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Journal Abstract Search

328 related items for PubMed ID: 25451576

  • 1. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
    Shen Q, Zuo M, Ma L, Tian Y, Wang L, Jiang H, Zhou Q, Zhou H, Yu L, Zeng S.
    Chem Biol Interact; 2014 Dec 05; 224():89-99. PubMed ID: 25451576
    [Abstract] [Full Text] [Related]

  • 2. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile.
    Wang Y, Zhong D, Chen X, Zheng J.
    Chem Res Toxicol; 2009 May 05; 22(5):824-34. PubMed ID: 19358519
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  • 3. Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro.
    Paludetto MN, Kurkela M, Kahma H, Backman JT, Niemi M, Filppula AM.
    Drug Metab Dispos; 2023 Mar 05; 51(3):293-305. PubMed ID: 36446607
    [Abstract] [Full Text] [Related]

  • 4. Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A-mediated ortho-benzoquinone metabolite formation and glutathione depletion.
    Shi F, Zhao P, Li X, Pan H, Ma S, Ding L.
    J Appl Toxicol; 2015 Nov 05; 35(11):1372-80. PubMed ID: 25612170
    [Abstract] [Full Text] [Related]

  • 5. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
    Wen B, Chen Y, Fitch WL.
    Drug Metab Dispos; 2009 Jul 05; 37(7):1557-62. PubMed ID: 19364830
    [Abstract] [Full Text] [Related]

  • 6. In vitro and in vivo metabolic activation of berbamine to quinone methide intermediate.
    Sun Y, Yao T, Li H, Peng Y, Zheng J.
    J Biochem Mol Toxicol; 2017 Apr 05; 31(4):. PubMed ID: 27902864
    [Abstract] [Full Text] [Related]

  • 7. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct 05; 20(10):1488-97. PubMed ID: 17892269
    [Abstract] [Full Text] [Related]

  • 8. Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells.
    Jiang JZ, Yang BH, Ji LL, Yang L, Mao YC, Hu ZH, Wang ZT, Wang CH.
    Toxicol In Vitro; 2017 Feb 05; 38():59-66. PubMed ID: 27836570
    [Abstract] [Full Text] [Related]

  • 9. Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine.
    Beulz-Riché D, Grudé P, Puozzo C, Sautel F, Filaquier C, Riché C, Ratanasavanh D.
    Fundam Clin Pharmacol; 2005 Oct 05; 19(5):545-53. PubMed ID: 16176333
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  • 11. Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes.
    Han SY, Zhao HY, Zhou N, Zhou F, Li PP.
    J Ethnopharmacol; 2014 Oct 05; 151(1):210-7. PubMed ID: 24157377
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  • 13. Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.
    Natsui K, Mizuno Y, Tani N, Yabuki M, Komuro S.
    Eur J Drug Metab Pharmacokinet; 2007 Oct 05; 32(4):233-40. PubMed ID: 18348473
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  • 16. Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice.
    Jin H, Li L, Zhong D, Liu J, Chen X, Zheng J.
    Chem Res Toxicol; 2011 Dec 19; 24(12):2142-52. PubMed ID: 21992520
    [Abstract] [Full Text] [Related]

  • 17. Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
    Iida A, Sasaki E, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2015 Jul 19; 43(7):958-68. PubMed ID: 25870103
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  • 20. Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine.
    Wang RW, Liu L, Cheng H.
    Drug Metab Dispos; 1996 Jul 19; 24(7):786-91. PubMed ID: 8818577
    [Abstract] [Full Text] [Related]

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