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Journal Abstract Search

195 related items for PubMed ID: 24947510

  • 1.
    ; . PubMed ID:
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  • 2. Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
    Sunami A, Glaaser IW, Fozzard HA.
    Mol Pharmacol; 2001 Apr; 59(4):684-91. PubMed ID: 11259611
    [Abstract] [Full Text] [Related]

  • 3. A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.
    Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.
    J Biol Chem; 2010 Dec 10; 285(50):39458-70. PubMed ID: 20926383
    [Abstract] [Full Text] [Related]

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  • 5. Quaternary ammonium block of mutant Na+ channels lacking inactivation: features of a transition-intermediate mechanism.
    Kimbrough JT, Gingrich KJ.
    J Physiol; 2000 Nov 15; 529 Pt 1(Pt 1):93-106. PubMed ID: 11080254
    [Abstract] [Full Text] [Related]

  • 6. Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.
    Yarov-Yarovoy V, Brown J, Sharp EM, Clare JJ, Scheuer T, Catterall WA.
    J Biol Chem; 2001 Jan 05; 276(1):20-7. PubMed ID: 11024055
    [Abstract] [Full Text] [Related]

  • 7. A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.
    Zhou W, Chung I, Liu Z, Goldin AL, Dong K.
    Neuron; 2004 Apr 08; 42(1):101-12. PubMed ID: 15066268
    [Abstract] [Full Text] [Related]

  • 8. Mechanism of local anesthetic drug action on voltage-gated sodium channels.
    Fozzard HA, Lee PJ, Lipkind GM.
    Curr Pharm Des; 2005 Apr 08; 11(21):2671-86. PubMed ID: 16101448
    [Abstract] [Full Text] [Related]

  • 9. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
    Sunami A, Glaaser IW, Fozzard HA.
    Proc Natl Acad Sci U S A; 2000 Feb 29; 97(5):2326-31. PubMed ID: 10681444
    [Abstract] [Full Text] [Related]

  • 10. The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel.
    Yang YC, Hsieh JY, Kuo CC.
    J Gen Physiol; 2009 Aug 29; 134(2):95-113. PubMed ID: 19635852
    [Abstract] [Full Text] [Related]

  • 11. External pore residue mediates slow inactivation in mu 1 rat skeletal muscle sodium channels.
    Balser JR, Nuss HB, Chiamvimonvat N, Pérez-García MT, Marban E, Tomaselli GF.
    J Physiol; 1996 Jul 15; 494 ( Pt 2)(Pt 2):431-42. PubMed ID: 8842002
    [Abstract] [Full Text] [Related]

  • 12. A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor.
    Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH.
    Mol Pharmacol; 2005 Feb 15; 67(2):424-34. PubMed ID: 15659774
    [Abstract] [Full Text] [Related]

  • 13. Influence of pore residues on permeation properties in the Kv2.1 potassium channel. Evidence for a selective functional interaction of K+ with the outer vestibule.
    Consiglio JF, Andalib P, Korn SJ.
    J Gen Physiol; 2003 Feb 15; 121(2):111-24. PubMed ID: 12566539
    [Abstract] [Full Text] [Related]

  • 14. Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
    Ragsdale DS, McPhee JC, Scheuer T, Catterall WA.
    Science; 1994 Sep 16; 265(5179):1724-8. PubMed ID: 8085162
    [Abstract] [Full Text] [Related]

  • 15. Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
    McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM.
    J Physiol; 2007 Jun 01; 581(Pt 2):741-55. PubMed ID: 17363383
    [Abstract] [Full Text] [Related]

  • 16. Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics.
    Arcisio-Miranda M, Muroi Y, Chowdhury S, Chanda B.
    J Gen Physiol; 2010 Nov 01; 136(5):541-54. PubMed ID: 20937693
    [Abstract] [Full Text] [Related]

  • 17. Sodium channel selectivity filter regulates antiarrhythmic drug binding.
    Sunami A, Dudley SC, Fozzard HA.
    Proc Natl Acad Sci U S A; 1997 Dec 09; 94(25):14126-31. PubMed ID: 9391164
    [Abstract] [Full Text] [Related]

  • 18. On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving.
    Sun YM, Favre I, Schild L, Moczydlowski E.
    J Gen Physiol; 1997 Dec 09; 110(6):693-715. PubMed ID: 9382897
    [Abstract] [Full Text] [Related]

  • 19. Structural basis of ion permeation gating in Slo2.1 K+ channels.
    Garg P, Gardner A, Garg V, Sanguinetti MC.
    J Gen Physiol; 2013 Nov 09; 142(5):523-42. PubMed ID: 24166878
    [Abstract] [Full Text] [Related]

  • 20. Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.
    Yamagishi T, Xiong W, Kondratiev A, Vélez P, Méndez-Fitzwilliam A, Balser JR, Marbán E, Tomaselli GF.
    Mol Pharmacol; 2009 Oct 09; 76(4):861-71. PubMed ID: 19620257
    [Abstract] [Full Text] [Related]

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