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231 related items for PubMed ID: 24657936

  • 1. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.
    Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Caraglia M, Tassone P, Tagliaferri P.
    Cancer Biol Ther; 2014 Jun 01; 15(6):797-805. PubMed ID: 24657936
    [Abstract] [Full Text] [Related]

  • 2. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
    Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissié J, Malavaud B, Waxman J, Cuvillier O.
    Cancer Res; 2010 Nov 01; 70(21):8651-61. PubMed ID: 20959468
    [Abstract] [Full Text] [Related]

  • 3. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
    Nagaoka Y, Otsuki K, Fujita T, Uesato S.
    Biol Pharm Bull; 2008 Jun 01; 31(6):1177-81. PubMed ID: 18520051
    [Abstract] [Full Text] [Related]

  • 4. Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.
    Yoshino T, Tabunoki H, Sugiyama S, Ishii K, Kim SU, Satoh J.
    Cell Mol Neurobiol; 2011 Oct 01; 31(7):1009-20. PubMed ID: 21519925
    [Abstract] [Full Text] [Related]

  • 5. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
    Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V.
    J Biol Chem; 2009 Feb 27; 284(9):5467-77. PubMed ID: 19119142
    [Abstract] [Full Text] [Related]

  • 6. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
    Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ.
    Cell Signal; 2010 Oct 27; 22(10):1536-42. PubMed ID: 20570726
    [Abstract] [Full Text] [Related]

  • 7. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma.
    Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS.
    Hepatology; 2011 Jun 27; 53(6):1943-58. PubMed ID: 21391227
    [Abstract] [Full Text] [Related]

  • 8. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway.
    Li MH, Hla T, Ferrer F.
    Pediatr Blood Cancer; 2013 Sep 27; 60(9):1418-23. PubMed ID: 23704073
    [Abstract] [Full Text] [Related]

  • 9. FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.
    Zhang N, Qi Y, Wadham C, Wang L, Warren A, Di W, Xia P.
    Autophagy; 2010 Nov 27; 6(8):1157-67. PubMed ID: 20935520
    [Abstract] [Full Text] [Related]

  • 10. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
    Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marfè G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R.
    Clin Cancer Res; 2013 Jan 01; 19(1):138-47. PubMed ID: 23166225
    [Abstract] [Full Text] [Related]

  • 11. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies.
    Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, Arlinghaus RB, Quintas-Cardama A, Goldman JM, Apperley J, Reid A, Milojkovic D, Ziolo MT, Marcucci G, Ogretmen B, Neviani P, Perrotti D.
    Blood; 2013 Sep 12; 122(11):1923-34. PubMed ID: 23926298
    [Abstract] [Full Text] [Related]

  • 12. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice.
    Zheng T, Meng X, Wang J, Chen X, Yin D, Liang Y, Song X, Pan S, Jiang H, Liu L.
    J Cell Biochem; 2010 Sep 01; 111(1):218-28. PubMed ID: 20506484
    [Abstract] [Full Text] [Related]

  • 13. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling.
    Lu Z, Wang J, Zheng T, Liang Y, Yin D, Song R, Pei T, Pan S, Jiang H, Liu L.
    BMC Cancer; 2014 Oct 25; 14():783. PubMed ID: 25344679
    [Abstract] [Full Text] [Related]

  • 14. Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
    Paugh SW, Cassidy MP, He H, Milstien S, Sim-Selley LJ, Spiegel S, Selley DE.
    Mol Pharmacol; 2006 Jul 25; 70(1):41-50. PubMed ID: 16571654
    [Abstract] [Full Text] [Related]

  • 15. Molecular targets of FTY720 (fingolimod).
    Pitman MR, Woodcock JM, Lopez AF, Pitson SM.
    Curr Mol Med; 2012 Dec 25; 12(10):1207-19. PubMed ID: 22834825
    [Abstract] [Full Text] [Related]

  • 16. Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.
    Potteck H, Nieuwenhuis B, Lüth A, van der Giet M, Kleuser B.
    Cell Physiol Biochem; 2010 Dec 25; 26(1):67-78. PubMed ID: 20502006
    [Abstract] [Full Text] [Related]

  • 17. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
    Lim KG, Sun C, Bittman R, Pyne NJ, Pyne S.
    Cell Signal; 2011 Oct 25; 23(10):1590-5. PubMed ID: 21620961
    [Abstract] [Full Text] [Related]

  • 18. Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.
    Long JS, Fujiwara Y, Edwards J, Tannahill CL, Tigyi G, Pyne S, Pyne NJ.
    J Biol Chem; 2010 Nov 12; 285(46):35957-66. PubMed ID: 20837468
    [Abstract] [Full Text] [Related]

  • 19. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
    Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S.
    FEBS Lett; 2003 Nov 06; 554(1-2):189-93. PubMed ID: 14596938
    [Abstract] [Full Text] [Related]

  • 20. Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.
    Li W, Li J, Wang Y, Zhang K, Li N, Tian Z, Ni B, Wang H, Ruan Z.
    Oncotarget; 2016 Dec 06; 7(49):80586-80598. PubMed ID: 27811359
    [Abstract] [Full Text] [Related]

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