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551 related items for PubMed ID: 25430493

  • 1. Design, synthesis, and evaluation of non-ATP-competitive small-molecule Polo-like kinase 1 (Plk1) inhibitors.
    Chen DX, Huang J, Liu M, Xu YG, Jiang C.
    Arch Pharm (Weinheim); 2015 Jan; 348(1):2-9. PubMed ID: 25430493
    [Abstract] [Full Text] [Related]

  • 2. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors.
    Liu M, Huang J, Chen DX, Jiang C.
    Bioorg Med Chem Lett; 2015 Feb 01; 25(3):431-4. PubMed ID: 25556101
    [Abstract] [Full Text] [Related]

  • 3. Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.
    Shin SB, Woo SU, Yim H.
    J Cell Physiol; 2015 Dec 01; 230(12):3057-67. PubMed ID: 25975351
    [Abstract] [Full Text] [Related]

  • 4. Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.
    Mita Y, Noguchi-Yachide T, Ishikawa M, Hashimoto Y.
    Bioorg Med Chem; 2013 Feb 01; 21(3):608-17. PubMed ID: 23276450
    [Abstract] [Full Text] [Related]

  • 5. Aromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors.
    Sun J, Lv PC, Guo FJ, Wang XY, Xiao-Han, Zhang Y, Sheng GH, Qian SS, Zhu HL.
    Eur J Med Chem; 2014 Jun 23; 81():420-6. PubMed ID: 24859762
    [Abstract] [Full Text] [Related]

  • 6. Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase 1.
    Yun T, Qin T, Liu Y, Lai L.
    ChemMedChem; 2016 Apr 05; 11(7):713-7. PubMed ID: 27061239
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and biological evaluation of polo-like kinase 1/eukaryotic elongation factor 2 kinase (PLK1/EEF2K) dual inhibitors for regulating breast cancer cells apoptosis and autophagy.
    Pan Z, Chen Y, Liu J, Jiang Q, Yang S, Guo L, He G.
    Eur J Med Chem; 2018 Jan 20; 144():517-528. PubMed ID: 29288948
    [Abstract] [Full Text] [Related]

  • 8. Identification of novel, potent and selective inhibitors of Polo-like kinase 1.
    Chen S, Bartkovitz D, Cai J, Chen Y, Chen Z, Chu XJ, Le K, Le NT, Luk KC, Mischke S, Naderi-Oboodi G, Boylan JF, Nevins T, Qing W, Chen Y, Wovkulich PM.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1247-50. PubMed ID: 22172702
    [Abstract] [Full Text] [Related]

  • 9. Structure-based design and SAR development of novel selective polo-like kinase 1 inhibitors having the tetrahydropteridin scaffold.
    Lv X, Yang X, Zhan MM, Cao P, Zheng S, Peng R, Han J, Xie Z, Tu Z, Liao C.
    Eur J Med Chem; 2019 Dec 15; 184():111769. PubMed ID: 31629162
    [Abstract] [Full Text] [Related]

  • 10. Identification of a high affinity selective inhibitor of Polo-like kinase 1 for cancer chemotherapy by computational approach.
    Kumar M, Pydi SP, Sharma S, Singh TP, Kaur P.
    J Mol Graph Model; 2014 Jun 15; 51():104-12. PubMed ID: 24879322
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
    Johnson EF, Stewart KD, Woods KW, Giranda VL, Luo Y.
    Biochemistry; 2007 Aug 21; 46(33):9551-63. PubMed ID: 17655330
    [Abstract] [Full Text] [Related]

  • 12. In silico identification of putative bifunctional Plk1 inhibitors by integrative virtual screening and structural dynamics approach.
    Shafique S, Bibi N, Rashid S.
    J Theor Biol; 2016 Jan 07; 388():72-84. PubMed ID: 26493360
    [Abstract] [Full Text] [Related]

  • 13. Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1.
    Srinivasrao G, Park JE, Kim S, Ahn M, Cheong C, Nam KY, Gunasekaran P, Hwang E, Kim NH, Shin SY, Lee KS, Ryu E, Bang JK.
    PLoS One; 2014 Jan 07; 9(9):e107432. PubMed ID: 25211362
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and evaluation of d-amino acid-containing peptidomimetics targeting the polo-box domain of polo-like kinase 1.
    Li Z, Zhang Z, Chen Y, Tang S, Lin T, Huang J, Li B, Jiang C.
    Bioorg Chem; 2019 Apr 07; 85():534-540. PubMed ID: 30807896
    [Abstract] [Full Text] [Related]

  • 15. Identification of acylthiourea derivatives as potent Plk1 PBD inhibitors.
    Yun T, Qin T, Liu Y, Lai L.
    Eur J Med Chem; 2016 Nov 29; 124():229-236. PubMed ID: 27592392
    [Abstract] [Full Text] [Related]

  • 16. Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE.
    Craig SN, Baxter M, Chapagai D, Stafford JM, Nurmemmedov E, Altomare D, Wyatt MD, McInnes C.
    Eur J Med Chem; 2022 Jan 05; 227():113926. PubMed ID: 34735919
    [Abstract] [Full Text] [Related]

  • 17. Reaction-driven de novo design, synthesis and testing of potential type II kinase inhibitors.
    Schneider G, Geppert T, Hartenfeller M, Reisen F, Klenner A, Reutlinger M, Hähnke V, Hiss JA, Zettl H, Keppner S, Spänkuch B, Schneider P.
    Future Med Chem; 2011 Mar 05; 3(4):415-24. PubMed ID: 21452978
    [Abstract] [Full Text] [Related]

  • 18. Identification of green tea catechins as potent inhibitors of the polo-box domain of polo-like kinase 1.
    Shan HM, Shi Y, Quan J.
    ChemMedChem; 2015 Jan 05; 10(1):158-63. PubMed ID: 25196850
    [Abstract] [Full Text] [Related]

  • 19. Identification of nitroimidazole-oxime derivatives targeting the polo-box domain of polo-like kinase 1.
    Sun J, Liu HY, Xu RF, Zhu HL.
    Bioorg Med Chem; 2017 Dec 15; 25(24):6581-6588. PubMed ID: 29100732
    [Abstract] [Full Text] [Related]

  • 20. Designed inhibitor for nuclear localization signal of polo-like kinase 1 induces mitotic arrest.
    Chen F, Zhuo X, Qin T, Guo X, Zhang C, Lai L.
    Chem Biol Drug Des; 2017 May 15; 89(5):732-740. PubMed ID: 27882722
    [Abstract] [Full Text] [Related]

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