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Journal Abstract Search

399 related items for PubMed ID: 25049227

  • 1. Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
    Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M.
    J Biol Chem; 2014 Sep 05; 289(36):24944-55. PubMed ID: 25049227
    [Abstract] [Full Text] [Related]

  • 2. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
    Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
    Proc Natl Acad Sci U S A; 2012 Aug 21; 109(34):13561-6. PubMed ID: 22872865
    [Abstract] [Full Text] [Related]

  • 3. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
    Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.
    Nat Cell Biol; 2010 Mar 21; 12(3):213-23. PubMed ID: 20173742
    [Abstract] [Full Text] [Related]

  • 4. Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.
    Yin S, Cao W.
    Mol Cell Biol; 2015 Aug 21; 35(15):2673-83. PubMed ID: 26012548
    [Abstract] [Full Text] [Related]

  • 5. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
    Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M.
    J Cell Biol; 2011 Apr 18; 193(2):275-84. PubMed ID: 21482715
    [Abstract] [Full Text] [Related]

  • 6. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
    Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH.
    Autophagy; 2020 Nov 18; 16(11):1949-1973. PubMed ID: 31913745
    [Abstract] [Full Text] [Related]

  • 7. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
    Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.
    Mol Cell; 2013 Sep 12; 51(5):618-31. PubMed ID: 24011591
    [Abstract] [Full Text] [Related]

  • 8. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
    Ugun-Klusek A, Tatham MH, Elkharaz J, Constantin-Teodosiu D, Lawler K, Mohamed H, Paine SM, Anderson G, John Mayer R, Lowe J, Ellen Billett E, Bedford L.
    Cell Death Dis; 2017 Jan 05; 8(1):e2531. PubMed ID: 28055010
    [Abstract] [Full Text] [Related]

  • 9. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
    Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.
    Mol Cell Biol; 2010 Jul 05; 30(13):3275-85. PubMed ID: 20421418
    [Abstract] [Full Text] [Related]

  • 10. PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.
    Park JS, Kang DH, Lee DH, Bae SH.
    Biochem Biophys Res Commun; 2015 Oct 23; 466(3):499-504. PubMed ID: 26381178
    [Abstract] [Full Text] [Related]

  • 11. Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
    Ishimura R, Tanaka K, Komatsu M.
    FEBS Lett; 2014 Mar 03; 588(5):822-8. PubMed ID: 24492006
    [Abstract] [Full Text] [Related]

  • 12. Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.
    Park JS, Kang DH, Lee DH, Bae SH.
    Biochem Biophys Res Commun; 2015 Oct 09; 466(1):131-7. PubMed ID: 26325428
    [Abstract] [Full Text] [Related]

  • 13. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
    Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T.
    J Biol Chem; 2010 Jul 16; 285(29):22576-91. PubMed ID: 20452972
    [Abstract] [Full Text] [Related]

  • 14. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
    Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q.
    Autophagy; 2010 Jul 16; 6(5):614-21. PubMed ID: 20495340
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  • 15. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A, Motohashi H.
    Nitric Oxide; 2011 Aug 01; 25(2):153-60. PubMed ID: 21385624
    [Abstract] [Full Text] [Related]

  • 16. SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.
    Darvekar SR, Elvenes J, Brenne HB, Johansen T, Sjøttem E.
    PLoS One; 2014 Aug 01; 9(1):e85262. PubMed ID: 24416372
    [Abstract] [Full Text] [Related]

  • 17. Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses.
    Bhattacharjee A, Ürmösi A, Jipa A, Kovács L, Deák P, Szabó Á, Juhász G.
    Autophagy; 2022 Oct 01; 18(10):2385-2396. PubMed ID: 35184662
    [Abstract] [Full Text] [Related]

  • 18. Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
    Park JS, Kang DH, Lee DH, Bae SH.
    Biochem Biophys Res Commun; 2015 Sep 25; 465(3):542-7. PubMed ID: 26282199
    [Abstract] [Full Text] [Related]

  • 19. Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway.
    Copple IM, Lister A, Obeng AD, Kitteringham NR, Jenkins RE, Layfield R, Foster BJ, Goldring CE, Park BK.
    J Biol Chem; 2010 May 28; 285(22):16782-8. PubMed ID: 20378532
    [Abstract] [Full Text] [Related]

  • 20. Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
    Park JS, Lee DH, Lee YS, Oh E, Bae KH, Oh KJ, Kim H, Bae SH.
    Autophagy; 2020 Jan 28; 16(1):86-105. PubMed ID: 30907226
    [Abstract] [Full Text] [Related]

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