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Journal Abstract Search

173 related items for PubMed ID: 24636945

  • 1. Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.
    Graham TH, Shu M, Verras A, Chen Q, Garcia-Calvo M, Li X, Lisnock J, Tong X, Tung EC, Wiltsie J, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2014 Apr 01; 24(7):1657-60. PubMed ID: 24636945
    [Abstract] [Full Text] [Related]

  • 2. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
    Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Li X, Lisnock J, Shen Z, Tong X, Tung EC, Wiltsie J, Xu S, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2013 Dec 01; 23(23):6228-33. PubMed ID: 24157366
    [Abstract] [Full Text] [Related]

  • 3. Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
    Wu Z, Yang C, Xiong Y, Feng Z, Lombardo M, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen Q, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1774-8. PubMed ID: 22248857
    [Abstract] [Full Text] [Related]

  • 4. Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
    Shen HC, Ding FX, Zhou C, Xiong Y, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen D, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1299-305. PubMed ID: 21315588
    [Abstract] [Full Text] [Related]

  • 5. Non-oxime pyrazole based inhibitors of B-Raf kinase.
    Newhouse BJ, Hansen JD, Grina J, Welch M, Topalov G, Littman N, Callejo M, Martinson M, Galbraith S, Laird ER, Brandhuber BJ, Vigers G, Morales T, Woessner R, Randolph N, Lyssikatos J, Olivero A.
    Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3488-92. PubMed ID: 21536432
    [Abstract] [Full Text] [Related]

  • 6. Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
    Wu Z, Yang C, Graham TH, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Shen Z, Chen Q, Bleasby K, Sinharoy R, Hale JJ, Tata JR, Pinto S, Colletti SL, Shen DM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1727-30. PubMed ID: 22290078
    [Abstract] [Full Text] [Related]

  • 7. Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.
    Ren L, Laird ER, Buckmelter AJ, Dinkel V, Gloor SL, Grina J, Newhouse B, Rasor K, Hastings G, Gradl SN, Rudolph J.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1165-8. PubMed ID: 22196124
    [Abstract] [Full Text] [Related]

  • 8. Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.
    Graham TH.
    Expert Opin Ther Pat; 2017 Oct 15; 27(10):1077-1088. PubMed ID: 28699813
    [Abstract] [Full Text] [Related]

  • 9. Pyrazinoindolone inhibitors of MAPKAP-K2.
    Goldberg DR, Choi Y, Cogan D, Corson M, DeLeon R, Gao A, Gruenbaum L, Hao MH, Joseph D, Kashem MA, Miller C, Moss N, Netherton MR, Pargellis CP, Pelletier J, Sellati R, Skow D, Torcellini C, Tseng YC, Wang J, Wasti R, Werneburg B, Wu JP, Xiong Z.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):938-41. PubMed ID: 18221871
    [Abstract] [Full Text] [Related]

  • 10. Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
    Shen HC, Ding FX, Jiang J, Verras A, Chabin RM, Xu S, Tong X, Chen Q, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Murphy BA, Gorski JN, Wiltsie J, SinhaRoy R, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1550-6. PubMed ID: 22264488
    [Abstract] [Full Text] [Related]

  • 11. A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
    Graham TH, Liu W, Verras A, Sebhat IK, Xiong Y, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xiao J, Xie D, Xu S, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2811-7. PubMed ID: 22444683
    [Abstract] [Full Text] [Related]

  • 12. A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
    Graham TH, Liu W, Verras A, Reibarkh M, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xie D, Xu S, Xiao J, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2818-22. PubMed ID: 22444685
    [Abstract] [Full Text] [Related]

  • 13. PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
    Dounay AB, Anderson M, Bechle BM, Evrard E, Gan X, Kim JY, McAllister LA, Pandit J, Rong S, Salafia MA, Tuttle JB, Zawadzke LE, Verhoest PR.
    Bioorg Med Chem Lett; 2013 Apr 01; 23(7):1961-6. PubMed ID: 23466229
    [Abstract] [Full Text] [Related]

  • 14. [Study on derivatives of 5-amino-4-acylamino-1H-pyrazole as inhibitors of furin].
    Kibirev VK, Osadchuk TV, Vadziuk OB, Shablykin OV, Kozachenko AP, Chumachenko SA, Popil'nichenko SV, Brovarets VS.
    Ukr Biokhim Zh (1999); 2011 Apr 01; 83(1):30-7. PubMed ID: 21800646
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.
    Fioravanti R, Desideri N, Biava M, Proietti Monaco L, Grammatica L, Yáñez M.
    Bioorg Med Chem Lett; 2013 Sep 15; 23(18):5128-30. PubMed ID: 23927971
    [Abstract] [Full Text] [Related]

  • 16. Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.
    Bindi S, Fancelli D, Alli C, Berta D, Bertrand JA, Cameron AD, Cappella P, Carpinelli P, Cervi G, Croci V, D'Anello M, Forte B, Giorgini ML, Marsiglio A, Moll J, Pesenti E, Pittalà V, Pulici M, Riccardi-Sirtori F, Roletto F, Soncini C, Storici P, Varasi M, Volpi D, Zugnoni P, Vianello P.
    Bioorg Med Chem; 2010 Oct 01; 18(19):7113-20. PubMed ID: 20817473
    [Abstract] [Full Text] [Related]

  • 17. Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.
    Chen HJ, Liu Y, Wang LN, Shen Q, Li J, Nan FJ.
    Bioorg Med Chem Lett; 2010 May 01; 20(9):2876-9. PubMed ID: 20363629
    [Abstract] [Full Text] [Related]

  • 18. Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).
    Huynh T, Chen Z, Pang S, Geng J, Bandiera T, Bindi S, Vianello P, Roletto F, Thieffine S, Galvani A, Vaccaro W, Poss MA, Trainor GL, Lorenzi MV, Gottardis M, Jayaraman L, Purandare AV.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):2924-7. PubMed ID: 19419866
    [Abstract] [Full Text] [Related]

  • 19. The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review.
    Dwivedi J, Sharma S, Jain S, Singh A.
    Mini Rev Med Chem; 2018 Jun 01; 18(11):918-947. PubMed ID: 28971774
    [Abstract] [Full Text] [Related]

  • 20. Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
    Zhou C, Garcia-Calvo M, Pinto S, Lombardo M, Feng Z, Bender K, Pryor KD, Bhatt UR, Chabin RM, Geissler WM, Shen Z, Tong X, Zhang Z, Wong KK, Roy RS, Chapman KT, Yang L, Xiong Y.
    J Med Chem; 2010 Oct 14; 53(19):7251-63. PubMed ID: 20857914
    [Abstract] [Full Text] [Related]

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