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572 related items for PubMed ID: 25096574

  • 1. B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.
    Renault TT, Elkholi R, Bharti A, Chipuk JE.
    J Biol Chem; 2014 Sep 19; 289(38):26481-26491. PubMed ID: 25096574
    [Abstract] [Full Text] [Related]

  • 2. Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.
    Liu Q, Leber B, Andrews DW.
    Cell Cycle; 2012 Oct 01; 11(19):3536-42. PubMed ID: 22895112
    [Abstract] [Full Text] [Related]

  • 3. BH3 domains other than Bim and Bid can directly activate Bax/Bak.
    Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.
    J Biol Chem; 2011 Jan 07; 286(1):491-501. PubMed ID: 21041309
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  • 4. Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
    Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A.
    J Clin Invest; 2007 Jan 07; 117(1):112-21. PubMed ID: 17200714
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  • 5. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.
    Zhang J, Huang K, O'Neill KL, Pang X, Luo X.
    Cell Death Dis; 2016 Jun 16; 7(6):e2266. PubMed ID: 27310874
    [Abstract] [Full Text] [Related]

  • 6. Small molecule inhibition of the Bcl-X(L)-BH3 protein-protein interaction: proof-of-concept of an in vivo chemopotentiator ABT-737.
    Stauffer SR.
    Curr Top Med Chem; 2007 Jun 16; 7(10):961-5. PubMed ID: 17508927
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  • 7. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
    Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.
    J Biol Chem; 2011 Apr 22; 286(16):13905-13. PubMed ID: 21367852
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  • 9. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
    Konopleva M, Milella M, Ruvolo P, Watts JC, Ricciardi MR, Korchin B, McQueen T, Bornmann W, Tsao T, Bergamo P, Mak DH, Chen W, McCubrey J, Tafuri A, Andreeff M.
    Leukemia; 2012 Apr 22; 26(4):778-87. PubMed ID: 22064351
    [Abstract] [Full Text] [Related]

  • 10. BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
    Hikita H, Takehara T, Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N.
    Hepatology; 2009 Dec 22; 50(6):1972-80. PubMed ID: 19839062
    [Abstract] [Full Text] [Related]

  • 11. Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.
    Shamas-Din A, Bindner S, Chi X, Leber B, Andrews DW, Fradin C.
    Biochem J; 2015 May 01; 467(3):495-505. PubMed ID: 25714678
    [Abstract] [Full Text] [Related]

  • 12. Examining BCL-2 family function with large unilamellar vesicles.
    Asciolla JJ, Renault TT, Chipuk JE.
    J Vis Exp; 2012 Oct 05; (68):. PubMed ID: 23070252
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  • 16. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.
    Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A.
    Cancer Cell; 2006 May 05; 9(5):351-65. PubMed ID: 16697956
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  • 17. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.
    Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A.
    Blood; 2008 Feb 15; 111(4):2300-9. PubMed ID: 18056841
    [Abstract] [Full Text] [Related]

  • 18. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
    Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD.
    Mol Cell; 2005 Feb 18; 17(4):525-35. PubMed ID: 15721256
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  • 20. Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.
    Buron N, Porceddu M, Brabant M, Desgué D, Racoeur C, Lassalle M, Péchoux C, Rustin P, Jacotot E, Borgne-Sanchez A.
    PLoS One; 2010 Mar 31; 5(3):e9924. PubMed ID: 20360986
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