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262 related items for PubMed ID: 25462536
1. Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples. Pierog P, Krishna M, Yamniuk A, Chauhan A, DeSilva B. J Immunol Methods; 2015 Jan; 416():124-36. PubMed ID: 25462536 [Abstract] [Full Text] [Related]
2. Evaluation of a generic immunoassay with drug tolerance to detect immune complexes in serum samples from cynomolgus monkeys after administration of human antibodies. Stubenrauch K, Wessels U, Essig U, Vogel R, Schleypen J. J Pharm Biomed Anal; 2010 Jun 05; 52(2):249-54. PubMed ID: 20083366 [Abstract] [Full Text] [Related]
3. A breakthrough novel method to resolve the drug and target interference problem in immunogenicity assays. Zoghbi J, Xu Y, Grabert R, Theobald V, Richards S. J Immunol Methods; 2015 Nov 05; 426():62-9. PubMed ID: 26255760 [Abstract] [Full Text] [Related]
4. Detection of low-affinity anti-drug antibodies and improved drug tolerance in immunogenicity testing by Octet(®) biolayer interferometry. Li J, Schantz A, Schwegler M, Shankar G. J Pharm Biomed Anal; 2011 Jan 25; 54(2):286-94. PubMed ID: 20869832 [Abstract] [Full Text] [Related]
5. Epitope characterization of the ADA response directed against a targeted immunocytokine. Stubenrauch K, Künzel C, Vogel R, Tuerck D, Schick E, Heinrich J. J Pharm Biomed Anal; 2015 Oct 10; 114():296-304. PubMed ID: 26093509 [Abstract] [Full Text] [Related]
6. The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance. Opolka-Hoffmann E, Jordan G, Otteneder M, Kieferle R, Lechmann M, Winter G, Staack RF. MAbs; 2021 Oct 10; 13(1):1995929. PubMed ID: 34763611 [Abstract] [Full Text] [Related]
9. Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development. Carrasco-Triguero M, Davis H, Zhu Y, Coleman D, Nazzal D, Vu P, Kaur S. J Immunol Res; 2016 Oct 10; 2016():2618575. PubMed ID: 27092313 [Abstract] [Full Text] [Related]
10. Restricted immune activation and internalisation of anti-idiotype complexes between drug and antidrug antibodies. van Schie KA, Kruithof S, Ooijevaar-de Heer P, Derksen NIL, van de Bovenkamp FS, Saris A, Vidarsson G, Bentlage AEH, Jiskoot W, Romeijn S, Koning RI, Bos E, Stork EM, Koeleman CAM, Wuhrer M, Wolbink G, Rispens T. Ann Rheum Dis; 2018 Oct 10; 77(10):1471-1479. PubMed ID: 29945923 [Abstract] [Full Text] [Related]
11. Quantification of a bifunctional drug in the presence of an immune response: a ligand-binding assay specific for 'active' drug. Staack RF, Jordan G, Viert M, Schäfer M, Papadimitriou A, Heinrich J. Bioanalysis; 2015 Dec 10; 7(24):3097-106. PubMed ID: 26484402 [Abstract] [Full Text] [Related]
12. Immunogenicity screening assay development for a novel human-mouse chimeric anti-CD147 monoclonal antibody (Metuzumab). Mi L, Li W, Li M, Chen T, Wang M, Sun L, Chen Z. J Immunol Methods; 2016 Jun 10; 433():38-43. PubMed ID: 26944771 [Abstract] [Full Text] [Related]
13. A novel method for the detection of antibodies to adalimumab in the presence of drug reveals "hidden" immunogenicity in rheumatoid arthritis patients. van Schouwenburg PA, Bartelds GM, Hart MH, Aarden L, Wolbink GJ, Wouters D. J Immunol Methods; 2010 Oct 31; 362(1-2):82-8. PubMed ID: 20833178 [Abstract] [Full Text] [Related]
14. Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies. Hoffmann E, Jordan G, Lauer M, Ringler P, Kusznir EA, Rufer AC, Huber S, Jochner A, Winter G, Staack RF. Pharm Res; 2019 Jun 28; 36(9):129. PubMed ID: 31254106 [Abstract] [Full Text] [Related]
15. Pharmacokinetics and immunogenicity investigation of a human anti-interleukin-17 monoclonal antibody in non-naïve cynomolgus monkeys. Han C, Gunn GR, Marini JC, Shankar G, Han Hsu H, Davis HM. Drug Metab Dispos; 2015 May 28; 43(5):762-70. PubMed ID: 25739974 [Abstract] [Full Text] [Related]
16. Detection of antibodies against therapeutic proteins in the presence of residual therapeutic protein using a solid-phase extraction with acid dissociation (SPEAD) sample treatment prior to ELISA. Smith HW, Butterfield A, Sun D. Regul Toxicol Pharmacol; 2007 Dec 28; 49(3):230-7. PubMed ID: 17869396 [Abstract] [Full Text] [Related]
17. A method combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem-mass spectrometry to detect circulating immune complexes between therapeutic monoclonal antibodies and anti-drug antibodies in animals. Kobayashi K, Tahara H, Kagawa Y. J Pharm Biomed Anal; 2020 Jul 15; 186():113329. PubMed ID: 32371323 [Abstract] [Full Text] [Related]
18. SEC Based Method for Size Determination of Immune Complexes of Therapeutic Antibodies in Animal Matrix. Boysen M, Schlicksupp L, Dreher I, Loebbert R, Richter M. J Immunol Res; 2016 Jul 15; 2016():9096059. PubMed ID: 27556050 [Abstract] [Full Text] [Related]