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232 related items for PubMed ID: 24841075

  • 1. Daurinol, a catalytic inhibitor of topoisomerase IIα, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase.
    Kang K, Nho CW, Kim ND, Song DG, Park YG, Kim M, Pan CH, Shin D, Oh SH, Oh HS.
    Int J Oncol; 2014 Aug; 45(2):558-66. PubMed ID: 24841075
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of topoisomerase IIalpha expression by transforming growth factor-beta1 is abrogated by the papillomavirus E7 protein.
    Satterwhite DJ, White RL, Matsunami N, Neufeld KL.
    Cancer Res; 2000 Dec 15; 60(24):6989-94. PubMed ID: 11156401
    [Abstract] [Full Text] [Related]

  • 3. A novel topoisomerase inhibitor, daurinol, suppresses growth of HCT116 cells with low hematological toxicity compared to etoposide.
    Kang K, Oh SH, Yun JH, Jho EH, Kang JH, Batsuren D, Tunsag J, Park KH, Kim M, Nho CW.
    Neoplasia; 2011 Nov 15; 13(11):1043-57. PubMed ID: 22131880
    [Abstract] [Full Text] [Related]

  • 4. N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase.
    Baviskar AT, Madaan C, Preet R, Mohapatra P, Jain V, Agarwal A, Guchhait SK, Kundu CN, Banerjee UC, Bharatam PV.
    J Med Chem; 2011 Jul 28; 54(14):5013-30. PubMed ID: 21644529
    [Abstract] [Full Text] [Related]

  • 5. 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.
    Park SE, Chang IH, Jun KY, Lee E, Lee ES, Na Y, Kwon Y.
    Eur J Med Chem; 2013 Nov 28; 69():139-45. PubMed ID: 24013413
    [Abstract] [Full Text] [Related]

  • 6. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles.
    Shen Y, Chen W, Zhao B, Hao H, Li Z, Lu C, Shen Y.
    Biochem Biophys Res Commun; 2014 Oct 24; 453(3):302-8. PubMed ID: 25242524
    [Abstract] [Full Text] [Related]

  • 7. (S)-Erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells.
    Hikita K, Yamakage Y, Okunaga H, Motoyama Y, Matsuyama H, Matsuoka K, Murata T, Nakayoshi T, Oda A, Kato K, Tanaka H, Asao N, Dan S, Kaneda N.
    Bioorg Med Chem; 2021 Jan 15; 30():115904. PubMed ID: 33341500
    [Abstract] [Full Text] [Related]

  • 8. Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity.
    Naowaratwattana W, De-Eknamkul W, De Mejia EG.
    J Med Food; 2010 Oct 15; 13(5):1045-56. PubMed ID: 20828312
    [Abstract] [Full Text] [Related]

  • 9. Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells.
    Islam MS, Park S, Song C, Kadi AA, Kwon Y, Rahman AF.
    Eur J Med Chem; 2017 Jan 05; 125():49-67. PubMed ID: 27654394
    [Abstract] [Full Text] [Related]

  • 10. Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
    Sehested M, Wessel I, Jensen LH, Holm B, Oliveri RS, Kenwrick S, Creighton AM, Nitiss JL, Jensen PB.
    Cancer Res; 1998 Apr 01; 58(7):1460-8. PubMed ID: 9537249
    [Abstract] [Full Text] [Related]

  • 11. Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells.
    Sudan S, Rupasinghe HP.
    Anticancer Res; 2014 Apr 01; 34(4):1691-9. PubMed ID: 24692698
    [Abstract] [Full Text] [Related]

  • 12. Selection of human leukemic CEM cells for resistance to the DNA topoisomerase II catalytic inhibitor ICRF-187 results in increased levels of topoisomerase IIalpha and altered G(2)/M checkpoint and apoptotic responses.
    Morgan SE, Cadena RS, Raimondi SC, Beck WT.
    Mol Pharmacol; 2000 Feb 01; 57(2):296-307. PubMed ID: 10648639
    [Abstract] [Full Text] [Related]

  • 13. Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors.
    Park S, Kadayat TM, Jun KY, Thapa Magar TB, Bist G, Shrestha A, Lee ES, Kwon Y.
    Eur J Med Chem; 2017 Jan 05; 125():14-28. PubMed ID: 27643560
    [Abstract] [Full Text] [Related]

  • 14. HU-331 is a catalytic inhibitor of topoisomerase IIα.
    Regal KM, Mercer SL, Deweese JE.
    Chem Res Toxicol; 2014 Dec 15; 27(12):2044-51. PubMed ID: 25409338
    [Abstract] [Full Text] [Related]

  • 15. 3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells.
    Gong Y, Firestone GL, Bjeldanes LF.
    Mol Pharmacol; 2006 Apr 15; 69(4):1320-7. PubMed ID: 16385077
    [Abstract] [Full Text] [Related]

  • 16. DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
    Menendez JA, Vellon L, Lupu R.
    Int J Mol Med; 2006 Dec 15; 18(6):1081-7. PubMed ID: 17089011
    [Abstract] [Full Text] [Related]

  • 17. Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex.
    Hofland K, Petersen BO, Falck J, Helin K, Jensen PB, Sehested M.
    Clin Cancer Res; 2000 Apr 15; 6(4):1488-97. PubMed ID: 10778981
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor.
    Ahmad P, Woo H, Jun KY, Kadi AA, Abdel-Aziz HA, Kwon Y, Rahman AF.
    Bioorg Med Chem; 2016 Apr 15; 24(8):1898-908. PubMed ID: 26988802
    [Abstract] [Full Text] [Related]

  • 19. A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells.
    Patra N, De U, Kang JA, Kim JM, Ahn MY, Lee J, Jung JH, Chung HY, Moon HR, Kim HS.
    Eur J Pharmacol; 2011 May 11; 658(2-3):98-107. PubMed ID: 21376033
    [Abstract] [Full Text] [Related]

  • 20. Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain.
    Qin Y, Meng L, Hu C, Duan W, Zuo Z, Lin L, Zhang X, Ding J.
    Mol Cancer Ther; 2007 Sep 11; 6(9):2429-40. PubMed ID: 17876042
    [Abstract] [Full Text] [Related]

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