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Journal Abstract Search

479 related items for PubMed ID: 25145583

  • 1. 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
    Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo MG, Liu Y, Gui B, Sini M, Smith JW, Dombrowski F, Calvisi DF, Evert M, Chen X.
    Hepatology; 2015 Jan; 61(1):200-13. PubMed ID: 25145583
    [Abstract] [Full Text] [Related]

  • 2. Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: implications for the treatment of human liver cancer.
    Wang C, Cigliano A, Delogu S, Armbruster J, Dombrowski F, Evert M, Chen X, Calvisi DF.
    Cell Cycle; 2013 Jul 01; 12(13):1999-2010. PubMed ID: 23759595
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  • 5. Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.
    George A, Panda S, Kudmulwar D, Chhatbar SP, Nayak SC, Krishnan HH.
    J Biol Chem; 2012 Feb 10; 287(7):5042-58. PubMed ID: 22184107
    [Abstract] [Full Text] [Related]

  • 6. Phosphorylation of eukaryotic translation initiation factor 4E and eukaryotic translation initiation factor 4E-binding protein (4EBP) and their upstream signaling components undergo diurnal oscillation in the mouse hippocampus: implications for memory persistence.
    Saraf A, Luo J, Morris DR, Storm DR.
    J Biol Chem; 2014 Jul 18; 289(29):20129-38. PubMed ID: 24895127
    [Abstract] [Full Text] [Related]

  • 7. AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
    Ho C, Wang C, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X, Calvisi DF.
    Hepatology; 2012 Mar 18; 55(3):833-45. PubMed ID: 21993994
    [Abstract] [Full Text] [Related]

  • 8. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.
    Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF.
    Cell Death Dis; 2014 Mar 13; 5(3):e1114. PubMed ID: 24625973
    [Abstract] [Full Text] [Related]

  • 9. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.
    Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X.
    Hepatology; 2017 Jul 13; 66(1):167-181. PubMed ID: 28370287
    [Abstract] [Full Text] [Related]

  • 10. Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion.
    Chen L, Xu B, Liu L, Liu C, Luo Y, Chen X, Barzegar M, Chung J, Huang S.
    Oncotarget; 2015 Mar 30; 6(9):7136-50. PubMed ID: 25762619
    [Abstract] [Full Text] [Related]

  • 11. RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.
    Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.
    Cell Signal; 2014 Mar 30; 26(3):461-7. PubMed ID: 24316235
    [Abstract] [Full Text] [Related]

  • 12. Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.
    Bommer UA, Iadevaia V, Chen J, Knoch B, Engel M, Proud CG.
    Cell Signal; 2015 Aug 30; 27(8):1557-68. PubMed ID: 25936523
    [Abstract] [Full Text] [Related]

  • 13. Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy.
    Xu J, Chen J, Dong Z, Meyuhas O, Chen JK.
    Kidney Int; 2015 Mar 30; 87(3):543-56. PubMed ID: 25229342
    [Abstract] [Full Text] [Related]

  • 14. Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway.
    Nathan CO, Amirghahari N, Abreo F, Rong X, Caldito G, Jones ML, Zhou H, Smith M, Kimberly D, Glass J.
    Clin Cancer Res; 2004 Sep 01; 10(17):5820-7. PubMed ID: 15355912
    [Abstract] [Full Text] [Related]

  • 15. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.
    Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M.
    Gastroenterology; 2011 Mar 01; 140(3):1071-83. PubMed ID: 21147110
    [Abstract] [Full Text] [Related]

  • 16. Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells.
    Zeng Q, Qin S, Zhang H, Liu B, Qin J, Wang X, Zhang R, Liu C, Dong X, Zhang S, Huang S, Chen L.
    J Cell Physiol; 2018 Jan 01; 233(1):516-529. PubMed ID: 28300280
    [Abstract] [Full Text] [Related]

  • 17. Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway.
    Palaniappan M, Menon KM.
    Mol Endocrinol; 2010 Sep 01; 24(9):1782-93. PubMed ID: 20660299
    [Abstract] [Full Text] [Related]

  • 18. Transforming Growth Factor β1-induced Apoptosis in Podocytes via the Extracellular Signal-regulated Kinase-Mammalian Target of Rapamycin Complex 1-NADPH Oxidase 4 Axis.
    Das R, Xu S, Nguyen TT, Quan X, Choi SK, Kim SJ, Lee EY, Cha SK, Park KS.
    J Biol Chem; 2015 Dec 25; 290(52):30830-42. PubMed ID: 26565025
    [Abstract] [Full Text] [Related]

  • 19. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.
    Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS.
    Oncogene; 2014 Mar 20; 33(12):1590-600. PubMed ID: 23542178
    [Abstract] [Full Text] [Related]

  • 20. Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E.
    ur Rasool R, Rah B, Amin H, Nayak D, Chakraborty S, Rawoof A, Mintoo MJ, Yousuf K, Mukherjee D, Kumar LD, Mondhe DM, Goswami A.
    Sci Rep; 2016 Jan 05; 6():18800. PubMed ID: 26728896
    [Abstract] [Full Text] [Related]

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