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162 related items for PubMed ID: 24406249

  • 1. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
    Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2014 Feb 15; 87(4):611-24. PubMed ID: 24406249
    [Abstract] [Full Text] [Related]

  • 2. Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
    Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM.
    Invest New Drugs; 2016 Oct 15; 34(5):663-76. PubMed ID: 27334143
    [Abstract] [Full Text] [Related]

  • 3. Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
    Bright SA, Campiani G, Deininger MW, Lawler M, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2010 Jul 01; 80(1):31-8. PubMed ID: 20206141
    [Abstract] [Full Text] [Related]

  • 4. The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15.
    Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM.
    Invest New Drugs; 2016 Apr 01; 34(2):159-67. PubMed ID: 26885657
    [Abstract] [Full Text] [Related]

  • 5. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.
    Bright SA, Greene LM, Greene TF, Campiani G, Butini S, Brindisi M, Lawler M, Meegan MJ, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2009 Feb 01; 77(3):310-21. PubMed ID: 19014913
    [Abstract] [Full Text] [Related]

  • 6. STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
    Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM.
    J Pharmacol Exp Ther; 2007 Apr 01; 321(1):288-97. PubMed ID: 17202400
    [Abstract] [Full Text] [Related]

  • 7. Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
    Mc Gee MM, Greene LM, Ledwidge S, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM.
    J Pharmacol Exp Ther; 2004 Sep 01; 310(3):1084-95. PubMed ID: 15143129
    [Abstract] [Full Text] [Related]

  • 8. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
    Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Cancer Chemother Pharmacol; 2010 Aug 01; 66(3):585-96. PubMed ID: 20020128
    [Abstract] [Full Text] [Related]

  • 9. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
    Nathwani SM, Cloonan SM, Stronach M, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Oncol Rep; 2010 Dec 01; 24(6):1499-507. PubMed ID: 21042745
    [Abstract] [Full Text] [Related]

  • 10. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
    Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM.
    Mol Pharmacol; 2006 Jul 01; 70(1):60-70. PubMed ID: 16571652
    [Abstract] [Full Text] [Related]

  • 11. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
    McElligott AM, Maginn EN, Greene LM, McGuckin S, Hayat A, Browne PV, Butini S, Campiani G, Catherwood MA, Vandenberghe E, Williams DC, Zisterer DM, Lawler M.
    Cancer Res; 2009 Nov 01; 69(21):8366-75. PubMed ID: 19826055
    [Abstract] [Full Text] [Related]

  • 12. The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells.
    Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM.
    Int J Oncol; 2016 Jul 01; 49(1):74-88. PubMed ID: 27176505
    [Abstract] [Full Text] [Related]

  • 13. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
    Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM.
    Oncol Rep; 2005 Nov 01; 14(5):1357-63. PubMed ID: 16211309
    [Abstract] [Full Text] [Related]

  • 14. Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
    Mc Gee MM, Campiani G, Ramunno A, Fattorusso C, Nacci V, Lawler M, Williams DC, Zisterer DM.
    J Pharmacol Exp Ther; 2001 Jan 01; 296(1):31-40. PubMed ID: 11123359
    [Abstract] [Full Text] [Related]

  • 15. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells.
    Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM.
    Br J Cancer; 2011 Jan 18; 104(2):281-9. PubMed ID: 21179037
    [Abstract] [Full Text] [Related]

  • 16. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.
    Zisterer DM, Campiani G, Nacci V, Williams DC.
    J Pharmacol Exp Ther; 2000 Apr 18; 293(1):48-59. PubMed ID: 10734152
    [Abstract] [Full Text] [Related]

  • 17. Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.
    Bright SA, McElligott AM, O'Connell JW, O'Connor L, Carroll P, Campiani G, Deininger MW, Conneally E, Lawler M, Williams DC, Zisterer DM.
    Br J Cancer; 2010 May 11; 102(10):1474-82. PubMed ID: 20407438
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.
    Greene LM, Nolan DP, Regan-Komito D, Campiani G, Williams DC, Zisterer DM.
    Int J Oncol; 2013 Sep 11; 43(3):927-35. PubMed ID: 23799546
    [Abstract] [Full Text] [Related]

  • 19. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.
    Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M.
    Cancer Biol Ther; 2016 Aug 02; 17(8):849-58. PubMed ID: 26392056
    [Abstract] [Full Text] [Related]

  • 20. Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.
    Keshelava N, Davicioni E, Wan Z, Ji L, Sposto R, Triche TJ, Reynolds CP.
    J Natl Cancer Inst; 2007 Jul 18; 99(14):1107-19. PubMed ID: 17623797
    [Abstract] [Full Text] [Related]

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