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Journal Abstract Search

197 related items for PubMed ID: 24758147

  • 1. Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
    Kang S, Tang W, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB.
    J Med Chem; 2014 May 22; 57(10):4382-96. PubMed ID: 24758147
    [Abstract] [Full Text] [Related]

  • 2. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
    Hah JM, Martásek P, Roman LJ, Silverman RB.
    J Med Chem; 2003 Apr 24; 46(9):1661-9. PubMed ID: 12699384
    [Abstract] [Full Text] [Related]

  • 3. Structural basis for isoform-selective inhibition in nitric oxide synthase.
    Poulos TL, Li H.
    Acc Chem Res; 2013 Feb 19; 46(2):390-8. PubMed ID: 23030042
    [Abstract] [Full Text] [Related]

  • 4. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
    Jing Q, Li H, Chreifi G, Roman LJ, Martásek P, Poulos TL, Silverman RB.
    Bioorg Med Chem Lett; 2013 Oct 15; 23(20):5674-9. PubMed ID: 23993333
    [Abstract] [Full Text] [Related]

  • 5. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
    Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB.
    J Med Chem; 2015 Nov 12; 58(21):8694-712. PubMed ID: 26469213
    [Abstract] [Full Text] [Related]

  • 6. Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.
    Jing Q, Li H, Roman LJ, Martásek P, Poulos TL, Silverman RB.
    Bioorg Med Chem Lett; 2014 Sep 15; 24(18):4504-4510. PubMed ID: 25149509
    [Abstract] [Full Text] [Related]

  • 7. Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms.
    Oliveira BL, Moreira IS, Fernandes PA, Ramos MJ, Santos I, Correia JD.
    J Mol Model; 2013 Apr 15; 19(4):1537-51. PubMed ID: 23263357
    [Abstract] [Full Text] [Related]

  • 8. Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
    Flinspach M, Li H, Jamal J, Yang W, Huang H, Silverman RB, Poulos TL.
    Biochemistry; 2004 May 11; 43(18):5181-7. PubMed ID: 15122883
    [Abstract] [Full Text] [Related]

  • 9. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
    Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL.
    Nat Struct Mol Biol; 2004 Jan 11; 11(1):54-9. PubMed ID: 14718923
    [Abstract] [Full Text] [Related]

  • 10. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
    Hah JM, Roman LJ, Martásek P, Silverman RB.
    J Med Chem; 2001 Aug 02; 44(16):2667-70. PubMed ID: 11472219
    [Abstract] [Full Text] [Related]

  • 11. Discovery of a series of aminopiperidines as novel iNOS inhibitors.
    Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):336-43. PubMed ID: 18024030
    [Abstract] [Full Text] [Related]

  • 12. Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase.
    Li H, Hardy CD, Reidl CT, Jing Q, Xue F, Cinelli M, Silverman RB, Poulos TL.
    Biochemistry; 2024 Mar 19; 63(6):788-796. PubMed ID: 38417024
    [Abstract] [Full Text] [Related]

  • 13.
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  • 14. Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
    Ji H, Gómez-Vidal JA, Martasek P, Roman LJ, Silverman RB.
    J Med Chem; 2006 Oct 19; 49(21):6254-63. PubMed ID: 17034131
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.
    Ichimori K, Stuehr DJ, Atkinson RN, King SB.
    J Med Chem; 1999 May 20; 42(10):1842-8. PubMed ID: 10346937
    [Abstract] [Full Text] [Related]

  • 16. Novel inhibitors of neuronal nitric oxide synthase.
    Di Giacomo C, Sorrenti V, Salerno L, Cardile V, Guerrera F, Siracusa MA, Avitabile M, Vanella A.
    Exp Biol Med (Maywood); 2003 May 20; 228(5):486-90. PubMed ID: 12709574
    [Abstract] [Full Text] [Related]

  • 17. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
    Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL.
    Biochemistry; 2010 Dec 28; 49(51):10803-10. PubMed ID: 21138269
    [Abstract] [Full Text] [Related]

  • 18. Fire ant venom alkaloid, isosolenopsin A, a potent and selective inhibitor of neuronal nitric oxide synthase.
    Yi GB, McClendon D, Desaiah D, Goddard J, Lister A, Moffitt J, Meer RK, deShazo R, Lee KS, Rockhold RW.
    Int J Toxicol; 2003 Dec 28; 22(2):81-6. PubMed ID: 12745988
    [Abstract] [Full Text] [Related]

  • 19. Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
    Matter H, Kumar HS, Fedorov R, Frey A, Kotsonis P, Hartmann E, Fröhlich LG, Reif A, Pfleiderer W, Scheurer P, Ghosh DK, Schlichting I, Schmidt HH.
    J Med Chem; 2005 Jul 28; 48(15):4783-92. PubMed ID: 16033258
    [Abstract] [Full Text] [Related]

  • 20. Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo.
    Dunbar AY, Jenkins GJ, Jianmongkol S, Nakatsuka M, Lowe ER, Lau M, Osawa Y.
    Drug Metab Dispos; 2006 Sep 28; 34(9):1448-56. PubMed ID: 16738031
    [Abstract] [Full Text] [Related]

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