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Journal Abstract Search

134 related items for PubMed ID: 24588327

  • 1. Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis.
    Lobach AR, Uetrecht J.
    Chem Res Toxicol; 2014 Apr 21; 27(4):699-709. PubMed ID: 24588327
    [Abstract] [Full Text] [Related]

  • 2. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
    Maggs JL, Williams D, Pirmohamed M, Park BK.
    J Pharmacol Exp Ther; 1995 Dec 21; 275(3):1463-75. PubMed ID: 8531117
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  • 3. Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis.
    Lai WG, Gardner I, Zahid N, Uetrecht JP.
    Drug Metab Dispos; 2000 Mar 21; 28(3):255-63. PubMed ID: 10681368
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  • 4. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo.
    Gardner I, Popović M, Zahid N, Uetrecht JP.
    Chem Res Toxicol; 2005 Sep 21; 18(9):1384-94. PubMed ID: 16167830
    [Abstract] [Full Text] [Related]

  • 5. A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo.
    Gardner I, Leeder JS, Chin T, Zahid N, Uetrecht JP.
    Mol Pharmacol; 1998 Jun 21; 53(6):999-1008. PubMed ID: 9614201
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  • 6. Metabolism of vesnarinone by activated neutrophils: implications for vesnarinone-induced agranulocytosis.
    Uetrecht JP, Zahid N, Whitfield D.
    J Pharmacol Exp Ther; 1994 Sep 21; 270(3):865-72. PubMed ID: 7932198
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  • 7. Myeloperoxidase accumulates at the neutrophil surface and enhances cell metabolism and oxidant release during pregnancy.
    Kindzelskii AL, Clark AJ, Espinoza J, Maeda N, Aratani Y, Romero R, Petty HR.
    Eur J Immunol; 2006 Jun 21; 36(6):1619-28. PubMed ID: 16688678
    [Abstract] [Full Text] [Related]

  • 8. Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis.
    Iverson S, Zahid N, Uetrecht JP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):175-99. PubMed ID: 12399162
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  • 10. Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite.
    Rashid MH, Babu D, Tran N, Reiz B, Siraki AG.
    Chem Res Toxicol; 2022 Jun 20; 35(6):1001-1010. PubMed ID: 35575633
    [Abstract] [Full Text] [Related]

  • 11. Exploring an animal model of amodiaquine-induced liver injury in rats and mice.
    Liu F, Cai P, Metushi I, Li J, Nakayawa T, Vega L, Uetrecht J.
    J Immunotoxicol; 2016 Sep 20; 13(5):694-712. PubMed ID: 27416278
    [Abstract] [Full Text] [Related]

  • 12. The cytotoxicity of clozapine metabolites: implications for predicting clozapine-induced agranulocytosis.
    Tschen AC, Rieder MJ, Oyewumi LK, Freeman DJ.
    Clin Pharmacol Ther; 1999 May 20; 65(5):526-32. PubMed ID: 10340918
    [Abstract] [Full Text] [Related]

  • 13. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.
    Liu ZC, Uetrecht JP.
    J Pharmacol Exp Ther; 1995 Dec 20; 275(3):1476-83. PubMed ID: 8531118
    [Abstract] [Full Text] [Related]

  • 14. Myeloperoxidase as a generator of drug free radicals.
    Uetrecht JP.
    Biochem Soc Symp; 1995 Dec 20; 61():163-70. PubMed ID: 8660393
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  • 16. Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis.
    Ng W, Kennar R, Uetrecht J.
    Chem Res Toxicol; 2014 Jul 21; 27(7):1104-8. PubMed ID: 24968069
    [Abstract] [Full Text] [Related]

  • 17. Potential role of a quetiapine metabolite in quetiapine-induced neutropenia and agranulocytosis.
    Li X, Cameron MD.
    Chem Res Toxicol; 2012 May 21; 25(5):1004-11. PubMed ID: 22506851
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