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Journal Abstract Search

209 related items for PubMed ID: 25228500

  • 1. Effects of L-type calcium channel and human ether-a-go-go related gene blockers on the electrical activity of the human heart: a simulation study.
    Zemzemi N, Rodriguez B.
    Europace; 2015 Feb; 17(2):326-33. PubMed ID: 25228500
    [Abstract] [Full Text] [Related]

  • 2. Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs.
    Kim JG, Sung DJ, Kim HJ, Park SW, Won KJ, Kim B, Shin HC, Kim KS, Leem CH, Zhang YH, Cho H, Bae YM.
    PLoS One; 2016 Feb; 11(3):e0149198. PubMed ID: 26930604
    [Abstract] [Full Text] [Related]

  • 3. The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications.
    Thomas D, Karle CA, Kiehn J.
    Curr Pharm Des; 2006 Feb; 12(18):2271-83. PubMed ID: 16787254
    [Abstract] [Full Text] [Related]

  • 4. Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.
    Witchel HJ, Hancox JC.
    Clin Exp Pharmacol Physiol; 2000 Oct; 27(10):753-66. PubMed ID: 11022966
    [Abstract] [Full Text] [Related]

  • 5. Different voltage dependence of ICaL blockade in nonselective IKr blockers causes their opposite effects on early afterdepolarization in drug-induced arrhythmia.
    Kimura A, Murakami S.
    J Pharmacol Sci; 2021 Sep; 147(1):95-103. PubMed ID: 34294379
    [Abstract] [Full Text] [Related]

  • 6. Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials.
    Zemzemi N, Bernabeu MO, Saiz J, Cooper J, Pathmanathan P, Mirams GR, Pitt-Francis J, Rodriguez B.
    Br J Pharmacol; 2013 Feb; 168(3):718-33. PubMed ID: 22946617
    [Abstract] [Full Text] [Related]

  • 7. Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization.
    Odening KE, Hyder O, Chaves L, Schofield L, Brunner M, Kirk M, Zehender M, Peng X, Koren G.
    Am J Physiol Heart Circ Physiol; 2008 Dec; 295(6):H2264-72. PubMed ID: 18835916
    [Abstract] [Full Text] [Related]

  • 8. In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity.
    De Clerck F, Van de Water A, D'Aubioul J, Lu HR, van Rossem K, Hermans A, Van Ammel K.
    Fundam Clin Pharmacol; 2002 Apr; 16(2):125-40. PubMed ID: 12031065
    [Abstract] [Full Text] [Related]

  • 9. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.
    Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE.
    Circ Res; 2013 Sep 13; 113(7):e50-e61. PubMed ID: 23897695
    [Abstract] [Full Text] [Related]

  • 10. hERG inhibitors with similar potency but different binding kinetics do not pose the same proarrhythmic risk: implications for drug safety assessment.
    DI Veroli GY, Davies MR, Zhang H, Abi-Gerges N, Boyett MR.
    J Cardiovasc Electrophysiol; 2014 Feb 13; 25(2):197-207. PubMed ID: 24118558
    [Abstract] [Full Text] [Related]

  • 11. Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes.
    Loewe A, Wilhelms M, Fischer F, Scholz EP, Dössel O, Seemann G.
    Europace; 2014 Mar 13; 16(3):435-43. PubMed ID: 24569898
    [Abstract] [Full Text] [Related]

  • 12. Liposomes ameliorate Crizotinib- and Nilotinib-induced inhibition of the cardiac IKr channel and QTc prolongation.
    Shopp GM, Helson L, Bouchard A, Salvail D, Majeed M.
    Anticancer Res; 2014 Sep 13; 34(9):4733-40. PubMed ID: 25202051
    [Abstract] [Full Text] [Related]

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  • 15. Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome.
    Yue Y, Castrichini M, Srivastava U, Fabris F, Shah K, Li Z, Qu Y, El-Sherif N, Zhou Z, January C, Hussain MM, Jiang XC, Sobie EA, Wahren-Herlenius M, Chahine M, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M.
    Circulation; 2015 Jul 28; 132(4):230-40. PubMed ID: 25995318
    [Abstract] [Full Text] [Related]

  • 16. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.
    Romero L, Trenor B, Yang PC, Saiz J, Clancy CE.
    J Mol Cell Cardiol; 2014 Jul 28; 72():126-37. PubMed ID: 24631769
    [Abstract] [Full Text] [Related]

  • 17. Mechanism of action potential prolongation by RP 58866 and its active enantiomer, terikalant. Block of the rapidly activating delayed rectifier K+ current, IKr.
    Jurkiewicz NK, Wang J, Fermini B, Sanguinetti MC, Salata JJ.
    Circulation; 1996 Dec 01; 94(11):2938-46. PubMed ID: 8941124
    [Abstract] [Full Text] [Related]

  • 18. The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.
    Shi YP, Pang Z, Venkateshappa R, Gunawan M, Kemp J, Truong E, Chang C, Lin E, Shafaattalab S, Faizi S, Rayani K, Tibbits GF, Claydon VE, Claydon TW.
    Am J Physiol Heart Circ Physiol; 2020 Aug 01; 319(2):H251-H261. PubMed ID: 32559136
    [Abstract] [Full Text] [Related]

  • 19. The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors.
    Hisajima N, Hata Y, Kinoshita K, Fukushima T, Nishida N, Kano M, Tabata T.
    Biol Pharm Bull; 2015 Aug 01; 38(5):781-4. PubMed ID: 25947924
    [Abstract] [Full Text] [Related]

  • 20. Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models.
    Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T.
    Am J Physiol Heart Circ Physiol; 2017 Jan 01; 312(1):H106-H127. PubMed ID: 27836893
    [Abstract] [Full Text] [Related]

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