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Journal Abstract Search

412 related items for PubMed ID: 24889603

  • 1. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
    Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, Xie T, Marto JA, Chen Z, Gray NS, Westover KD.
    Proc Natl Acad Sci U S A; 2014 Jun 17; 111(24):8895-900. PubMed ID: 24889603
    [Abstract] [Full Text] [Related]

  • 2. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.
    Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, Gray NS.
    Angew Chem Int Ed Engl; 2014 Jan 03; 53(1):199-204. PubMed ID: 24259466
    [Abstract] [Full Text] [Related]

  • 3. Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules.
    Goody RS, Müller MP, Rauh D.
    Cell Chem Biol; 2019 Oct 17; 26(10):1338-1348. PubMed ID: 31378709
    [Abstract] [Full Text] [Related]

  • 4. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
    Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM.
    Nature; 2013 Nov 28; 503(7477):548-51. PubMed ID: 24256730
    [Abstract] [Full Text] [Related]

  • 5. 1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH.
    Pálfy G, Vida I, Perczel A.
    Biomol NMR Assign; 2020 Apr 28; 14(1):1-7. PubMed ID: 31468366
    [Abstract] [Full Text] [Related]

  • 6. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
    Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM.
    Cell Chem Biol; 2017 Dec 21; 24(12):1455-1466.e14. PubMed ID: 29033317
    [Abstract] [Full Text] [Related]

  • 7. Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model.
    Zhang B, Zhang Y, Shacter E, Zheng Y.
    Biochemistry; 2005 Feb 22; 44(7):2566-76. PubMed ID: 15709769
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  • 10. G proteins, effectors and GAPs: structure and mechanism.
    Sprang SR.
    Curr Opin Struct Biol; 1997 Dec 22; 7(6):849-56. PubMed ID: 9434906
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  • 11. The structural basis for the transition from Ras-GTP to Ras-GDP.
    Hall BE, Bar-Sagi D, Nassar N.
    Proc Natl Acad Sci U S A; 2002 Sep 17; 99(19):12138-42. PubMed ID: 12213964
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  • 12. Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap.
    Nicely NI, Kosak J, de Serrano V, Mattos C.
    Structure; 2004 Nov 17; 12(11):2025-36. PubMed ID: 15530367
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  • 13. Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
    Ihara K, Muraguchi S, Kato M, Shimizu T, Shirakawa M, Kuroda S, Kaibuchi K, Hakoshima T.
    J Biol Chem; 1998 Apr 17; 273(16):9656-66. PubMed ID: 9545299
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  • 18. Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
    Xiong Y, Lu J, Hunter J, Li L, Scott D, Choi HG, Lim SM, Manandhar A, Gondi S, Sim T, Westover KD, Gray NS.
    ACS Med Chem Lett; 2017 Jan 12; 8(1):61-66. PubMed ID: 28105276
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  • 19. DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site.
    Kearney BM, Johnson CW, Roberts DM, Swartz P, Mattos C.
    J Mol Biol; 2014 Feb 06; 426(3):611-29. PubMed ID: 24189050
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  • 20. Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.
    Maegley KA, Admiraal SJ, Herschlag D.
    Proc Natl Acad Sci U S A; 1996 Aug 06; 93(16):8160-6. PubMed ID: 8710841
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