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279 related items for PubMed ID: 24947996

  • 1. Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.
    Okada M, Shibuya K, Sato A, Seino S, Suzuki S, Seino M, Kitanaka C.
    Oncotarget; 2014 Jul 15; 5(13):5100-12. PubMed ID: 24947996
    [Abstract] [Full Text] [Related]

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  • 3. JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells.
    Recio-Boiles A, Ilmer M, Rhea PR, Kettlun C, Heinemann ML, Ruetering J, Vykoukal J, Alt E.
    Oncotarget; 2016 Mar 01; 7(9):9890-906. PubMed ID: 26840266
    [Abstract] [Full Text] [Related]

  • 4. JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.
    Liu Y, Zhang X, Wang J, Yang J, Tan WF.
    Acta Pharmacol Sin; 2015 Sep 01; 36(9):1099-106. PubMed ID: 26235742
    [Abstract] [Full Text] [Related]

  • 5. Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells.
    Okada M, Shibuya K, Sato A, Seino S, Watanabe E, Suzuki S, Seino M, Kitanaka C.
    Oncol Rep; 2013 Oct 01; 30(4):1957-64. PubMed ID: 23912840
    [Abstract] [Full Text] [Related]

  • 6. Latexin inhibits the proliferation of CD133+ miapaca-2 pancreatic cancer stem-like cells.
    Xue ZX, Zheng JH, Zheng ZQ, Cai JL, Ye XH, Wang C, Sun WJ, Zhou X, Lu MD, Li PH, Cai ZZ.
    World J Surg Oncol; 2014 Dec 30; 12():404. PubMed ID: 25551472
    [Abstract] [Full Text] [Related]

  • 7. Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
    Xiao Z, Li L, Li Y, Zhou W, Cheng J, Liu F, Zheng P, Zhang Y, Che Y.
    Cell Death Dis; 2014 May 22; 5(5):e1241. PubMed ID: 24853419
    [Abstract] [Full Text] [Related]

  • 8. Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.
    Moon BS, Jeong WJ, Park J, Kim TI, Min do S, Choi KY.
    J Natl Cancer Inst; 2014 Feb 22; 106(2):djt373. PubMed ID: 24491301
    [Abstract] [Full Text] [Related]

  • 9. K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.
    Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, Schmelzle T, Lai A, Brachmann SM, Bentires-Alj M, Roberts TM, Sellers WR, Hofmann F, Maira SM.
    PLoS One; 2012 Feb 22; 7(8):e44146. PubMed ID: 22952903
    [Abstract] [Full Text] [Related]

  • 10. Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway.
    Xu W, Wang Z, Zhang W, Qian K, Li H, Kong D, Li Y, Tang Y.
    Cancer Lett; 2015 Jan 28; 356(2 Pt B):613-27. PubMed ID: 25305448
    [Abstract] [Full Text] [Related]

  • 11. An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
    Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA.
    Nat Cell Biol; 2014 May 28; 16(5):457-68. PubMed ID: 24747441
    [Abstract] [Full Text] [Related]

  • 12. Requirement of JNK signaling for self-renewal and tumor-initiating capacity of ovarian cancer stem cells.
    Seino M, Okada M, Shibuya K, Seino S, Suzuki S, Ohta T, Kurachi H, Kitanaka C.
    Anticancer Res; 2014 Sep 28; 34(9):4723-31. PubMed ID: 25202050
    [Abstract] [Full Text] [Related]

  • 13. Inhibitory effects of transcription factor Ikaros on the expression of liver cancer stem cell marker CD133 in hepatocellular carcinoma.
    Zhang L, Li H, Ge C, Li M, Zhao FY, Hou HL, Zhu MX, Tian H, Zhang LX, Chen TY, Jiang GP, Xie HY, Cui Y, Yao M, Li JJ.
    Oncotarget; 2014 Nov 15; 5(21):10621-35. PubMed ID: 25301737
    [Abstract] [Full Text] [Related]

  • 14. Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis.
    Suzuki S, Okada M, Sanomachi T, Togashi K, Seino S, Sato A, Yamamoto M, Kitanaka C.
    J Biol Chem; 2020 Dec 25; 295(52):18328-18342. PubMed ID: 33115754
    [Abstract] [Full Text] [Related]

  • 15. Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties.
    Leung EL, Fiscus RR, Tung JW, Tin VP, Cheng LC, Sihoe AD, Fink LM, Ma Y, Wong MP.
    PLoS One; 2010 Nov 19; 5(11):e14062. PubMed ID: 21124918
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of the cancer stem cells-like properties by arsenic trioxide, involved in the attenuation of endogenous transforming growth factor beta signal.
    Li Y, Jiang F, Liu Q, Shen J, Wang X, Li Z, Zhang J, Lu X.
    Toxicol Sci; 2015 Jan 19; 143(1):156-64. PubMed ID: 25304214
    [Abstract] [Full Text] [Related]

  • 17. Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells.
    Leng Z, Tao K, Xia Q, Tan J, Yue Z, Chen J, Xi H, Li J, Zheng H.
    PLoS One; 2013 Jan 19; 8(2):e56082. PubMed ID: 23418515
    [Abstract] [Full Text] [Related]

  • 18. Effective suppression of the Kirsten rat sarcoma viral oncogene in pancreatic tumor cells via targeted small interfering RNA delivery using nanoparticles.
    Zeng L, Li J, Li J, Zhang Q, Qian C, Wu W, Lin Z, Liang J, Chen Y, Huang K.
    Pancreas; 2015 Mar 19; 44(2):250-9. PubMed ID: 25401377
    [Abstract] [Full Text] [Related]

  • 19. Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations.
    Yang Z, Zhang L, Ma A, Liu L, Li J, Gu J, Liu Y.
    PLoS One; 2011 Mar 19; 6(12):e28405. PubMed ID: 22145042
    [Abstract] [Full Text] [Related]

  • 20. Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.
    Wang JY, Chang CC, Chiang CC, Chen WM, Hung SC.
    J Cell Biochem; 2012 May 19; 113(5):1733-43. PubMed ID: 22213051
    [Abstract] [Full Text] [Related]

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