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290 related items for PubMed ID: 25313399

  • 1. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells.
    Xiao H, Bid HK, Jou D, Wu X, Yu W, Li C, Houghton PJ, Lin J.
    J Biol Chem; 2015 Feb 06; 290(6):3418-29. PubMed ID: 25313399
    [Abstract] [Full Text] [Related]

  • 2. A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells.
    Zhao C, Wang W, Yu W, Jou D, Wang Y, Ma H, Xiao H, Qin H, Zhang C, Lü J, Li S, Li C, Lin J, Lin L.
    Oncotarget; 2016 Mar 15; 7(11):12917-26. PubMed ID: 26883202
    [Abstract] [Full Text] [Related]

  • 3. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
    Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J.
    Neoplasia; 2010 Jan 15; 12(1):39-50. PubMed ID: 20072652
    [Abstract] [Full Text] [Related]

  • 4. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells.
    Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J.
    Cancer Sci; 2011 Jul 15; 102(7):1381-7. PubMed ID: 21435102
    [Abstract] [Full Text] [Related]

  • 5. Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma.
    Yu PY, Gardner HL, Roberts R, Cam H, Hariharan S, Ren L, LeBlanc AK, Xiao H, Lin J, Guttridge DC, Mo X, Bennett CE, Coss CC, Ling Y, Phelps MA, Houghton P, London CA.
    PLoS One; 2017 Jul 15; 12(7):e0181885. PubMed ID: 28750090
    [Abstract] [Full Text] [Related]

  • 6. LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells.
    Chen X, Pan L, Wei J, Zhang R, Yang X, Song J, Bai RY, Fu S, Pierson CR, Finlay JL, Li C, Lin J.
    Sci Rep; 2021 Mar 22; 11(1):6517. PubMed ID: 33753770
    [Abstract] [Full Text] [Related]

  • 7. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.
    Lin L, Benson DM, DeAngelis S, Bakan CE, Li PK, Li C, Lin J.
    Int J Cancer; 2012 Mar 15; 130(6):1459-69. PubMed ID: 21520044
    [Abstract] [Full Text] [Related]

  • 8. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.
    Yu W, Xiao H, Lin J, Li C.
    J Med Chem; 2013 Jun 13; 56(11):4402-12. PubMed ID: 23651330
    [Abstract] [Full Text] [Related]

  • 9. Suppression of STAT3 NH2 -terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de-repression by microRNA-21.
    Ray S, Coulter DW, Gray SD, Sughroue JA, Roychoudhury S, McIntyre EM, Chaturvedi NK, Bhakat KK, Joshi SS, McGuire TR, Sharp JG.
    Mol Carcinog; 2018 Apr 13; 57(4):536-548. PubMed ID: 29280516
    [Abstract] [Full Text] [Related]

  • 10. LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer.
    Pan L, Chen X, Fu S, Yu W, Li C, Wang T, Lo HW, Lin J.
    Breast Cancer Res Treat; 2020 May 13; 181(1):31-41. PubMed ID: 32240456
    [Abstract] [Full Text] [Related]

  • 11. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.
    Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J.
    PLoS One; 2012 May 13; 7(10):e46624. PubMed ID: 23056374
    [Abstract] [Full Text] [Related]

  • 12. Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways.
    Yang F, Jove V, Xin H, Hedvat M, Van Meter TE, Yu H.
    Mol Cancer Res; 2010 Jan 13; 8(1):35-45. PubMed ID: 20053726
    [Abstract] [Full Text] [Related]

  • 13. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.
    Ball S, Li C, Li PK, Lin J.
    PLoS One; 2011 Apr 19; 6(4):e18820. PubMed ID: 21526200
    [Abstract] [Full Text] [Related]

  • 14. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
    Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G.
    Br J Pharmacol; 2011 May 19; 163(2):283-98. PubMed ID: 21198544
    [Abstract] [Full Text] [Related]

  • 15. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway.
    Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z.
    BMC Cancer; 2010 May 10; 10():187. PubMed ID: 20459702
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma.
    Lau CK, Yang ZF, Lam SP, Lam CT, Ngai P, Tam KH, Poon RT, Fan ST.
    Cancer Biol Ther; 2007 Dec 10; 6(12):1900-7. PubMed ID: 18059167
    [Abstract] [Full Text] [Related]

  • 17. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
    Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB.
    Clin Cancer Res; 2007 May 15; 13(10):3024-32. PubMed ID: 17505005
    [Abstract] [Full Text] [Related]

  • 18. Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling.
    Wang Y, Ma H, Zhao C, Liu T, Yan D, Jou D, Li H, Zhang C, Lü J, Li C, Lin J, Li S, Lin L.
    Oncotarget; 2017 May 16; 8(20):33683-33693. PubMed ID: 28430601
    [Abstract] [Full Text] [Related]

  • 19. Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition.
    Wang YX, Cai H, Jiang G, Zhou TB, Wu H.
    Asian Pac J Cancer Prev; 2014 May 16; 15(16):6791-8. PubMed ID: 25169527
    [Abstract] [Full Text] [Related]

  • 20. STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma.
    Tu B, Du L, Fan QM, Tang Z, Tang TT.
    Cancer Lett; 2012 Dec 01; 325(1):80-8. PubMed ID: 22743617
    [Abstract] [Full Text] [Related]

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