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Journal Abstract Search

436 related items for PubMed ID: 24449215

  • 1. Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.
    Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G.
    Blood; 2014 Mar 13; 123(11):1729-38. PubMed ID: 24449215
    [Abstract] [Full Text] [Related]

  • 2. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
    Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD.
    Blood; 2011 Dec 15; 118(25):6544-52. PubMed ID: 22012064
    [Abstract] [Full Text] [Related]

  • 3. MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.
    Prange KHM, Mandoli A, Kuznetsova T, Wang SY, Sotoca AM, Marneth AE, van der Reijden BA, Stunnenberg HG, Martens JHA.
    Oncogene; 2017 Jun 08; 36(23):3346-3356. PubMed ID: 28114278
    [Abstract] [Full Text] [Related]

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  • 5. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.
    Stubbs MC, Kim YM, Krivtsov AV, Wright RD, Feng Z, Agarwal J, Kung AL, Armstrong SA.
    Leukemia; 2008 Jan 08; 22(1):66-77. PubMed ID: 17851551
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  • 7. Relationships between AML1-ETO and MLL-AF9 fusion gene expressions and hematological parameters in acute myeloid leukemia.
    Muddathir ARM, Hamid TAM, Mohamed Elamin E, Khabour OF.
    Gulf J Oncolog; 2020 Sep 08; 1(34):65-69. PubMed ID: 33431365
    [Abstract] [Full Text] [Related]

  • 8. Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.
    Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, Mulloy JC.
    J Clin Invest; 2013 Sep 08; 123(9):3876-88. PubMed ID: 23979164
    [Abstract] [Full Text] [Related]

  • 9. RUNX1::ETO and CBFβ::MYH11 converge on aberrant activation of BCAT1 to confer a therapeutic vulnerability in core-binding factor-acute myeloid leukaemia.
    Wang S, Liu Y, Zhao X, Wang X, Lou J, Jin P, Zhang Y, Yu J, Wang K.
    Br J Haematol; 2024 Aug 08; 205(2):552-567. PubMed ID: 38802066
    [Abstract] [Full Text] [Related]

  • 10. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
    Cunningham L, Finckbeiner S, Hyde RK, Southall N, Marugan J, Yedavalli VR, Dehdashti SJ, Reinhold WC, Alemu L, Zhao L, Yeh JR, Sood R, Pommier Y, Austin CP, Jeang KT, Zheng W, Liu P.
    Proc Natl Acad Sci U S A; 2012 Sep 04; 109(36):14592-7. PubMed ID: 22912405
    [Abstract] [Full Text] [Related]

  • 11. RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development.
    Zhen T, Cao Y, Ren G, Zhao L, Hyde RK, Lopez G, Feng D, Alemu L, Zhao K, Liu PP.
    Blood; 2020 Nov 19; 136(21):2373-2385. PubMed ID: 32929473
    [Abstract] [Full Text] [Related]

  • 12. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling.
    Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH.
    Blood; 2012 Jul 26; 120(4):868-79. PubMed ID: 22613795
    [Abstract] [Full Text] [Related]

  • 13. Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.
    Gessner A, Thomas M, Castro PG, Büchler L, Scholz A, Brümmendorf TH, Soria NM, Vormoor J, Greil J, Heidenreich O.
    Leukemia; 2010 Oct 26; 24(10):1751-9. PubMed ID: 20686504
    [Abstract] [Full Text] [Related]

  • 14. Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.
    Chen Y, Ernst P.
    Cell Cycle; 2019 Jul 26; 18(14):1525-1531. PubMed ID: 31161857
    [Abstract] [Full Text] [Related]

  • 15. Learning from mouse models of MLL fusion gene-driven acute leukemia.
    Schwaller J.
    Biochim Biophys Acta Gene Regul Mech; 2020 Aug 26; 1863(8):194550. PubMed ID: 32320749
    [Abstract] [Full Text] [Related]

  • 16. Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells.
    Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F, Katayama N, Kitamura T, Nosaka T.
    Blood; 2013 Aug 15; 122(7):1271-83. PubMed ID: 23838347
    [Abstract] [Full Text] [Related]

  • 17. The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.
    Osaki H, Walf-Vorderwülbecke V, Mangolini M, Zhao L, Horton SJ, Morrone G, Schuringa JJ, de Boer J, Williams O.
    Leukemia; 2013 Jul 15; 27(7):1461-8. PubMed ID: 23403462
    [Abstract] [Full Text] [Related]

  • 18. AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia.
    Dunne J, Gascoyne DM, Lister TA, Brady HJ, Heidenreich O, Young BD.
    Cancer Res; 2010 May 15; 70(10):3985-95. PubMed ID: 20460523
    [Abstract] [Full Text] [Related]

  • 19. Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL‑AF9 translocation.
    Wang F, Li Z, Wang G, Tian X, Zhou J, Yu W, Fan Z, Dong L, Lu J, Xu J, Zhang W, Liang A.
    Mol Med Rep; 2020 Feb 15; 21(2):883-893. PubMed ID: 31789407
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