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Journal Abstract Search

241 related items for PubMed ID: 25295702

  • 1. Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol.
    Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Vepsäläinen J, Pasanen M.
    Chem Res Toxicol; 2014 Nov 17; 27(11):1950-7. PubMed ID: 25295702
    [Abstract] [Full Text] [Related]

  • 2. Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine.
    Fashe MM, Juvonen RO, Petsalo A, Räsänen J, Pasanen M.
    Chem Res Toxicol; 2015 Oct 19; 28(10):2034-44. PubMed ID: 26395423
    [Abstract] [Full Text] [Related]

  • 3. New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro.
    Muluneh F, Häkkinen MR, El-Dairi R, Pasanen M, Juvonen RO.
    Rapid Commun Mass Spectrom; 2018 Aug 30; 32(16):1344-1352. PubMed ID: 29788543
    [Abstract] [Full Text] [Related]

  • 4. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
    Wang YP, Yan J, Fu PP, Chou MW.
    Toxicol Lett; 2005 Mar 15; 155(3):411-20. PubMed ID: 15649625
    [Abstract] [Full Text] [Related]

  • 5. In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.
    Fashe MM, Juvonen RO, Petsalo A, Vepsäläinen J, Pasanen M, Rahnasto-Rilla M.
    Chem Res Toxicol; 2015 Apr 20; 28(4):702-10. PubMed ID: 25651456
    [Abstract] [Full Text] [Related]

  • 6. 9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.
    Chen M, Li L, Zhong D, Shen S, Zheng J, Chen X.
    Chem Res Toxicol; 2016 Feb 15; 29(2):180-9. PubMed ID: 26761523
    [Abstract] [Full Text] [Related]

  • 7. Gas-phase fragmentation of the N-oxide and N-hydroxylated derivatives of retrorsine using liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
    Jahouh F, Marongiu F, Serra MP, Laconi E, Banoub J.
    Rapid Commun Mass Spectrom; 2015 Oct 15; 29(19):1733-48. PubMed ID: 26331923
    [Abstract] [Full Text] [Related]

  • 8. In vitro biotransformation of pyrrolizidine alkaloids in different species: part II-identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids.
    Geburek I, Schrenk D, These A.
    Arch Toxicol; 2020 Nov 15; 94(11):3759-3774. PubMed ID: 32880719
    [Abstract] [Full Text] [Related]

  • 9. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan 15; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

  • 10. Full structure assignments of pyrrolizidine alkaloid DNA adducts and mechanism of tumor initiation.
    Zhao Y, Xia Q, Gamboa da Costa G, Yu H, Cai L, Fu PP.
    Chem Res Toxicol; 2012 Sep 17; 25(9):1985-96. PubMed ID: 22857713
    [Abstract] [Full Text] [Related]

  • 11. Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid.
    Lin G, Cui YY, Hawes EM.
    Drug Metab Dispos; 1998 Feb 17; 26(2):181-4. PubMed ID: 9456306
    [Abstract] [Full Text] [Related]

  • 12. 1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids.
    He X, Xia Q, Gamboa da Costa G, Lin G, Fu PP.
    Chem Res Toxicol; 2019 Jun 17; 32(6):1193-1203. PubMed ID: 31120748
    [Abstract] [Full Text] [Related]

  • 13. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
    Xia Q, Yan J, Chou MW, Fu PP.
    Toxicol Lett; 2008 May 05; 178(2):77-82. PubMed ID: 18395999
    [Abstract] [Full Text] [Related]

  • 14. Prediction of biotransformation products of the fungicide fluopyram by electrochemistry coupled online to liquid chromatography-mass spectrometry and comparison with in vitro microsomal assays.
    Mekonnen TF, Panne U, Koch M.
    Anal Bioanal Chem; 2018 Apr 05; 410(10):2607-2617. PubMed ID: 29455286
    [Abstract] [Full Text] [Related]

  • 15. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct 05; 20(10):1488-97. PubMed ID: 17892269
    [Abstract] [Full Text] [Related]

  • 16. Metabolic activation of pyrrolizidine alkaloids by human, rat and avocado microsomes.
    Couet CE, Hopley J, Hanley AB.
    Toxicon; 1996 Sep 05; 34(9):1058-61. PubMed ID: 8896199
    [Abstract] [Full Text] [Related]

  • 17. Applying human and pig hepatic in vitro experiments for sulfur mustard study: screening and identification of metabolites by liquid chromatography/tandem mass spectrometry.
    Halme M, Pesonen M, Hakala U, Pasanen M, Vähäkangas K, Vanninen P.
    Rapid Commun Mass Spectrom; 2015 Jul 30; 29(14):1279-87. PubMed ID: 26405789
    [Abstract] [Full Text] [Related]

  • 18. Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.
    Winter CK, Segall HJ, Jones AD.
    Biomed Environ Mass Spectrom; 1988 Mar 01; 15(5):265-73. PubMed ID: 3365497
    [Abstract] [Full Text] [Related]

  • 19. Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo.
    Wang YP, Fu PP, Chou MW.
    Int J Environ Res Public Health; 2005 Apr 01; 2(1):74-9. PubMed ID: 16705803
    [Abstract] [Full Text] [Related]

  • 20. Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates.
    Tamta H, Pawar RS, Wamer WG, Grundel E, Krynitsky AJ, Rader JI.
    Xenobiotica; 2012 Oct 01; 42(10):1038-48. PubMed ID: 22519982
    [Abstract] [Full Text] [Related]

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