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249 related items for PubMed ID: 25112875

  • 1. The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.
    Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor SS.
    J Biol Chem; 2014 Oct 10; 289(41):28505-12. PubMed ID: 25112875
    [Abstract] [Full Text] [Related]

  • 2. Structure and allostery of the PKA RIIβ tetrameric holoenzyme.
    Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS.
    Science; 2012 Feb 10; 335(6069):712-6. PubMed ID: 22323819
    [Abstract] [Full Text] [Related]

  • 3. Probing cAMP-dependent protein kinase holoenzyme complexes I alpha and II beta by FT-IR and chemical protein footprinting.
    Yu S, Mei FC, Lee JC, Cheng X.
    Biochemistry; 2004 Feb 24; 43(7):1908-20. PubMed ID: 14967031
    [Abstract] [Full Text] [Related]

  • 4. Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
    Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS.
    PLoS Biol; 2020 Dec 24; 18(12):e3001018. PubMed ID: 33370777
    [Abstract] [Full Text] [Related]

  • 5. Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.
    Brown SH, Wu J, Kim C, Alberto K, Taylor SS.
    J Mol Biol; 2009 Nov 13; 393(5):1070-82. PubMed ID: 19748511
    [Abstract] [Full Text] [Related]

  • 6. Differential effects of substrate on type I and type II PKA holoenzyme dissociation.
    Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J.
    Biochemistry; 2004 May 18; 43(19):5629-36. PubMed ID: 15134437
    [Abstract] [Full Text] [Related]

  • 7. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.
    Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J.
    J Mol Biol; 2004 Apr 09; 337(5):1183-94. PubMed ID: 15046986
    [Abstract] [Full Text] [Related]

  • 8. Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP.
    Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS.
    Proc Natl Acad Sci U S A; 2019 Aug 13; 116(33):16347-16356. PubMed ID: 31363049
    [Abstract] [Full Text] [Related]

  • 9. Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme.
    Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS.
    Structure; 2011 Feb 09; 19(2):265-76. PubMed ID: 21300294
    [Abstract] [Full Text] [Related]

  • 10. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.
    Vigil D, Blumenthal DK, Taylor SS, Trewhella J.
    J Biol Chem; 2005 Oct 21; 280(42):35521-7. PubMed ID: 16109722
    [Abstract] [Full Text] [Related]

  • 11. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms.
    Vigil D, Blumenthal DK, Taylor SS, Trewhella J.
    J Mol Biol; 2006 Mar 31; 357(3):880-9. PubMed ID: 16460759
    [Abstract] [Full Text] [Related]

  • 12. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP.
    Zawadzki KM, Taylor SS.
    J Biol Chem; 2004 Feb 20; 279(8):7029-36. PubMed ID: 14625280
    [Abstract] [Full Text] [Related]

  • 13. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.
    Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS.
    Structure; 2015 Sep 01; 23(9):1563-1572. PubMed ID: 26278174
    [Abstract] [Full Text] [Related]

  • 14. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change.
    Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J.
    J Biol Chem; 2004 Apr 30; 279(18):19084-90. PubMed ID: 14985329
    [Abstract] [Full Text] [Related]

  • 15. The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II.
    Ventra C, Porcellini A, Feliciello A, Gallo A, Paolillo M, Mele E, Avvedimento VE, Schettini G.
    J Neurochem; 1996 Apr 30; 66(4):1752-61. PubMed ID: 8627334
    [Abstract] [Full Text] [Related]

  • 16. Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.
    Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS.
    PLoS Biol; 2015 Jul 30; 13(7):e1002192. PubMed ID: 26158466
    [Abstract] [Full Text] [Related]

  • 17. Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS).
    Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor SS, Woods VL.
    J Mol Biol; 2004 Jul 23; 340(5):1185-96. PubMed ID: 15236976
    [Abstract] [Full Text] [Related]

  • 18. PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.
    Calebiro D, Hannawacker A, Lyga S, Bathon K, Zabel U, Ronchi C, Beuschlein F, Reincke M, Lorenz K, Allolio B, Kisker C, Fassnacht M, Lohse MJ.
    Nat Commun; 2014 Dec 05; 5():5680. PubMed ID: 25477193
    [Abstract] [Full Text] [Related]

  • 19. Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering.
    Cheng CY, Yang J, Taylor SS, Blumenthal DK.
    J Biol Chem; 2009 Dec 18; 284(51):35916-25. PubMed ID: 19837668
    [Abstract] [Full Text] [Related]

  • 20. Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS).
    Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD, Taylor SS, Woods VL.
    Protein Sci; 2003 Sep 18; 12(9):1980-90. PubMed ID: 12930997
    [Abstract] [Full Text] [Related]

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