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1122 related items for PubMed ID: 25103499

  • 1. A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.
    Joshi S, Singh AR, Zulcic M, Durden DL.
    Mol Cancer Res; 2014 Oct; 12(10):1520-31. PubMed ID: 25103499
    [Abstract] [Full Text] [Related]

  • 2. MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.
    Joshi S, Singh AR, Durden DL.
    J Biol Chem; 2014 Aug 15; 289(33):22785-22797. PubMed ID: 24982421
    [Abstract] [Full Text] [Related]

  • 3. PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.
    Fang J, Ding M, Yang L, Liu LZ, Jiang BH.
    Cell Signal; 2007 Dec 15; 19(12):2487-97. PubMed ID: 17826033
    [Abstract] [Full Text] [Related]

  • 4. Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.
    Chen MC, Lee CF, Huang WH, Chou TC.
    Biochem Pharmacol; 2013 May 01; 85(9):1278-87. PubMed ID: 23416116
    [Abstract] [Full Text] [Related]

  • 5. Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF-dependent angiogenesis.
    Raja R, Kale S, Thorat D, Soundararajan G, Lohite K, Mane A, Karnik S, Kundu GC.
    Oncogene; 2014 Apr 17; 33(16):2053-64. PubMed ID: 23728336
    [Abstract] [Full Text] [Related]

  • 6. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
    Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL.
    Cancer Res; 2000 Mar 15; 60(6):1541-5. PubMed ID: 10749120
    [Abstract] [Full Text] [Related]

  • 7. Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells.
    Sun YZ, Cai N, Liu NN.
    Cell Physiol Biochem; 2017 Mar 15; 44(4):1640-1650. PubMed ID: 29216640
    [Abstract] [Full Text] [Related]

  • 8. PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma.
    Mohlin S, Hamidian A, von Stedingk K, Bridges E, Wigerup C, Bexell D, Påhlman S.
    Cancer Res; 2015 Nov 01; 75(21):4617-28. PubMed ID: 26432405
    [Abstract] [Full Text] [Related]

  • 9. 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells.
    Gao N, Nester RA, Sarkar MA.
    Toxicol Appl Pharmacol; 2004 Apr 01; 196(1):124-35. PubMed ID: 15050414
    [Abstract] [Full Text] [Related]

  • 10. Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway.
    Park JH, Lee JY, Shin DH, Jang KS, Kim HJ, Kong G.
    Oncogene; 2011 Nov 10; 30(45):4578-89. PubMed ID: 21602890
    [Abstract] [Full Text] [Related]

  • 11. KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation.
    Ci X, Xing C, Zhang B, Zhang Z, Ni JJ, Zhou W, Dong JT.
    Mol Cancer; 2015 Apr 21; 14():91. PubMed ID: 25896712
    [Abstract] [Full Text] [Related]

  • 12. Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis.
    DeNiro M, Alsmadi O, Al-Mohanna F.
    Exp Eye Res; 2009 Nov 21; 89(5):700-17. PubMed ID: 19580810
    [Abstract] [Full Text] [Related]

  • 13. Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.
    Park SS, Bae I, Lee YJ.
    J Cell Biochem; 2008 Apr 15; 103(6):1989-98. PubMed ID: 17973296
    [Abstract] [Full Text] [Related]

  • 14. MFTZ-1 reduces constitutive and inducible HIF-1α accumulation and VEGF secretion independent of its topoisomerase II inhibition.
    Dai M, Miao ZH, Ren X, Tong LJ, Yang N, Li T, Lin LP, Shen YM, Ding J.
    J Cell Mol Med; 2010 Sep 15; 14(9):2281-91. PubMed ID: 19538463
    [Abstract] [Full Text] [Related]

  • 15. PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.
    Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, Takahashi H, Wakasugi T, Takeyama H.
    Mol Cell Biochem; 2009 Nov 15; 331(1-2):161-71. PubMed ID: 19437103
    [Abstract] [Full Text] [Related]

  • 16. Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells.
    Tomita M, Semenza GL, Michiels C, Matsuda T, Uchihara JN, Okudaira T, Tanaka Y, Taira N, Ohshiro K, Mori N.
    Biochem J; 2007 Sep 01; 406(2):317-23. PubMed ID: 17576198
    [Abstract] [Full Text] [Related]

  • 17. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway.
    Kazi AA, Koos RD.
    Endocrinology; 2007 May 01; 148(5):2363-74. PubMed ID: 17272396
    [Abstract] [Full Text] [Related]

  • 18. Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma.
    Li Y, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY.
    Gastroenterology; 2014 Jun 01; 146(7):1701-13.e9. PubMed ID: 24561231
    [Abstract] [Full Text] [Related]

  • 19. Notoginsenoside Ft1 promotes angiogenesis via HIF-1α mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways.
    Shen K, Ji L, Gong C, Ma Y, Yang L, Fan Y, Hou M, Wang Z.
    Biochem Pharmacol; 2012 Sep 15; 84(6):784-92. PubMed ID: 22771629
    [Abstract] [Full Text] [Related]

  • 20. Pharmacologic stabilization of hypoxia-inducible transcription factors protects developing mouse brain from hypoxia-induced apoptotic cell death.
    Trollmann R, Richter M, Jung S, Walkinshaw G, Brackmann F.
    Neuroscience; 2014 Oct 10; 278():327-42. PubMed ID: 25162122
    [Abstract] [Full Text] [Related]

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