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Journal Abstract Search

228 related items for PubMed ID: 25053626

  • 1. Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.
    Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C.
    Carcinogenesis; 2014 Oct; 35(10):2365-72. PubMed ID: 25053626
    [Abstract] [Full Text] [Related]

  • 2. Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.
    Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, Shaik AA, O'Sullivan MG, Hecht SS, Lu J, Xing C.
    Cancer Prev Res (Phila); 2014 Jan; 7(1):86-96. PubMed ID: 24403291
    [Abstract] [Full Text] [Related]

  • 3. Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice.
    Narayanapillai SC, Lin SH, Leitzman P, Upadhyaya P, Baglole CJ, Xing C.
    Chem Res Toxicol; 2016 Nov 21; 29(11):1828-1834. PubMed ID: 27728767
    [Abstract] [Full Text] [Related]

  • 4. Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice.
    Hu Q, Corral P, Narayanapillai SC, Leitzman P, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C.
    Chem Res Toxicol; 2020 Jul 20; 33(7):1980-1988. PubMed ID: 32476407
    [Abstract] [Full Text] [Related]

  • 5. Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.
    Narayanapillai SC, von Weymarn LB, Carmella SG, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy SE, Xing C.
    Drug Metab Dispos; 2016 Mar 20; 44(3):422-7. PubMed ID: 26744252
    [Abstract] [Full Text] [Related]

  • 6. Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis.
    Bian T, Ding H, Wang Y, Hu Q, Chen S, Fujioka N, Aly FZ, Lu J, Huo Z, Xing C.
    Carcinogenesis; 2022 Aug 30; 43(7):659-670. PubMed ID: 35353881
    [Abstract] [Full Text] [Related]

  • 7. Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.
    Johnson TE, Hermanson D, Wang L, Kassie F, Upadhyaya P, O'Sullivan MG, Hecht SS, Lu J, Xing C.
    Am J Chin Med; 2011 Aug 30; 39(4):727-42. PubMed ID: 21721153
    [Abstract] [Full Text] [Related]

  • 8. Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice.
    Puppala M, Narayanapillai SC, Leitzman P, Sun H, Upadhyaya P, O'Sullivan MG, Hecht SS, Xing C.
    J Med Chem; 2017 Sep 28; 60(18):7935-7940. PubMed ID: 28806079
    [Abstract] [Full Text] [Related]

  • 9. Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.
    Balbo S, Johnson CS, Kovi RC, James-Yi SA, O'Sullivan MG, Wang M, Le CT, Khariwala SS, Upadhyaya P, Hecht SS.
    Carcinogenesis; 2014 Dec 28; 35(12):2798-806. PubMed ID: 25269804
    [Abstract] [Full Text] [Related]

  • 10. The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.
    Thomson NM, Kenney PM, Peterson LA.
    Chem Res Toxicol; 2003 Jan 28; 16(1):1-6. PubMed ID: 12693024
    [Abstract] [Full Text] [Related]

  • 11. The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
    Brown BG, Richter E, Tricker AR, Ayres PH, Doolittle DJ.
    Chem Biol Interact; 2001 Nov 28; 138(2):125-35. PubMed ID: 11672696
    [Abstract] [Full Text] [Related]

  • 12. Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.
    Hecht SS, Jordan KG, Choi CI, Trushin N.
    Carcinogenesis; 1990 Jun 28; 11(6):1017-20. PubMed ID: 2347060
    [Abstract] [Full Text] [Related]

  • 13. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.
    Lao Y, Yu N, Kassie F, Villalta PW, Hecht SS.
    Chem Res Toxicol; 2007 Feb 28; 20(2):235-45. PubMed ID: 17305407
    [Abstract] [Full Text] [Related]

  • 14. Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
    Johnson TE, Kassie F, O'Sullivan MG, Negia M, Hanson TE, Upadhyaya P, Ruvolo PP, Hecht SS, Xing C.
    Cancer Prev Res (Phila); 2008 Nov 28; 1(6):430-8. PubMed ID: 19138990
    [Abstract] [Full Text] [Related]

  • 15. Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.
    Upadhyaya P, Kenney PM, Hochalter JB, Wang M, Hecht SS.
    Carcinogenesis; 1999 Aug 28; 20(8):1577-82. PubMed ID: 10426810
    [Abstract] [Full Text] [Related]

  • 16. Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Hecht SS, Kenney PM, Wang M, Trushin N, Upadhyaya P.
    Cancer Lett; 2000 Mar 13; 150(1):49-56. PubMed ID: 10755386
    [Abstract] [Full Text] [Related]

  • 17. The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers.
    Wang Y, Narayanapillai SC, Tessier KM, Strayer LG, Upadhyaya P, Hu Q, Kingston R, Salloum RG, Lu J, Hecht SS, Hatsukami DK, Fujioka N, Xing C.
    Cancer Prev Res (Phila); 2020 May 13; 13(5):483-492. PubMed ID: 32102948
    [Abstract] [Full Text] [Related]

  • 18. Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats.
    Prokopczyk B, Cox JE, Upadhyaya P, Amin S, Desai D, Hoffmann D, el-Bayoumy K.
    Carcinogenesis; 1996 Apr 13; 17(4):749-53. PubMed ID: 8625486
    [Abstract] [Full Text] [Related]

  • 19. In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice.
    Hati S, Hu Q, Huo Z, Lu J, Xing C.
    ChemMedChem; 2022 Apr 05; 17(7):e202100727. PubMed ID: 35064644
    [Abstract] [Full Text] [Related]

  • 20. A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates.
    Hecht SS, Morse MA, Eklind KI, Chung FL.
    Exp Lung Res; 1991 Apr 05; 17(2):501-11. PubMed ID: 2050046
    [Abstract] [Full Text] [Related]

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