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Journal Abstract Search

818 related items for PubMed ID: 25378907

  • 1. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
    Bautista-Aguilera OM, Esteban G, Chioua M, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Soriano E, Samadi A, Unzeta M, Marco-Contelles J.
    Drug Des Devel Ther; 2014; 8():1893-910. PubMed ID: 25378907
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
    Bautista-Aguilera OM, Esteban G, Bolea I, Nikolic K, Agbaba D, Moraleda I, Iriepa I, Samadi A, Soriano E, Unzeta M, Marco-Contelles J.
    Eur J Med Chem; 2014 Mar 21; 75():82-95. PubMed ID: 24530494
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I, Juárez-Jiménez J, de Los Ríos C, Chioua M, Pouplana R, Luque FJ, Unzeta M, Marco-Contelles J, Samadi A.
    J Med Chem; 2011 Dec 22; 54(24):8251-70. PubMed ID: 22023459
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Xie SS, Lan JS, Wang X, Wang ZM, Jiang N, Li F, Wu JJ, Wang J, Kong LY.
    Bioorg Med Chem; 2016 Apr 01; 24(7):1528-39. PubMed ID: 26917219
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
    Li F, Wang ZM, Wu JJ, Wang J, Xie SS, Lan JS, Xu W, Kong LY, Wang XB.
    J Enzyme Inhib Med Chem; 2016 Apr 01; 31(sup3):41-53. PubMed ID: 27384289
    [Abstract] [Full Text] [Related]

  • 6. Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
    Wang L, Esteban G, Ojima M, Bautista-Aguilera OM, Inokuchi T, Moraleda I, Iriepa I, Samadi A, Youdim MB, Romero A, Soriano E, Herrero R, Fernández Fernández AP, Ricardo-Martínez-Murillo, Marco-Contelles J, Unzeta M.
    Eur J Med Chem; 2014 Jun 10; 80():543-61. PubMed ID: 24813882
    [Abstract] [Full Text] [Related]

  • 7. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
    Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J.
    Eur J Med Chem; 2012 Jun 10; 52():251-62. PubMed ID: 22503231
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Sang Z, Pan W, Wang K, Ma Q, Yu L, Liu W.
    Bioorg Med Chem; 2017 Jun 15; 25(12):3006-3017. PubMed ID: 28487125
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
    Joubert J, Foka GB, Repsold BP, Oliver DW, Kapp E, Malan SF.
    Eur J Med Chem; 2017 Jan 05; 125():853-864. PubMed ID: 27744252
    [Abstract] [Full Text] [Related]

  • 10. Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.
    Pachón-Angona I, Refouvelet B, Andrýs R, Martin H, Luzet V, Iriepa I, Moraleda I, Diez-Iriepa D, Oset-Gasque MJ, Marco-Contelles J, Musilek K, Ismaili L.
    J Enzyme Inhib Med Chem; 2019 Dec 05; 34(1):479-489. PubMed ID: 30712420
    [Abstract] [Full Text] [Related]

  • 11. The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Zhu G, Wang K, Shi J, Zhang P, Yang D, Fan X, Zhang Z, Liu W, Sang Z.
    Bioorg Med Chem Lett; 2019 Oct 01; 29(19):126625. PubMed ID: 31444085
    [Abstract] [Full Text] [Related]

  • 12. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
    Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K.
    Eur J Med Chem; 2014 Jul 23; 82():426-38. PubMed ID: 24929293
    [Abstract] [Full Text] [Related]

  • 13. Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
    Samadi A, Estrada M, Pérez C, Rodríguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Marco-Contelles J.
    Eur J Med Chem; 2012 Nov 23; 57():296-301. PubMed ID: 23078965
    [Abstract] [Full Text] [Related]

  • 14. Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
    Xie SS, Wang X, Jiang N, Yu W, Wang KD, Lan JS, Li ZR, Kong LY.
    Eur J Med Chem; 2015 May 05; 95():153-65. PubMed ID: 25812965
    [Abstract] [Full Text] [Related]

  • 15. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    Wang ZM, Cai P, Liu QH, Xu DQ, Yang XL, Wu JJ, Kong LY, Wang XB.
    Eur J Med Chem; 2016 Nov 10; 123():282-297. PubMed ID: 27484514
    [Abstract] [Full Text] [Related]

  • 16. Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation.
    He Q, Liu J, Lan JS, Ding J, Sun Y, Fang Y, Jiang N, Yang Z, Sun L, Jin Y, Xie SS.
    Bioorg Chem; 2018 Dec 10; 81():512-528. PubMed ID: 30245233
    [Abstract] [Full Text] [Related]

  • 17. Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.
    Cai P, Fang SQ, Yang XL, Wu JJ, Liu QH, Hong H, Wang XB, Kong LY.
    ACS Chem Neurosci; 2017 Nov 15; 8(11):2496-2511. PubMed ID: 28806057
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
    Wang J, Wang ZM, Li XM, Li F, Wu JJ, Kong LY, Wang XB.
    Bioorg Med Chem; 2016 Sep 15; 24(18):4324-4338. PubMed ID: 27460699
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Lan JS, Ding Y, Liu Y, Kang P, Hou JW, Zhang XY, Xie SS, Zhang T.
    Eur J Med Chem; 2017 Oct 20; 139():48-59. PubMed ID: 28797883
    [Abstract] [Full Text] [Related]

  • 20. Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.
    Samadi A, Chioua M, Bolea I, de Los Ríos C, Iriepa I, Moraleda I, Bastida A, Esteban G, Unzeta M, Gálvez E, Marco-Contelles J.
    Eur J Med Chem; 2011 Sep 20; 46(9):4665-8. PubMed ID: 21669479
    [Abstract] [Full Text] [Related]

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