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163 related items for PubMed ID: 24755487

  • 1. A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death.
    Shing JC, Choi JW, Chapman R, Schroeder MA, Sarkaria JN, Fauq A, Bram RJ.
    Cancer Biol Ther; 2014 Jul; 15(7):895-905. PubMed ID: 24755487
    [Abstract] [Full Text] [Related]

  • 2. 2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase.
    Chang WL, Chang CS, Chiang PC, Ho YF, Liu JF, Chang KW, Guh JH.
    Br J Pharmacol; 2010 Aug; 160(7):1677-89. PubMed ID: 20649571
    [Abstract] [Full Text] [Related]

  • 3. 6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells.
    Chung KS, Choi HE, Shin JS, Cho YW, Choi JH, Cho WJ, Lee KT.
    Carcinogenesis; 2013 Aug; 34(8):1852-60. PubMed ID: 23615402
    [Abstract] [Full Text] [Related]

  • 4. CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells.
    Dinić J, Ríos-Luci C, Karpaviciene I, Cikotiene I, Fernandes MX, Pešić M, Padrón JM.
    Invest New Drugs; 2020 Jun; 38(3):584-598. PubMed ID: 31177401
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  • 5. A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer.
    Ahn S, Hwang DJ, Barrett CM, Yang J, Duke CB, Miller DD, Dalton JT.
    Cancer Chemother Pharmacol; 2011 Feb; 67(2):293-304. PubMed ID: 20383708
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  • 8. Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.
    Xu W, Xi B, Wu J, An H, Zhu J, Abassi Y, Feinstein SC, Gaylord M, Geng B, Yan H, Fan W, Sui M, Wang X, Xu X.
    Mol Cancer Ther; 2009 Dec; 8(12):3318-30. PubMed ID: 19996274
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  • 9. Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.
    Ling YH, Jiang JD, Holland JF, Perez-Soler R.
    Mol Pharmacol; 2002 Sep; 62(3):529-38. PubMed ID: 12181429
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  • 10. 5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells.
    Bai Z, Liu X, Guan Q, Ding N, Wei Q, Tong B, Zhao M, Zhang W, Ma L.
    Chem Biol Interact; 2020 Jan 05; 315():108886. PubMed ID: 31682804
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  • 11. 2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines.
    Boichuk S, Galembikova A, Bikinieva F, Dunaev P, Aukhadieva A, Syuzov K, Zykova S, Igidov N, Ksenofontov A, Bocharov P.
    Molecules; 2021 Jan 25; 26(3):. PubMed ID: 33503939
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  • 14. NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine - site.
    Das Mukherjee D, Kumar NM, Tantak MP, Datta S, Ghosh Dastidar D, Kumar D, Chakrabarti G.
    Biochim Biophys Acta Mol Cell Res; 2020 Oct 25; 1867(10):118762. PubMed ID: 32502617
    [Abstract] [Full Text] [Related]

  • 15. A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
    Chiang NJ, Lin CI, Liou JP, Kuo CC, Chang CY, Chen LT, Chang JY.
    PLoS One; 2013 Oct 25; 8(3):e58953. PubMed ID: 23554962
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  • 16. Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanism.
    Waraky A, Akopyan K, Parrow V, Strömberg T, Axelson M, Abrahmsén L, Lindqvist A, Larsson O, Aleem E.
    Oncotarget; 2014 Sep 30; 5(18):8379-92. PubMed ID: 25268741
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  • 17. PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization.
    Wu X, Shen Y.
    Biochem Biophys Res Commun; 2018 May 23; 499(4):927-933. PubMed ID: 29626471
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  • 18. BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
    Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY.
    Cancer Res; 2004 Jul 01; 64(13):4621-8. PubMed ID: 15231674
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  • 19. Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib.
    Tsai AC, Wang CY, Liou JP, Pai HC, Hsiao CJ, Chang JY, Wang JC, Teng CM, Pan SL.
    Cell Death Dis; 2014 Apr 10; 5(4):e1162. PubMed ID: 24722287
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  • 20. R-253 disrupts microtubule networks in multiple tumor cell lines.
    Gururaja TL, Goff D, Kinoshita T, Goldstein E, Yung S, McLaughlin J, Pali E, Huang J, Singh R, Daniel-Issakani S, Hitoshi Y, Cooper RD, Payan DG.
    Clin Cancer Res; 2006 Jun 15; 12(12):3831-42. PubMed ID: 16778111
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