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Journal Abstract Search

118 related items for PubMed ID: 24608634

  • 1. Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.
    Ballard TE, Orozco CC, Obach RS.
    Drug Metab Dispos; 2014 May; 42(5):899-902. PubMed ID: 24608634
    [Abstract] [Full Text] [Related]

  • 2. Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
    Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS.
    Drug Metab Dispos; 2010 Oct; 38(10):1900-5. PubMed ID: 20595376
    [Abstract] [Full Text] [Related]

  • 3. Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.
    Hutzler JM, Ring BJ, Anderson SR.
    Drug Metab Dispos; 2015 Dec; 43(12):1917-28. PubMed ID: 26363026
    [Abstract] [Full Text] [Related]

  • 4. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
    Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA.
    Chem Res Toxicol; 2009 Feb; 22(2):357-68. PubMed ID: 19146377
    [Abstract] [Full Text] [Related]

  • 5. Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds.
    Hultman Ia, Vedin C, Abrahamsson A, Winiwarter S, Darnell M.
    Mol Pharm; 2016 Aug 01; 13(8):2796-807. PubMed ID: 27377099
    [Abstract] [Full Text] [Related]

  • 6. Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.
    Ballard TE, Wang S, Cox LM, Moen MA, Krzyzewski S, Ukairo O, Obach RS.
    Drug Metab Dispos; 2016 Feb 01; 44(2):172-9. PubMed ID: 26608083
    [Abstract] [Full Text] [Related]

  • 7. Further Assessment of the Relay Hepatocyte Assay for Determination of Intrinsic Clearance of Slowly Metabolised Compounds Using Radioactivity Monitoring and LC-MS Methods.
    Murgasova R.
    Eur J Drug Metab Pharmacokinet; 2019 Dec 01; 44(6):817-826. PubMed ID: 31422548
    [Abstract] [Full Text] [Related]

  • 8. Analysis of polar metabolites by hydrophilic interaction chromatography--MS/MS.
    Jian W, Xu Y, Edom RW, Weng N.
    Bioanalysis; 2011 Apr 01; 3(8):899-912. PubMed ID: 21510763
    [Abstract] [Full Text] [Related]

  • 9. A novel relay method for determining low-clearance values.
    Di L, Trapa P, Obach RS, Atkinson K, Bi YA, Wolford AC, Tan B, McDonald TS, Lai Y, Tremaine LM.
    Drug Metab Dispos; 2012 Sep 01; 40(9):1860-5. PubMed ID: 22645091
    [Abstract] [Full Text] [Related]

  • 10. In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
    Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB.
    J Pharmacol Exp Ther; 2012 Oct 01; 343(1):134-44. PubMed ID: 22776955
    [Abstract] [Full Text] [Related]

  • 11. A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.
    Lahoz A, Donato MT, Montero S, Castell JV, Gómez-Lechón MJ.
    Rapid Commun Mass Spectrom; 2008 Oct 01; 22(2):240-4. PubMed ID: 18088071
    [Abstract] [Full Text] [Related]

  • 12. A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening.
    Prot JM, Videau O, Brochot C, Legallais C, Bénech H, Leclerc E.
    Int J Pharm; 2011 Apr 15; 408(1-2):67-75. PubMed ID: 21295126
    [Abstract] [Full Text] [Related]

  • 13. Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism.
    Liu Y, Wei J, Lu J, Lei D, Yan S, Li X.
    Mater Sci Eng C Mater Biol Appl; 2016 Jun 15; 63():475-84. PubMed ID: 27040241
    [Abstract] [Full Text] [Related]

  • 14. Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
    Kostrubsky SE, Strom SC, Ellis E, Nelson SD, Mutlib AE.
    Chem Res Toxicol; 2007 Oct 15; 20(10):1503-12. PubMed ID: 17900172
    [Abstract] [Full Text] [Related]

  • 15. Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.
    Kamimura H, Nakada N, Suzuki K, Mera A, Souda K, Murakami Y, Tanaka K, Iwatsubo T, Kawamura A, Usui T.
    Drug Metab Pharmacokinet; 2010 Oct 15; 25(3):223-35. PubMed ID: 20610881
    [Abstract] [Full Text] [Related]

  • 16. In vitro evaluation of metabolic drug-drug interactions: a descriptive and critical commentary.
    Li AP.
    Curr Protoc Toxicol; 2007 Oct 15; Chapter 4():Unit 4.25. PubMed ID: 23045147
    [Abstract] [Full Text] [Related]

  • 17. A practical strategy for characterization of the metabolic profile of chiral drugs using combinatory liquid chromatography-mass spectrometric techniques: application to tetrahydropalmatine enantiomers and their metabolites in rat urine.
    Zhang Y, Dong X, Le J, Wen J, Lin Z, Liu Y, Lou Z, Chai Y, Hong Z.
    J Pharm Biomed Anal; 2014 Jun 15; 94():152-62. PubMed ID: 24598170
    [Abstract] [Full Text] [Related]

  • 18. Characterization of the in vitro metabolic profile of amlodipine in rat using liquid chromatography-mass spectrometry.
    Suchanova B, Kostiainen R, Ketola RA.
    Eur J Pharm Sci; 2008 Jan 15; 33(1):91-9. PubMed ID: 18055188
    [Abstract] [Full Text] [Related]

  • 19. In Vitro Metabolism of Slowly Cleared G Protein-Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism.
    Kamel A, Bowlin S, Hosea N, Arkilo D, Laurenza A.
    Drug Metab Dispos; 2021 Feb 15; 49(2):121-132. PubMed ID: 33273044
    [Abstract] [Full Text] [Related]

  • 20. Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model.
    Burton RD, Hieronymus T, Chamem T, Heim D, Anderson S, Zhu X, Hutzler JM.
    Drug Metab Dispos; 2018 Nov 15; 46(11):1617-1625. PubMed ID: 30135244
    [Abstract] [Full Text] [Related]

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