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188 related items for PubMed ID: 25061162

  • 1. Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.
    Uchida Y, Ohtsuki S, Terasaki T.
    Drug Metab Dispos; 2014 Oct; 42(10):1719-26. PubMed ID: 25061162
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  • 3. Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice.
    Uchida Y, Ohtsuki S, Kamiie J, Terasaki T.
    J Pharmacol Exp Ther; 2011 Nov; 339(2):579-88. PubMed ID: 21828264
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  • 5. Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport.
    Sadiq MW, Uchida Y, Hoshi Y, Tachikawa M, Terasaki T, Hammarlund-Udenaes M.
    PLoS One; 2015 Nov; 10(5):e0118638. PubMed ID: 25932627
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  • 6. Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography.
    Hendrikse NH, Schinkel AH, de Vries EG, Fluks E, Van der Graaf WT, Willemsen AT, Vaalburg W, Franssen EJ.
    Br J Pharmacol; 1998 Aug; 124(7):1413-8. PubMed ID: 9723952
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  • 7. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats.
    van Vliet EA, van Schaik R, Edelbroek PM, Redeker S, Aronica E, Wadman WJ, Marchi N, Vezzani A, Gorter JA.
    Epilepsia; 2006 Apr; 47(4):672-80. PubMed ID: 16650133
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  • 8. Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin.
    Zong J, Pollack GM.
    J Pharmacol Exp Ther; 2003 Aug; 306(2):556-62. PubMed ID: 12721332
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  • 9. Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data.
    Hsiao P, Sasongko L, Link JM, Mankoff DA, Muzi M, Collier AC, Unadkat JD.
    J Pharmacol Exp Ther; 2006 May; 317(2):704-10. PubMed ID: 16415090
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  • 10. Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.
    van Vliet EA, van Schaik R, Edelbroek PM, Voskuyl RA, Redeker S, Aronica E, Wadman WJ, Gorter JA.
    J Pharmacol Exp Ther; 2007 Jul; 322(1):141-7. PubMed ID: 17392402
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  • 16. Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.
    Akazawa T, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.
    Mol Pharm; 2016 Jul 05; 13(7):2443-56. PubMed ID: 27276518
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  • 17. Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation.
    Fang W, Lv P, Geng X, Shang E, Yang Q, Sha L, Li Y.
    Neurochem Int; 2013 Jan 05; 62(1):23-30. PubMed ID: 23142723
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  • 18. Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.
    Dagenais C, Zong J, Ducharme J, Pollack GM.
    Pharm Res; 2001 Jul 05; 18(7):957-63. PubMed ID: 11496955
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