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143 related items for PubMed ID: 2493687

  • 1. Modulation of phenytoin teratogenicity and embryonic covalent binding by acetylsalicylic acid, caffeic acid, and alpha-phenyl-N-t-butylnitrone: implications for bioactivation by prostaglandin synthetase.
    Wells PG, Zubovits JT, Wong ST, Molinari LM, Ali S.
    Toxicol Appl Pharmacol; 1989 Feb; 97(2):192-202. PubMed ID: 2493687
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
    Wells PG, Nagai MK, Greco GS.
    Toxicol Appl Pharmacol; 1989 Mar 01; 97(3):406-14. PubMed ID: 2609340
    [Abstract] [Full Text] [Related]

  • 3. Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.
    Yu WK, Wells PG.
    Toxicol Appl Pharmacol; 1995 Mar 01; 131(1):1-12. PubMed ID: 7878664
    [Abstract] [Full Text] [Related]

  • 4. In vivo phenytoin-initiated oxidative damage to proteins and lipids in murine maternal hepatic and embryonic tissue organelles: potential molecular targets of chemical teratogenesis.
    Liu L, Wells PG.
    Toxicol Appl Pharmacol; 1994 Apr 01; 125(2):247-55. PubMed ID: 8171432
    [Abstract] [Full Text] [Related]

  • 5. In vitro bioactivation of phenytoin to a reactive free radical intermediate by prostaglandin synthetase, horseradish peroxidase, and thyroid peroxidase.
    Kubow S, Wells PG.
    Mol Pharmacol; 1989 Apr 01; 35(4):504-11. PubMed ID: 2539558
    [Abstract] [Full Text] [Related]

  • 6. Enhancement of murine phenytoin teratogenicity by the gamma-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine and by the glutathione depletor diethyl maleate.
    Wong M, Helston LM, Wells PG.
    Teratology; 1989 Aug 01; 40(2):127-41. PubMed ID: 2772848
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of phenytoin bioactivation and teratogenicity by dietary n-3 fatty acids in mice.
    Kubow S.
    Lipids; 1992 Sep 01; 27(9):721-8. PubMed ID: 1487972
    [Abstract] [Full Text] [Related]

  • 8. Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice.
    Wells PG, Vo HP.
    Toxicol Appl Pharmacol; 1989 Mar 01; 97(3):398-405. PubMed ID: 2609339
    [Abstract] [Full Text] [Related]

  • 9. Pharmacological studies on the potentiation of phenytoin teratogenicity by acetaminophen.
    Lum JT, Wells PG.
    Teratology; 1986 Feb 01; 33(1):53-72. PubMed ID: 3738810
    [Abstract] [Full Text] [Related]

  • 10. Oxidative damage in chemical teratogenesis.
    Wells PG, Kim PM, Laposa RR, Nicol CJ, Parman T, Winn LM.
    Mutat Res; 1997 Dec 12; 396(1-2):65-78. PubMed ID: 9434860
    [Abstract] [Full Text] [Related]

  • 11. DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues.
    Liu L, Wells PG.
    Free Radic Biol Med; 1995 Nov 12; 19(5):639-48. PubMed ID: 8529923
    [Abstract] [Full Text] [Related]

  • 12. Effects of N-acetylcysteine on fetal development and on phenytoin teratogenicity in mice.
    Wong M, Wells PG.
    Teratog Carcinog Mutagen; 1988 Nov 12; 8(2):65-79. PubMed ID: 2899918
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate.
    Arlen RR, Wells PG.
    J Pharmacol Exp Ther; 1996 Jun 12; 277(3):1649-58. PubMed ID: 8667234
    [Abstract] [Full Text] [Related]

  • 14. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.
    Parman T, Wiley MJ, Wells PG.
    Nat Med; 1999 May 12; 5(5):582-5. PubMed ID: 10229238
    [Abstract] [Full Text] [Related]

  • 15. Phenytoin embryotoxicity: role of enzymatic bioactivation in a murine embryo culture model.
    Shanks MJ, Wiley MJ, Kubow S, Wells PG.
    Teratology; 1989 Oct 12; 40(4):311-20. PubMed ID: 2814893
    [Abstract] [Full Text] [Related]

  • 16. Modulation of embryonic glutathione reductase and phenytoin teratogenicity by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
    Wong M, Wells PG.
    J Pharmacol Exp Ther; 1989 Jul 12; 250(1):336-42. PubMed ID: 2746506
    [Abstract] [Full Text] [Related]

  • 17. Phenytoin covalent binding and embryopathy in mouse embryos co-cultured with maternal hepatocytes from mouse, rat, and rabbit.
    Ozolins TR, Wiley MJ, Wells PG.
    Biochem Pharmacol; 1995 Nov 27; 50(11):1831-40. PubMed ID: 8615862
    [Abstract] [Full Text] [Related]

  • 18. Maternal administration of superoxide dismutase and catalase in phenytoin teratogenicity.
    Winn LM, Wells PG.
    Free Radic Biol Med; 1999 Feb 27; 26(3-4):266-74. PubMed ID: 9895216
    [Abstract] [Full Text] [Related]

  • 19. Evidence for embryonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis.
    Winn LM, Wells PG.
    Free Radic Biol Med; 1997 Feb 27; 22(4):607-21. PubMed ID: 9013124
    [Abstract] [Full Text] [Related]

  • 20. Evidence for embryonic peroxidase-catalyzed bioactivation and glutathione-dependent cytoprotection in phenytoin teratogenicity: modulation by eicosatetraynoic acid and buthionine sulfoximine in murine embryo culture.
    Miranda AF, Wiley MJ, Wells PG.
    Toxicol Appl Pharmacol; 1994 Feb 27; 124(2):230-41. PubMed ID: 8122268
    [Abstract] [Full Text] [Related]

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