaller HP, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, Musil D, Radtki D, Ritzert C, Rohdich F, Schneider R, Esdar C.
    J Med Chem; 2019 Sep 12; 62(17):7897-7909. PubMed ID: 31381853
    [Abstract] [Full Text] [Related]

  • 6. Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.
    Bregman H, Gunaydin H, Gu Y, Schneider S, Wilson C, DiMauro EF, Huang X.
    J Med Chem; 2013 Feb 14; 56(3):1341-5. PubMed ID: 23316926
    [Abstract] [Full Text] [Related]

  • 7. Insights of tankyrases: A novel target for drug discovery.
    Damale MG, Pathan SK, Shinde DB, Patil RH, Arote RB, Sangshetti JN.
    Eur J Med Chem; 2020 Dec 01; 207():112712. PubMed ID: 32877803
    [Abstract] [Full Text] [Related]

  • 8. Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.
    Kirubakaran P, Kothandan G, Cho SJ, Muthusamy K.
    Mol Biosyst; 2014 Feb 01; 10(2):281-93. PubMed ID: 24291818
    [Abstract] [Full Text] [Related]

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  • 10. Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer.
    Shirai F, Mizutani A, Yashiroda Y, Tsumura T, Kano Y, Muramatsu Y, Chikada T, Yuki H, Niwa H, Sato S, Washizuka K, Koda Y, Mazaki Y, Jang MK, Yoshida H, Nagamori A, Okue M, Watanabe T, Kitamura K, Shitara E, Honma T, Umehara T, Shirouzu M, Fukami T, Seimiya H, Yoshida M, Koyama H.
    J Med Chem; 2020 Apr 23; 63(8):4183-4204. PubMed ID: 32202790
    [Abstract] [Full Text] [Related]

  • 11. RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
    Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    Cancer Sci; 2018 Dec 23; 109(12):4003-4014. PubMed ID: 30238564
    [Abstract] [Full Text] [Related]

  • 12. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
    Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L.
    J Med Chem; 2013 Oct 24; 56(20):7880-9. PubMed ID: 24116873
    [Abstract] [Full Text] [Related]

  • 13. Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta.
    Martino-Echarri E, Brocardo MG, Mills KM, Henderson BR.
    PLoS One; 2016 Oct 24; 11(3):e0150484. PubMed ID: 26930278
    [Abstract] [Full Text] [Related]

  • 14. Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
    Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H.
    J Med Chem; 2019 Apr 11; 62(7):3407-3427. PubMed ID: 30883102
    [Abstract] [Full Text] [Related]

  • 15. Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.
    Nkizinkiko Y, Suneel Kumar BVS, Jeankumar VU, Haikarainen T, Koivunen J, Madhuri C, Yogeeswari P, Venkannagari H, Obaji E, Pihlajaniemi T, Sriram D, Lehtiö L.
    Bioorg Med Chem; 2015 Aug 01; 23(15):4139-4149. PubMed ID: 26183543
    [Abstract] [Full Text] [Related]

  • 16. Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library.
    Samain F, Ekblad T, Mikutis G, Zhong N, Zimmermann M, Nauer A, Bajic D, Decurtins W, Scheuermann J, Brown PJ, Hall J, Gräslund S, Schüler H, Neri D, Franzini RM.
    J Med Chem; 2015 Jun 25; 58(12):5143-9. PubMed ID: 26061013
    [Abstract] [Full Text] [Related]

  • 17. Novel binding mode of a potent and selective tankyrase inhibitor.
    Gunaydin H, Gu Y, Huang X.
    PLoS One; 2012 Jun 25; 7(3):e33740. PubMed ID: 22438990
    [Abstract] [Full Text] [Related]

  • 18. Tankyrases as drug targets.
    Lehtiö L, Chi NW, Krauss S.
    FEBS J; 2013 Aug 25; 280(15):3576-93. PubMed ID: 23648170
    [Abstract] [Full Text] [Related]

  • 19. para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors.
    Haikarainen T, Koivunen J, Narwal M, Venkannagari H, Obaji E, Joensuu P, Pihlajaniemi T, Lehtiö L.
    ChemMedChem; 2013 Dec 25; 8(12):1978-85. PubMed ID: 24130191
    [Abstract] [Full Text] [Related]

  • 20. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
    Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S.
    Cancer Res; 2012 Jun 01; 72(11):2822-32. PubMed ID: 22440753
    [Abstract] [Full Text] [Related]

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