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Journal Abstract Search

315 related items for PubMed ID: 25033803

  • 1. Development of EHop-016: a small molecule inhibitor of Rac.
    Dharmawardhane S, Hernandez E, Vlaar C.
    Enzymes; 2013; 33 Pt A(Pt A):117-46. PubMed ID: 25033803
    [Abstract] [Full Text] [Related]

  • 2. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
    Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S.
    J Biol Chem; 2012 Apr 13; 287(16):13228-38. PubMed ID: 22383527
    [Abstract] [Full Text] [Related]

  • 3. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.
    Castillo-Pichardo L, Humphries-Bickley T, De La Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S.
    Transl Oncol; 2014 Oct 13; 7(5):546-55. PubMed ID: 25389450
    [Abstract] [Full Text] [Related]

  • 4. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.
    Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S.
    Cancer Res Commun; 2022 Dec 13; 2(12):1711-1726. PubMed ID: 36861094
    [Abstract] [Full Text] [Related]

  • 5. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
    Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly RR, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R.
    J Clin Invest; 2013 Oct 13; 123(10):4449-63. PubMed ID: 24091327
    [Abstract] [Full Text] [Related]

  • 6. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.
    Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y.
    Proc Natl Acad Sci U S A; 2004 May 18; 101(20):7618-23. PubMed ID: 15128949
    [Abstract] [Full Text] [Related]

  • 7. Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models.
    Torres-Sanchez A, Rivera-Robles M, Castillo-Pichardo L, Martínez-Ferrer M, Dorta-Estremera SM, Dharmawardhane S.
    Front Oncol; 2023 May 18; 13():1152458. PubMed ID: 37397366
    [Abstract] [Full Text] [Related]

  • 8. Rational design and applications of a Rac GTPase-specific small molecule inhibitor.
    Akbar H, Cancelas J, Williams DA, Zheng J, Zheng Y.
    Methods Enzymol; 2006 May 18; 406():554-65. PubMed ID: 16472687
    [Abstract] [Full Text] [Related]

  • 9. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
    Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S.
    Mol Cancer Ther; 2017 May 18; 16(5):805-818. PubMed ID: 28450422
    [Abstract] [Full Text] [Related]

  • 10. Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.
    Humphries-Bickley T, Castillo-Pichardo L, Corujo-Carro F, Duconge J, Hernandez-O'Farrill E, Vlaar C, Rodriguez-Orengo JF, Cubano L, Dharmawardhane S.
    J Chromatogr B Analyt Technol Biomed Life Sci; 2015 Feb 15; 981-982():19-26. PubMed ID: 25594952
    [Abstract] [Full Text] [Related]

  • 11. Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
    Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y.
    Curr Top Med Chem; 2006 Feb 15; 6(11):1109-16. PubMed ID: 16842149
    [Abstract] [Full Text] [Related]

  • 12. Novel inhibitors of Rac1 in metastatic breast cancer.
    Hernández E, De La Mota-Peynado A, Dharmawardhane S, Vlaar CP.
    P R Health Sci J; 2010 Dec 15; 29(4):348-56. PubMed ID: 21261173
    [Abstract] [Full Text] [Related]

  • 13. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.
    Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA.
    J Biol Chem; 2015 Apr 10; 290(15):9363-76. PubMed ID: 25666619
    [Abstract] [Full Text] [Related]

  • 14. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
    Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ.
    J Biol Chem; 2007 Dec 07; 282(49):35666-78. PubMed ID: 17932039
    [Abstract] [Full Text] [Related]

  • 15. Targeting Rac and Cdc42 GEFs in Metastatic Cancer.
    Maldonado MDM, Medina JI, Velazquez L, Dharmawardhane S.
    Front Cell Dev Biol; 2020 Dec 07; 8():201. PubMed ID: 32322580
    [Abstract] [Full Text] [Related]

  • 16. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3.
    Okamoto H, Takuwa N, Yokomizo T, Sugimoto N, Sakurada S, Shigematsu H, Takuwa Y.
    Mol Cell Biol; 2000 Dec 07; 20(24):9247-61. PubMed ID: 11094076
    [Abstract] [Full Text] [Related]

  • 17. Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors.
    Lawson CD, Hornigold K, Pan D, Niewczas I, Andrews S, Clark J, Welch H.
    Small GTPases; 2022 Jan 07; 13(1):307-326. PubMed ID: 36342857
    [Abstract] [Full Text] [Related]

  • 18. Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.
    Zhou K, Wang Y, Gorski JL, Nomura N, Collard J, Bokoch GM.
    J Biol Chem; 1998 Jul 03; 273(27):16782-6. PubMed ID: 9642235
    [Abstract] [Full Text] [Related]

  • 19. The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer.
    Crespo GV, Ortiz J, O'Farrill EH, Vlaar CP, Inyushin M, Kucheryavykh Y, Kucheryavykh L.
    Mol Med; 2023 Jun 14; 29(1):75. PubMed ID: 37316799
    [Abstract] [Full Text] [Related]

  • 20. The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.
    Baird D, Feng Q, Cerione RA.
    Curr Biol; 2005 Jan 11; 15(1):1-10. PubMed ID: 15649357
    [Abstract] [Full Text] [Related]

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