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1006 related items for PubMed ID: 25282654

  • 1. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Lan JS, Xie SS, Li SY, Pan LF, Wang XB, Kong LY.
    Bioorg Med Chem; 2014 Nov 01; 22(21):6089-104. PubMed ID: 25282654
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
    Thiratmatrakul S, Yenjai C, Waiwut P, Vajragupta O, Reubroycharoen P, Tohda M, Boonyarat C.
    Eur J Med Chem; 2014 Mar 21; 75():21-30. PubMed ID: 24508831
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    Xie SS, Wang XB, Li JY, Yang L, Kong LY.
    Eur J Med Chem; 2013 Jun 21; 64():540-53. PubMed ID: 23685572
    [Abstract] [Full Text] [Related]

  • 4. O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.
    Mao F, Huang L, Luo Z, Liu A, Lu C, Xie Z, Li X.
    Bioorg Med Chem; 2012 Oct 01; 20(19):5884-92. PubMed ID: 22944335
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
    Lan JS, Zhang T, Liu Y, Yang J, Xie SS, Liu J, Miao ZY, Ding Y.
    Eur J Med Chem; 2017 Jun 16; 133():184-196. PubMed ID: 28388521
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
    Wang J, Wang ZM, Li XM, Li F, Wu JJ, Kong LY, Wang XB.
    Bioorg Med Chem; 2016 Sep 15; 24(18):4324-4338. PubMed ID: 27460699
    [Abstract] [Full Text] [Related]

  • 7. Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
    Xie SS, Lan JS, Wang XB, Jiang N, Dong G, Li ZR, Wang KD, Guo PP, Kong LY.
    Eur J Med Chem; 2015 Mar 26; 93():42-50. PubMed ID: 25656088
    [Abstract] [Full Text] [Related]

  • 8. Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
    Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, López MG, Wehle S, Gharbi T, Refouvelet B, de Andrés L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodríguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L.
    ChemMedChem; 2015 Mar 26; 10(3):523-39. PubMed ID: 25537267
    [Abstract] [Full Text] [Related]

  • 9. Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
    Fernández-Bachiller MI, Pérez C, González-Muñoz GC, Conde S, López MG, Villarroya M, García AG, Rodríguez-Franco MI.
    J Med Chem; 2010 Jul 08; 53(13):4927-37. PubMed ID: 20545360
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
    Liao S, Deng H, Huang S, Yang J, Wang S, Yin B, Zheng T, Zhang D, Liu J, Gao G, Ma J, Deng Z.
    Bioorg Med Chem Lett; 2015 Apr 01; 25(7):1541-5. PubMed ID: 25724825
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives.
    Riazimontazer E, Sadeghpour H, Nadri H, Sakhteman A, Tüylü Küçükkılınç T, Miri R, Edraki N.
    Bioorg Chem; 2019 Aug 01; 89():103006. PubMed ID: 31158577
    [Abstract] [Full Text] [Related]

  • 12. Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer's Disease.
    Fu Y, Mu Y, Lei H, Wang P, Li X, Leng Q, Han L, Qu X, Wang Z, Huang X.
    Molecules; 2016 Oct 11; 21(10):. PubMed ID: 27727187
    [Abstract] [Full Text] [Related]

  • 13. Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
    Tang H, Zhao LZ, Zhao HT, Huang SL, Zhong SM, Qin JK, Chen ZF, Huang ZS, Liang H.
    Eur J Med Chem; 2011 Oct 11; 46(10):4970-9. PubMed ID: 21871694
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
    Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S, Pi R.
    Bioorg Med Chem Lett; 2012 Oct 15; 22(20):6498-502. PubMed ID: 22981331
    [Abstract] [Full Text] [Related]

  • 15. Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.
    Manral A, Saini V, Meena P, Tiwari M.
    Bioorg Med Chem; 2015 Oct 01; 23(19):6389-403. PubMed ID: 26337018
    [Abstract] [Full Text] [Related]

  • 16. Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
    Zhu J, Yang H, Chen Y, Lin H, Li Q, Mo J, Bian Y, Pei Y, Sun H.
    J Enzyme Inhib Med Chem; 2018 Dec 01; 33(1):496-506. PubMed ID: 29405075
    [Abstract] [Full Text] [Related]

  • 17. Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.
    Li SY, Wang XB, Xie SS, Jiang N, Wang KD, Yao HQ, Sun HB, Kong LY.
    Eur J Med Chem; 2013 Nov 01; 69():632-46. PubMed ID: 24095756
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Li SY, Jiang N, Xie SS, Wang KD, Wang XB, Kong LY.
    Org Biomol Chem; 2014 Feb 07; 12(5):801-14. PubMed ID: 24310227
    [Abstract] [Full Text] [Related]

  • 19. New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease.
    Chufarova N, Czarnecka K, Skibiński R, Cuchra M, Majsterek I, Szymański P.
    Arch Pharm (Weinheim); 2018 Jul 07; 351(7):e1800050. PubMed ID: 29870588
    [Abstract] [Full Text] [Related]

  • 20. Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.
    Fernández-Bachiller MI, Pérez C, Campillo NE, Páez JA, González-Muñoz GC, Usán P, García-Palomero E, López MG, Villarroya M, García AG, Martínez A, Rodríguez-Franco MI.
    ChemMedChem; 2009 May 07; 4(5):828-41. PubMed ID: 19308922
    [Abstract] [Full Text] [Related]

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