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271 related items for PubMed ID: 25271156

  • 1. Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.
    Chen X, Bai B, Tian Y, Du H, Chen J.
    J Biol Chem; 2014 Nov 07; 289(45):31173-87. PubMed ID: 25271156
    [Abstract] [Full Text] [Related]

  • 2. Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction.
    Chen J, Chen X, Li S, Jiang Y, Mao H, Zhang R, Ji B, Yan M, Cai X, Wang C.
    Redox Biol; 2020 Sep 07; 36():101629. PubMed ID: 32863206
    [Abstract] [Full Text] [Related]

  • 3. GPCR structure and function relationship: identification of a biased apelin receptor mutant.
    Ban T, Li X, Ma X, Yang H, Song Y, Sun Y, Shen M, Li N, Zhang MY, Ma Y, Zhong W, Zhang M, Hu LA.
    Biochem J; 2018 Dec 06; 475(23):3813-3826. PubMed ID: 30409826
    [Abstract] [Full Text] [Related]

  • 4. Heterodimerization of apelin and opioid receptor-like 1 receptors mediates apelin-13-induced G protein biased signaling.
    Chen J, Wang Z, Zhang R, Yin H, Wang P, Wang C, Jiang Y.
    Life Sci; 2023 Sep 01; 328():121892. PubMed ID: 37364634
    [Abstract] [Full Text] [Related]

  • 5. Apelin binding to human APJ receptor leads to biased signaling.
    Kumar P, Ashokan A, Aradhyam GK.
    Biochim Biophys Acta; 2016 Dec 01; 1864(12):1748-1756. PubMed ID: 27671350
    [Abstract] [Full Text] [Related]

  • 6. Agonist-induced internalization and desensitization of the apelin receptor.
    Pope GR, Tilve S, McArdle CA, Lolait SJ, O'Carroll AM.
    Mol Cell Endocrinol; 2016 Dec 05; 437():108-119. PubMed ID: 27492965
    [Abstract] [Full Text] [Related]

  • 7. In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure.
    Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, Crain E, St-Onge S, Héroux M, Bouvier M, Xu C, Chen XQ, Generaux C, Lawrence M, Wexler R, Gordon D.
    Circ Heart Fail; 2021 Mar 05; 14(3):e007351. PubMed ID: 33663236
    [Abstract] [Full Text] [Related]

  • 8. Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats.
    Coquerel D, Delile E, Dumont L, Chagnon F, Murza A, Sainsily X, Salvail D, Sarret P, Marsault E, Auger-Messier M, Lesur O.
    Am J Physiol Heart Circ Physiol; 2021 Apr 01; 320(4):H1646-H1656. PubMed ID: 33635165
    [Abstract] [Full Text] [Related]

  • 9. The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.
    Zhou N, Zhang X, Fan X, Argyris E, Fang J, Acheampong E, DuBois GC, Pomerantz RJ.
    Virology; 2003 Dec 05; 317(1):84-94. PubMed ID: 14675627
    [Abstract] [Full Text] [Related]

  • 10. Heterodimerization of human apelin and bradykinin 1 receptors: novel signal transduction characteristics.
    Bai B, Liu L, Zhang N, Wang C, Jiang Y, Chen J.
    Cell Signal; 2014 Jul 05; 26(7):1549-59. PubMed ID: 24686079
    [Abstract] [Full Text] [Related]

  • 11. Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via Gαq-mediated mechanism.
    Bai B, Cai X, Jiang Y, Karteris E, Chen J.
    J Cell Mol Med; 2014 Oct 05; 18(10):2071-81. PubMed ID: 25164432
    [Abstract] [Full Text] [Related]

  • 12. Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine.
    Ceraudo E, Galanth C, Carpentier E, Banegas-Font I, Schonegge AM, Alvear-Perez R, Iturrioz X, Bouvier M, Llorens-Cortes C.
    J Biol Chem; 2014 Aug 29; 289(35):24599-610. PubMed ID: 25012663
    [Abstract] [Full Text] [Related]

  • 13. Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice.
    Li N, Ma X, Ban T, Xu S, Ma Y, Ason B, Hu LA.
    Biochem J; 2020 Sep 18; 477(17):3313-3327. PubMed ID: 32779693
    [Abstract] [Full Text] [Related]

  • 14. By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.
    Iturrioz X, Gerbier R, Leroux V, Alvear-Perez R, Maigret B, Llorens-Cortes C.
    J Biol Chem; 2010 Oct 15; 285(42):32627-37. PubMed ID: 20675385
    [Abstract] [Full Text] [Related]

  • 15. Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
    Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ.
    Circ Res; 2013 Jun 21; 113(1):22-31. PubMed ID: 23603510
    [Abstract] [Full Text] [Related]

  • 16. APJ acts as a dual receptor in cardiac hypertrophy.
    Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P.
    Nature; 2012 Aug 16; 488(7411):394-8. PubMed ID: 22810587
    [Abstract] [Full Text] [Related]

  • 17. The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.
    Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.
    Pharmacol Res; 2018 May 16; 131():7-16. PubMed ID: 29530600
    [Abstract] [Full Text] [Related]

  • 18. Apelin and APJ orchestrate complex tissue-specific control of cardiomyocyte hypertrophy and contractility in the hypertrophy-heart failure transition.
    Parikh VN, Liu J, Shang C, Woods C, Chang AC, Zhao M, Charo DN, Grunwald Z, Huang Y, Seo K, Tsao PS, Bernstein D, Ruiz-Lozano P, Quertermous T, Ashley EA.
    Am J Physiol Heart Circ Physiol; 2018 Aug 01; 315(2):H348-H356. PubMed ID: 29775410
    [Abstract] [Full Text] [Related]

  • 19. The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles.
    Jiang Y, Yan M, Wang C, Wang Q, Chen X, Zhang R, Wan L, Ji B, Dong B, Wang H, Chen J.
    Front Pharmacol; 2021 Aug 01; 12():630548. PubMed ID: 33746758
    [Abstract] [Full Text] [Related]

  • 20. Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.
    Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD.
    J Biol Chem; 2017 Feb 03; 292(5):1925-1933. PubMed ID: 27994053
    [Abstract] [Full Text] [Related]

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