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762 related items for PubMed ID: 24928920

  • 1. Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis.
    van der Kraan PM.
    Biomed Mater Eng; 2014; 24(1 Suppl):75-80. PubMed ID: 24928920
    [Abstract] [Full Text] [Related]

  • 2. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
    Blaney Davidson EN, Remst DF, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM.
    J Immunol; 2009 Jun 15; 182(12):7937-45. PubMed ID: 19494318
    [Abstract] [Full Text] [Related]

  • 3. TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?
    Blaney Davidson EN, van Caam AP, Vitters EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent PL, van de Loo FA, van der Kraan PM.
    Osteoarthritis Cartilage; 2015 Mar 15; 23(3):478-86. PubMed ID: 25529198
    [Abstract] [Full Text] [Related]

  • 4. ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.
    Finnson KW, Parker WL, ten Dijke P, Thorikay M, Philip A.
    J Bone Miner Res; 2008 Jun 15; 23(6):896-906. PubMed ID: 18333754
    [Abstract] [Full Text] [Related]

  • 5. Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage.
    Madej W, van Caam A, Davidson EN, Hannink G, Buma P, van der Kraan PM.
    Osteoarthritis Cartilage; 2016 Jan 15; 24(1):146-57. PubMed ID: 26247611
    [Abstract] [Full Text] [Related]

  • 6. Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and β-catenin activation.
    Charlier E, Malaise O, Zeddou M, Neuville S, Cobraiville G, Deroyer C, Sanchez C, Gillet P, Kurth W, de Seny D, Relic B, Malaise MG.
    Osteoarthritis Cartilage; 2016 Feb 15; 24(2):315-24. PubMed ID: 26318657
    [Abstract] [Full Text] [Related]

  • 7. Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling.
    Madej W, van Caam A, Blaney Davidson EN, van der Kraan PM, Buma P.
    Osteoarthritis Cartilage; 2014 Jul 15; 22(7):1018-25. PubMed ID: 24795273
    [Abstract] [Full Text] [Related]

  • 8. Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.
    Wang Q, Tan QY, Xu W, Qi HB, Chen D, Zhou S, Ni ZH, Kuang L, Guo JY, Huang JL, Wang XX, Wang ZQ, Su N, Chen L, Chen B, Jiang WL, Gao Y, Chen HG, Du XL, Xie YL, Chen L.
    Osteoarthritis Cartilage; 2017 Nov 15; 25(11):1868-1879. PubMed ID: 28716756
    [Abstract] [Full Text] [Related]

  • 9. Age-dependent alteration of TGF-β signalling in osteoarthritis.
    van der Kraan PM, Goumans MJ, Blaney Davidson E, ten Dijke P.
    Cell Tissue Res; 2012 Jan 15; 347(1):257-65. PubMed ID: 21638205
    [Abstract] [Full Text] [Related]

  • 10. A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis.
    van der Kraan PM, Blaney Davidson EN, van den Berg WB.
    Arthritis Res Ther; 2010 Jan 15; 12(1):201. PubMed ID: 20156325
    [Abstract] [Full Text] [Related]

  • 11. Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity.
    Blaney Davidson EN, Scharstuhl A, Vitters EL, van der Kraan PM, van den Berg WB.
    Arthritis Res Ther; 2005 Jan 15; 7(6):R1338-47. PubMed ID: 16277687
    [Abstract] [Full Text] [Related]

  • 12. Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8.
    van den Bosch MH, Blom AB, van Lent PL, van Beuningen HM, Blaney Davidson EN, van der Kraan PM, van den Berg WB.
    Cell Signal; 2014 May 15; 26(5):951-8. PubMed ID: 24463008
    [Abstract] [Full Text] [Related]

  • 13. Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.
    Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ.
    J Bone Miner Res; 2006 Jan 15; 21(1):4-16. PubMed ID: 16355269
    [Abstract] [Full Text] [Related]

  • 14. Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling.
    Wang PE, Zhang L, Ying J, Jin X, Luo C, Xu S, Dong R, Xiao L, Tong P, Jin H.
    J Transl Med; 2018 Mar 20; 16(1):72. PubMed ID: 29554973
    [Abstract] [Full Text] [Related]

  • 15. Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA.
    Xu L, Golshirazian I, Asbury BJ, Li Y.
    Histol Histopathol; 2014 May 20; 29(5):609-18. PubMed ID: 24135912
    [Abstract] [Full Text] [Related]

  • 16. Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes.
    Thielen NGM, van Caam APM, V Beuningen HM, Vitters EL, van den Bosch MHJ, Koenders MI, van de Loo FAJ, Blaney Davidson EN, van der Kraan PM.
    Osteoarthritis Cartilage; 2023 Nov 20; 31(11):1481-1490. PubMed ID: 37652257
    [Abstract] [Full Text] [Related]

  • 17. TGF-ß induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling.
    Remst DF, Blaney Davidson EN, Vitters EL, Bank RA, van den Berg WB, van der Kraan PM.
    Cell Tissue Res; 2014 Jan 20; 355(1):163-71. PubMed ID: 24192939
    [Abstract] [Full Text] [Related]

  • 18. Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites.
    Tardif G, Reboul P, Dupuis M, Geng C, Duval N, Pelletier JP, Martel-Pelletier J.
    J Rheumatol; 2001 Jul 20; 28(7):1631-9. PubMed ID: 11469472
    [Abstract] [Full Text] [Related]

  • 19. Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes.
    Finnson KW, Parker WL, Chi Y, Hoemann CD, Goldring MB, Antoniou J, Philip A.
    Osteoarthritis Cartilage; 2010 Nov 20; 18(11):1518-27. PubMed ID: 20833252
    [Abstract] [Full Text] [Related]

  • 20. CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes.
    Deroyer C, Charlier E, Neuville S, Malaise O, Gillet P, Kurth W, Chariot A, Malaise M, de Seny D.
    Cell Death Dis; 2019 Feb 04; 10(2):103. PubMed ID: 30718510
    [Abstract] [Full Text] [Related]

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