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250 related items for PubMed ID: 25354695

  • 1. Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(-/-) mice.
    Campbell EJ, Vissers MC, Bozonet S, Dyer A, Robinson BA, Dachs GU.
    Cancer Med; 2015 Feb; 4(2):303-14. PubMed ID: 25354695
    [Abstract] [Full Text] [Related]

  • 2. Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice.
    Campbell EJ, Vissers MCM, Wohlrab C, Hicks KO, Strother RM, Bozonet SM, Robinson BA, Dachs GU.
    Free Radic Biol Med; 2016 Oct; 99():451-462. PubMed ID: 27567539
    [Abstract] [Full Text] [Related]

  • 3. Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate.
    Vissers MC, Gunningham SP, Morrison MJ, Dachs GU, Currie MJ.
    Free Radic Biol Med; 2007 Mar 15; 42(6):765-72. PubMed ID: 17320759
    [Abstract] [Full Text] [Related]

  • 4. Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer.
    Kuiper C, Molenaar IG, Dachs GU, Currie MJ, Sykes PH, Vissers MC.
    Cancer Res; 2010 Jul 15; 70(14):5749-58. PubMed ID: 20570889
    [Abstract] [Full Text] [Related]

  • 5. Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo-/- mice.
    Campbell EJ, Vissers MC, Dachs GU.
    Hypoxia (Auckl); 2016 Jul 15; 4():41-52. PubMed ID: 27800507
    [Abstract] [Full Text] [Related]

  • 6. Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor -1 alpha activity and reduce malignant potential in human melanoma.
    Fischer AP, Miles SL.
    Biomed Pharmacother; 2017 Feb 15; 86():502-513. PubMed ID: 28012930
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  • 9. Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells.
    Miles SL, Fischer AP, Joshi SJ, Niles RM.
    BMC Cancer; 2015 Nov 07; 15():867. PubMed ID: 26547841
    [Abstract] [Full Text] [Related]

  • 10. Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha.
    Vissers MC, Wilkie RP.
    J Leukoc Biol; 2007 May 07; 81(5):1236-44. PubMed ID: 17264304
    [Abstract] [Full Text] [Related]

  • 11. RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.
    Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu ZR, Jensen RL.
    J Neurosurg; 2015 Feb 07; 122(2):331-41. PubMed ID: 25423275
    [Abstract] [Full Text] [Related]

  • 12. Pharmacologic ascorbate (P-AscH-) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma.
    Wilkes JG, O'Leary BR, Du J, Klinger AR, Sibenaller ZA, Doskey CM, Gibson-Corley KN, Alexander MS, Tsai S, Buettner GR, Cullen JJ.
    Clin Exp Metastasis; 2018 Feb 07; 35(1-2):37-51. PubMed ID: 29396728
    [Abstract] [Full Text] [Related]

  • 13. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity.
    Jeong S, Park H, Hong S, Yum S, Kim W, Jung Y.
    Eur J Pharmacol; 2015 Jan 15; 747():114-22. PubMed ID: 25483211
    [Abstract] [Full Text] [Related]

  • 14. Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1α activation.
    Jung KH, Lee JH, Thien Quach CH, Paik JY, Oh H, Park JW, Lee EJ, Moon SH, Lee KH.
    J Nucl Med; 2013 Dec 15; 54(12):2161-7. PubMed ID: 24221993
    [Abstract] [Full Text] [Related]

  • 15. Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response.
    Kuiper C, Dachs GU, Currie MJ, Vissers MC.
    Free Radic Biol Med; 2014 Apr 15; 69():308-17. PubMed ID: 24495550
    [Abstract] [Full Text] [Related]

  • 16. The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines.
    Sinnberg T, Noor S, Venturelli S, Berger A, Schuler P, Garbe C, Busch C.
    J Cell Mol Med; 2014 Mar 15; 18(3):530-41. PubMed ID: 24330097
    [Abstract] [Full Text] [Related]

  • 17. Expression and/or activity of the SVCT2 ascorbate transporter may be decreased in many aggressive cancers, suggesting potential utility for sodium bicarbonate and dehydroascorbic acid in cancer therapy.
    McCarty MF.
    Med Hypotheses; 2013 Oct 15; 81(4):664-70. PubMed ID: 23916956
    [Abstract] [Full Text] [Related]

  • 18. Knockdown of hypoxia-inducible factor-1 alpha reduces proliferation, induces apoptosis and attenuates the aggressive phenotype of retinoblastoma WERI-Rb-1 cells under hypoxic conditions.
    Xia T, Cheng H, Zhu Y.
    Ann Clin Lab Sci; 2014 Oct 15; 44(2):134-44. PubMed ID: 24795051
    [Abstract] [Full Text] [Related]

  • 19. Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate.
    Jones DT, Trowbridge IS, Harris AL.
    Cancer Res; 2006 Mar 01; 66(5):2749-56. PubMed ID: 16510596
    [Abstract] [Full Text] [Related]

  • 20. Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice.
    Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.
    Exp Oncol; 2011 Dec 01; 33(4):226-30. PubMed ID: 22217712
    [Abstract] [Full Text] [Related]

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