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160 related items for PubMed ID: 24721830

  • 21. Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.
    Worek F, Aurbek N, Thiermann H.
    J Appl Toxicol; 2007; 27(6):582-8. PubMed ID: 17370251
    [Abstract] [Full Text] [Related]

  • 22. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase.
    Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radić Z, Kovalevsky A.
    J Biol Chem; 2019 Jul 05; 294(27):10607-10618. PubMed ID: 31138650
    [Abstract] [Full Text] [Related]

  • 23. Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates.
    Worek F, Reiter G, Eyer P, Szinicz L.
    Arch Toxicol; 2002 Sep 05; 76(9):523-9. PubMed ID: 12242610
    [Abstract] [Full Text] [Related]

  • 24. Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.
    Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radić Z.
    Arch Toxicol; 2016 Mar 05; 90(3):603-16. PubMed ID: 25743373
    [Abstract] [Full Text] [Related]

  • 25. Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.
    Esposito EX, Stouch TR, Wymore T, Madura JD.
    Chem Res Toxicol; 2014 Jan 21; 27(1):99-110. PubMed ID: 24443939
    [Abstract] [Full Text] [Related]

  • 26. Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.
    Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P.
    Chem Biol Interact; 2013 Mar 25; 203(1):67-71. PubMed ID: 22975155
    [Abstract] [Full Text] [Related]

  • 27. The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study.
    Cuya T, Gonçalves ADS, da Silva JAV, Ramalho TC, Kuca K, C C França T.
    J Biomol Struct Dyn; 2018 Oct 25; 36(13):3444-3452. PubMed ID: 29019446
    [Abstract] [Full Text] [Related]

  • 28. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents.
    Cadieux CL, Wang H, Zhang Y, Koenig JA, Shih TM, McDonough J, Koh J, Cerasoli D.
    Chem Biol Interact; 2016 Nov 25; 259(Pt B):133-141. PubMed ID: 27062893
    [Abstract] [Full Text] [Related]

  • 29. Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.
    Scheffel C, Thiermann H, Worek F.
    Toxicol Lett; 2015 Feb 03; 232(3):557-65. PubMed ID: 25522658
    [Abstract] [Full Text] [Related]

  • 30. Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.
    Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z.
    Chem Biol Interact; 2019 Jul 01; 307():16-20. PubMed ID: 31004594
    [Abstract] [Full Text] [Related]

  • 31. Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose.
    Shih TM, Skovira JW, O'Donnell JC, McDonough JH.
    Toxicol Mech Methods; 2009 Sep 01; 19(6-7):386-400. PubMed ID: 19778239
    [Abstract] [Full Text] [Related]

  • 32. Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
    Shiloff JD, Clement JG.
    Toxicol Appl Pharmacol; 1987 Jun 30; 89(2):278-80. PubMed ID: 3299873
    [Abstract] [Full Text] [Related]

  • 33. Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates.
    Bi H, Ouyang Q, Wei Z, Zheng Z.
    Bioorg Chem; 2020 Jul 30; 100():103902. PubMed ID: 32388435
    [Abstract] [Full Text] [Related]

  • 34. Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro.
    Becker G, Kawan A, Gutzeit D, Worek F, Szinicz L.
    Arch Toxicol; 2007 Jun 30; 81(6):415-20. PubMed ID: 17151865
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  • 35. Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity.
    Amitai G, Gez R, Raveh L, Bar-Ner N, Grauer E, Chapman S.
    Chem Biol Interact; 2016 Nov 25; 259(Pt B):187-204. PubMed ID: 27129421
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  • 36. Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.
    Worek F, Herkert NM, Koller M, Aurbek N, Thiermann H.
    Toxicol Lett; 2009 Jun 01; 187(2):119-23. PubMed ID: 19429253
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  • 37. In vivo protection studies of bis-quaternary 2-(hydroxyimino)- N-(pyridin-3-yl) acetamide derivatives against sarin poisoning in mice.
    Swami D, Karade HN, Acharya J, Kumar P.
    Hum Exp Toxicol; 2017 Jan 01; 36(1):23-32. PubMed ID: 26962110
    [Abstract] [Full Text] [Related]

  • 38. Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
    Worek F, von der Wellen J, Musilek K, Kuca K, Thiermann H.
    Arch Toxicol; 2012 Sep 01; 86(9):1379-86. PubMed ID: 22437842
    [Abstract] [Full Text] [Related]

  • 39. New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.
    Wei Z, Liu YQ, Zhou XB, Luo Y, Huang CQ, Wang YA, Zheng ZB, Li S.
    Bioorg Med Chem Lett; 2014 Dec 15; 24(24):5743-5748. PubMed ID: 25453812
    [Abstract] [Full Text] [Related]

  • 40. Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.
    Bester SM, Guelta MA, Cheung J, Winemiller MD, Bae SY, Myslinski J, Pegan SD, Height JJ.
    Chem Res Toxicol; 2018 Dec 17; 31(12):1405-1417. PubMed ID: 30462502
    [Abstract] [Full Text] [Related]

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