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227 related items for PubMed ID: 25331949

  • 1. Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
    Izaguirre G, Aguila S, Qi L, Swanson R, Roth R, Rezaie AR, Gettins PG, Olson ST.
    J Biol Chem; 2014 Dec 05; 289(49):34049-64. PubMed ID: 25331949
    [Abstract] [Full Text] [Related]

  • 2. Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.
    Izaguirre G, Rezaie AR, Olson ST.
    J Biol Chem; 2009 Jan 16; 284(3):1550-8. PubMed ID: 19010776
    [Abstract] [Full Text] [Related]

  • 3. Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.
    Izaguirre G, Olson ST.
    J Biol Chem; 2006 May 12; 281(19):13424-13432. PubMed ID: 16517611
    [Abstract] [Full Text] [Related]

  • 4. Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin.
    Izaguirre G, Swanson R, Raja SM, Rezaie AR, Olson ST.
    J Biol Chem; 2007 Nov 16; 282(46):33609-33622. PubMed ID: 17875649
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  • 6. Localization of an antithrombin exosite that promotes rapid inhibition of factors Xa and IXa dependent on heparin activation of the serpin.
    Izaguirre G, Zhang W, Swanson R, Bedsted T, Olson ST.
    J Biol Chem; 2003 Dec 19; 278(51):51433-40. PubMed ID: 14532267
    [Abstract] [Full Text] [Related]

  • 7. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.
    Chuang YJ, Swanson R, Raja SM, Olson ST.
    J Biol Chem; 2001 May 04; 276(18):14961-71. PubMed ID: 11278930
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  • 9. Allosteric activation of antithrombin critically depends upon hinge region extension.
    Langdown J, Johnson DJ, Baglin TP, Huntington JA.
    J Biol Chem; 2004 Nov 05; 279(45):47288-97. PubMed ID: 15326167
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  • 10. Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.
    Bedsted T, Swanson R, Chuang YJ, Bock PE, Björk I, Olson ST.
    Biochemistry; 2003 Jul 15; 42(27):8143-52. PubMed ID: 12846563
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  • 11. Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation.
    Johnson DJ, Li W, Adams TE, Huntington JA.
    EMBO J; 2006 May 03; 25(9):2029-37. PubMed ID: 16619025
    [Abstract] [Full Text] [Related]

  • 12. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies.
    Rezaie AR, Olson ST.
    Biochemistry; 2000 Oct 03; 39(39):12083-90. PubMed ID: 11009624
    [Abstract] [Full Text] [Related]

  • 13. The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation.
    Chuang YJ, Swanson R, Raja SM, Bock SC, Olson ST.
    Biochemistry; 2001 Jun 05; 40(22):6670-9. PubMed ID: 11380262
    [Abstract] [Full Text] [Related]

  • 14. Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes.
    Futamura A, Beechem JM, Gettins PG.
    Biochemistry; 2001 Jun 05; 40(22):6680-7. PubMed ID: 11380263
    [Abstract] [Full Text] [Related]

  • 15. Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin.
    Rezaie AR, Yang L, Manithody C.
    Biochemistry; 2004 Mar 16; 43(10):2898-905. PubMed ID: 15005625
    [Abstract] [Full Text] [Related]

  • 16. Heparin-binding exosite of factor Xa.
    Rezaie AR.
    Trends Cardiovasc Med; 2000 Nov 16; 10(8):333-8. PubMed ID: 11369259
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  • 17. Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
    Johnson DJ, Langdown J, Huntington JA.
    Proc Natl Acad Sci U S A; 2010 Jan 12; 107(2):645-50. PubMed ID: 20080729
    [Abstract] [Full Text] [Related]

  • 18. The factor IXa heparin-binding exosite is a cofactor interactive site: mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin.
    Yuan QP, Walke EN, Sheehan JP.
    Biochemistry; 2005 Mar 08; 44(9):3615-25. PubMed ID: 15736971
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  • 20. Selective disruption of heparin and antithrombin-mediated regulation of human factor IX.
    Westmark PR, Tanratana P, Sheehan JP.
    J Thromb Haemost; 2015 Jun 08; 13(6):1053-63. PubMed ID: 25851619
    [Abstract] [Full Text] [Related]

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