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Journal Abstract Search

166 related items for PubMed ID: 2498518

  • 1.
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  • 2. Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.
    DeGraw JI, Colwell WT, Brown VH, Sato M, Kisliuk RL, Gaumont Y, Thorndike J, Sirotnak FM.
    J Med Chem; 1988 Jan; 31(1):150-3. PubMed ID: 3121855
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  • 6. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
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  • 7. Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
    Rosowsky A, Forsch RA, Reich VE, Freisheim JH, Moran RG.
    J Med Chem; 1992 May 01; 35(9):1578-88. PubMed ID: 1578484
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  • 8. Novel nonclassical inhibitors of glycinamide ribonucleotide formyltransferase: 10-formyl and 10-hydroxymethyl derivatives of 5,8,10-trideazapteroic acid.
    Liu L, Nair MG, Kisliuk RL.
    J Mol Recognit; 1996 May 01; 9(2):169-74. PubMed ID: 8877810
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  • 9. Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
    Kelley JL, McLean EW, Cohn NK, Edelstein MP, Duch DS, Smith GK, Hanlon MH, Ferone R.
    J Med Chem; 1990 Feb 01; 33(2):561-7. PubMed ID: 2299624
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  • 11. Synthesis of aza homologues of folic acid.
    Martinelli JE, Chaykovsky M, Kisliuk RL, Gaumont Y.
    J Med Chem; 1979 Jul 01; 22(7):874-7. PubMed ID: 109617
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  • 13. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ.
    Bioorg Med Chem Lett; 2000 Jul 03; 10(13):1471-5. PubMed ID: 10888335
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  • 14. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2002 Aug 03; 10(8):2739-49. PubMed ID: 12057663
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  • 15. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4487-501. PubMed ID: 13129585
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  • 16. Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
    Caperelli CA, Conigliaro J.
    J Med Chem; 1986 Oct 01; 29(10):2117-9. PubMed ID: 3761327
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  • 17. A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors.
    Habeck LL, Leitner TA, Shackelford KA, Gossett LS, Schultz RM, Andis SL, Shih C, Grindey GB, Mendelsohn LG.
    Cancer Res; 1994 Feb 15; 54(4):1021-6. PubMed ID: 8313357
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  • 18. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
    Piper JR, McCaleb GS, Montgomery JA, Kisliuk RL, Gaumont Y, Sirotnak FM.
    J Med Chem; 1986 Jun 15; 29(6):1080-7. PubMed ID: 2423690
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  • 19. Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro.
    Caperelli CA, Domanico P, Benkovic SJ.
    J Med Chem; 1981 Sep 15; 24(9):1086-8. PubMed ID: 7288824
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  • 20. Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
    Gangjee A, Devraj R, McGuire JJ, Kisliuk RL.
    J Med Chem; 1995 Sep 15; 38(19):3798-805. PubMed ID: 7562910
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