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Journal Abstract Search

198 related items for PubMed ID: 24428639

  • 1. Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
    Lam T, Hilgers MT, Cunningham ML, Kwan BP, Nelson KJ, Brown-Driver V, Ong V, Trzoss M, Hough G, Shaw KJ, Finn J.
    J Med Chem; 2014 Feb 13; 57(3):651-68. PubMed ID: 24428639
    [Abstract] [Full Text] [Related]

  • 2. Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
    Li X, Hilgers M, Cunningham M, Chen Z, Trzoss M, Zhang J, Kohnen L, Lam T, Creighton C, G C K, Nelson K, Kwan B, Stidham M, Brown-Driver V, Shaw KJ, Finn J.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5171-6. PubMed ID: 21831637
    [Abstract] [Full Text] [Related]

  • 3. Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening.
    Wyss PC, Gerber P, Hartman PG, Hubschwerlen C, Locher H, Marty HP, Stahl M.
    J Med Chem; 2003 Jun 05; 46(12):2304-12. PubMed ID: 12773035
    [Abstract] [Full Text] [Related]

  • 4. Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
    Bastien D, Ebert MC, Forge D, Toulouse J, Kadnikova N, Perron F, Mayence A, Huang TL, Vanden Eynde JJ, Pelletier JN.
    J Med Chem; 2012 Apr 12; 55(7):3182-92. PubMed ID: 22424148
    [Abstract] [Full Text] [Related]

  • 5. Increased hydrophobic interactions of iclaprim with Staphylococcus aureus dihydrofolate reductase are responsible for the increase in affinity and antibacterial activity.
    Oefner C, Bandera M, Haldimann A, Laue H, Schulz H, Mukhija S, Parisi S, Weiss L, Lociuro S, Dale GE.
    J Antimicrob Chemother; 2009 Apr 12; 63(4):687-98. PubMed ID: 19211577
    [Abstract] [Full Text] [Related]

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  • 7. Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity.
    Hassan AS, Askar AA, Naglah AM, Almehizia AA, Ragab A.
    Molecules; 2020 Jun 02; 25(11):. PubMed ID: 32498469
    [Abstract] [Full Text] [Related]

  • 8. Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim.
    Heaslet H, Harris M, Fahnoe K, Sarver R, Putz H, Chang J, Subramanyam C, Barreiro G, Miller JR.
    Proteins; 2009 Aug 15; 76(3):706-17. PubMed ID: 19280600
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and antistaphylococcal activity of N-substituted-1H-benzimidazole-sulphonamides.
    Püsküllü MO, Yildiz S, Göker H.
    Arch Pharm (Weinheim); 2010 Jan 15; 343(1):31-9. PubMed ID: 19927309
    [Abstract] [Full Text] [Related]

  • 10. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
    Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W.
    J Med Chem; 1998 Aug 27; 41(18):3426-34. PubMed ID: 9719595
    [Abstract] [Full Text] [Related]

  • 11. Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates.
    Harer S, Bhatia M, Kawade V.
    Med Chem; 2019 Aug 27; 15(7):813-832. PubMed ID: 30727904
    [Abstract] [Full Text] [Related]

  • 12. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study.
    Alzahrani AY, Ammar YA, Abu-Elghait M, Salem MA, Assiri MA, Ali TE, Ragab A.
    Bioorg Chem; 2022 Feb 27; 119():105571. PubMed ID: 34959177
    [Abstract] [Full Text] [Related]

  • 13. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
    Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF.
    J Med Chem; 2004 Mar 11; 47(6):1475-86. PubMed ID: 14998335
    [Abstract] [Full Text] [Related]

  • 14. Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
    Kawatkar SP, Keating TA, Olivier NB, Breen JN, Green OM, Guler SY, Hentemann MF, Loch JT, McKenzie AR, Newman JV, Otterson LG, Martínez-Botella G.
    J Med Chem; 2014 Jun 12; 57(11):4584-97. PubMed ID: 24828090
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and antimicrobial activity of some novel 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives.
    Kus C, Sözüdönmez F, Altanlar N.
    Arch Pharm (Weinheim); 2009 Jan 12; 342(1):54-60. PubMed ID: 19051196
    [Abstract] [Full Text] [Related]

  • 16. Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).
    Sekiguchi J, Tharavichitkul P, Miyoshi-Akiyama T, Chupia V, Fujino T, Araake M, Irie A, Morita K, Kuratsuji T, Kirikae T.
    Antimicrob Agents Chemother; 2005 Sep 12; 49(9):3948-51. PubMed ID: 16127079
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines.
    Nammalwar B, Bourne CR, Bunce RA, Wakeham N, Bourne PC, Ramnarayan K, Mylvaganam S, Berlin KD, Barrow EW, Barrow WW.
    ChemMedChem; 2012 Nov 12; 7(11):1974-82. PubMed ID: 22930550
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, antibacterial activity and docking study of some new trimethoprim derivatives.
    Rashid U, Ahmad W, Hassan SF, Qureshi NA, Niaz B, Muhammad B, Imdad S, Sajid M.
    Bioorg Med Chem Lett; 2016 Dec 01; 26(23):5749-5753. PubMed ID: 28327306
    [Abstract] [Full Text] [Related]

  • 19. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
    Piper JR, Johnson CA, Krauth CA, Carter RL, Hosmer CA, Queener SF, Borotz SE, Pfefferkorn ER.
    J Med Chem; 1996 Mar 15; 39(6):1271-80. PubMed ID: 8632434
    [Abstract] [Full Text] [Related]

  • 20. Dihydrofolate reductase inhibitors as antibacterial agents.
    Hawser S, Lociuro S, Islam K.
    Biochem Pharmacol; 2006 Mar 30; 71(7):941-8. PubMed ID: 16359642
    [Abstract] [Full Text] [Related]

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