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196 related items for PubMed ID: 25159986

  • 1. Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.
    Heyninck K, Lahtela-Kakkonen M, Van der Veken P, Haegeman G, Vanden Berghe W.
    Biochem Pharmacol; 2014 Oct 15; 91(4):501-9. PubMed ID: 25159986
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.
    Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.
    BMC Genomics; 2010 Dec 02; 11 Suppl 4(Suppl 4):S25. PubMed ID: 21143809
    [Abstract] [Full Text] [Related]

  • 3. Thiol dependent NF-κB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A.
    Gambhir L, Checker R, Sharma D, Thoh M, Patil A, Degani M, Gota V, Sandur SK.
    Toxicol Appl Pharmacol; 2015 Dec 01; 289(2):297-312. PubMed ID: 26408225
    [Abstract] [Full Text] [Related]

  • 4. Artemisolide is a typical inhibitor of IkappaB kinase beta targeting cysteine-179 residue and down-regulates NF-kappaB-dependent TNF-alpha expression in LPS-activated macrophages.
    Kim BH, Lee JY, Seo JH, Lee HY, Ryu SY, Ahn BW, Lee CK, Hwang BY, Han SB, Kim Y.
    Biochem Biophys Res Commun; 2007 Sep 28; 361(3):593-8. PubMed ID: 17669364
    [Abstract] [Full Text] [Related]

  • 5. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
    Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB.
    Cancer Res; 2008 Jul 01; 68(13):5370-9. PubMed ID: 18593939
    [Abstract] [Full Text] [Related]

  • 6. N-tosyl-L-phenylalanine chloromethyl ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB kinase beta and p65/RelA.
    Ha KH, Byun MS, Choi J, Jeong J, Lee KJ, Jue DM.
    Biochemistry; 2009 Aug 04; 48(30):7271-8. PubMed ID: 19591457
    [Abstract] [Full Text] [Related]

  • 7. GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase.
    Kim YL, Kim JE, Shin KJ, Lee S, Ahn C, Chung J, Kim DH, Seong JY, Hwang JI.
    Cell Signal; 2008 Nov 04; 20(11):2127-33. PubMed ID: 18755269
    [Abstract] [Full Text] [Related]

  • 8. Regulation and function of IKK and IKK-related kinases.
    Häcker H, Karin M.
    Sci STKE; 2006 Oct 17; 2006(357):re13. PubMed ID: 17047224
    [Abstract] [Full Text] [Related]

  • 9. Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.
    Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H.
    J Immunol; 2011 Sep 01; 187(5):2202-12. PubMed ID: 21810613
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.
    Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD.
    Biochem Pharmacol; 2006 Feb 28; 71(5):634-45. PubMed ID: 16360644
    [Abstract] [Full Text] [Related]

  • 11. Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation.
    Zhang D, Wang X, Chen S, Chen S, Yu W, Liu X, Yang G, Tao Y, Tang X, Bu D, Zhang H, Kong W, Tang C, Huang Y, Du J, Jin H.
    Clin Sci (Lond); 2019 Oct 30; 133(20):2045-2059. PubMed ID: 31654061
    [Abstract] [Full Text] [Related]

  • 12. Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.
    Tse AK, Wan CK, Shen XL, Yang M, Fong WF.
    Biochem Pharmacol; 2005 Nov 15; 70(10):1443-57. PubMed ID: 16181613
    [Abstract] [Full Text] [Related]

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  • 14. IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.
    Schmid JA, Birbach A.
    Cytokine Growth Factor Rev; 2008 Apr 15; 19(2):157-65. PubMed ID: 18308615
    [Abstract] [Full Text] [Related]

  • 15. A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.
    Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L, Hepperle M, Harriman G, Jaffee BD, Ocain TD, Xu Y.
    J Pharmacol Exp Ther; 2006 Jun 15; 317(3):989-1001. PubMed ID: 16525037
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase.
    Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M.
    J Biol Chem; 2000 Nov 17; 275(46):36062-6. PubMed ID: 10967126
    [Abstract] [Full Text] [Related]

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  • 18. Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production.
    Tsai J, Zhang R, Qiu W, Su Q, Naples M, Adeli K.
    Am J Physiol Gastrointest Liver Physiol; 2009 Jun 17; 296(6):G1287-98. PubMed ID: 19342510
    [Abstract] [Full Text] [Related]

  • 19. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling.
    Jackson SS, Oberley C, Hooper CP, Grindle K, Wuerzberger-Davis S, Wolff J, McCool K, Rui L, Miyamoto S.
    Exp Cell Res; 2015 Feb 01; 331(1):58-72. PubMed ID: 25304104
    [Abstract] [Full Text] [Related]

  • 20. Epithelial NEMO links innate immunity to chronic intestinal inflammation.
    Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M.
    Nature; 2007 Mar 29; 446(7135):557-61. PubMed ID: 17361131
    [Abstract] [Full Text] [Related]

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