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Journal Abstract Search

338 related items for PubMed ID: 24895457

  • 1. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.
    Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM.
    Circulation; 2014 Jul 15; 130(3):224-34. PubMed ID: 24895457
    [Abstract] [Full Text] [Related]

  • 2. Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs.
    Kim JG, Sung DJ, Kim HJ, Park SW, Won KJ, Kim B, Shin HC, Kim KS, Leem CH, Zhang YH, Cho H, Bae YM.
    PLoS One; 2016 Jul 15; 11(3):e0149198. PubMed ID: 26930604
    [Abstract] [Full Text] [Related]

  • 3. Azithromycin Causes a Novel Proarrhythmic Syndrome.
    Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT.
    Circ Arrhythm Electrophysiol; 2017 Apr 15; 10(4):. PubMed ID: 28408648
    [Abstract] [Full Text] [Related]

  • 4. Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.
    Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA.
    Br J Pharmacol; 2012 Jan 15; 165(2):467-78. PubMed ID: 21718297
    [Abstract] [Full Text] [Related]

  • 5. Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.
    Qiu XS, Chauveau S, Anyukhovsky EP, Rahim T, Jiang YP, Harleton E, Feinmark SJ, Lin RZ, Coronel R, Janse MJ, Opthof T, Rosen TS, Cohen IS, Rosen MR.
    Circ Arrhythm Electrophysiol; 2016 Apr 15; 9(4):e003655. PubMed ID: 27071826
    [Abstract] [Full Text] [Related]

  • 6. Is there a need to add another dimension (time) to the evaluation of the arrhythmogenic potential of new drug candidates in vitro?
    Townsend C.
    Circulation; 2014 Jul 15; 130(3):219-20. PubMed ID: 24895458
    [No Abstract] [Full Text] [Related]

  • 7. Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
    Davie C, Pierre-Valentin J, Pollard C, Standen N, Mitcheson J, Alexander P, Thong B.
    J Cardiovasc Electrophysiol; 2004 Nov 15; 15(11):1302-9. PubMed ID: 15574182
    [Abstract] [Full Text] [Related]

  • 8. Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
    Orvos P, Kohajda Z, Szlovák J, Gazdag P, Árpádffy-Lovas T, Tóth D, Geramipour A, Tálosi L, Jost N, Varró A, Virág L.
    Toxicol Sci; 2019 Apr 01; 168(2):365-380. PubMed ID: 30561737
    [Abstract] [Full Text] [Related]

  • 9. Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes.
    Song Y, Shryock JC, Wu L, Belardinelli L.
    J Cardiovasc Pharmacol; 2004 Aug 01; 44(2):192-9. PubMed ID: 15243300
    [Abstract] [Full Text] [Related]

  • 10. Multiple mechanisms underlie increased cardiac late sodium current.
    Kroncke BM, Yang T, Roden DM.
    Heart Rhythm; 2019 Jul 01; 16(7):1091-1097. PubMed ID: 30677491
    [Abstract] [Full Text] [Related]

  • 11. Common Ancestry-Specific Ion Channel Variants Predispose to Drug-Induced Arrhythmias.
    Wada Y, Yang T, Shaffer CM, Daniel LL, Glazer AM, Davogustto GE, Lowery BD, Farber-Eger EH, Wells QS, Roden DM.
    Circulation; 2022 Jan 25; 145(4):299-308. PubMed ID: 34994586
    [Abstract] [Full Text] [Related]

  • 12. RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
    Orth PM, Hesketh JC, Mak CK, Yang Y, Lin S, Beatch GN, Ezrin AM, Fedida D.
    Cardiovasc Res; 2006 Jun 01; 70(3):486-96. PubMed ID: 16545351
    [Abstract] [Full Text] [Related]

  • 13. LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
    Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG.
    Br J Pharmacol; 2019 Oct 01; 176(19):3871-3885. PubMed ID: 31339551
    [Abstract] [Full Text] [Related]

  • 14. A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
    Boulay E, Abernathy MM, Chui R, Friedrichs GS, Gendron-Parra N, Greiter-Wilke A, Guillon JM, Koerner JE, Menard A, Steidl-Nichols J, Pierson J, Pugsley MK, Rossman EI, Strauss D, Troncy E, Valentin JP, Wisialowski T, Authier S.
    Int J Toxicol; 2019 Oct 01; 38(1):23-32. PubMed ID: 30567462
    [Abstract] [Full Text] [Related]

  • 15. An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel.
    Crumb WJ, Vicente J, Johannesen L, Strauss DG.
    J Pharmacol Toxicol Methods; 2016 Oct 01; 81():251-62. PubMed ID: 27060526
    [Abstract] [Full Text] [Related]

  • 16. Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
    Antoons G, Oros A, Beekman JD, Engelen MA, Houtman MJ, Belardinelli L, Stengl M, Vos MA.
    J Am Coll Cardiol; 2010 Feb 23; 55(8):801-9. PubMed ID: 20170820
    [Abstract] [Full Text] [Related]

  • 17. New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts.
    Kui P, Orosz S, Takács H, Sarusi A, Csík N, Rárosi F, Csekő C, Varró A, Papp JG, Forster T, Farkas AS, Farkas A.
    J Pharmacol Toxicol Methods; 2016 Feb 23; 80():26-34. PubMed ID: 27063345
    [Abstract] [Full Text] [Related]

  • 18. Electrophysiological mechanisms of vandetanib-induced cardiotoxicity: Comparison of action potentials in rabbit Purkinje fibers and pluripotent stem cell-derived cardiomyocytes.
    Lee HA, Hyun SA, Byun B, Chae JH, Kim KS.
    PLoS One; 2018 Feb 23; 13(4):e0195577. PubMed ID: 29630634
    [Abstract] [Full Text] [Related]

  • 19. Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.
    Guérard NC, Traebert M, Suter W, Dumotier BM.
    J Pharmacol Toxicol Methods; 2008 Feb 23; 58(1):32-40. PubMed ID: 18582585
    [Abstract] [Full Text] [Related]

  • 20. Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes.
    Guo D, Liu Q, Liu T, Elliott G, Gingras M, Kowey PR, Yan GX.
    J Cardiovasc Pharmacol; 2011 Jan 23; 57(1):79-85. PubMed ID: 20980921
    [Abstract] [Full Text] [Related]

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