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839 related items for PubMed ID: 25500798

  • 1. The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.
    Batelli S, Invernizzi RW, Negro A, Calcagno E, Rodilossi S, Forloni G, Albani D.
    Neurodegener Dis; 2015; 15(1):13-23. PubMed ID: 25500798
    [Abstract] [Full Text] [Related]

  • 2. The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease.
    Sharma N, Rao SP, Kalivendi SV.
    Free Radic Biol Med; 2019 May 01; 135():28-37. PubMed ID: 30796974
    [Abstract] [Full Text] [Related]

  • 3. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model.
    Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, Yanagisawa D, Nishimura K, Taniguchi T, Kiso Y, Yoshimoto K, Agatsuma T, Koide-Yoshida S, Iguchi-Ariga SM, Shimohama S, Ariga H.
    Neurobiol Dis; 2006 Oct 01; 24(1):144-58. PubMed ID: 16860563
    [Abstract] [Full Text] [Related]

  • 4. DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.
    Batelli S, Albani D, Rametta R, Polito L, Prato F, Pesaresi M, Negro A, Forloni G.
    PLoS One; 2008 Apr 02; 3(4):e1884. PubMed ID: 18382667
    [Abstract] [Full Text] [Related]

  • 5. DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.
    Ramsey CP, Tsika E, Ischiropoulos H, Giasson BI.
    Hum Mol Genet; 2010 Apr 15; 19(8):1425-37. PubMed ID: 20089532
    [Abstract] [Full Text] [Related]

  • 6. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.
    Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, Lee VM, Sortwell CE.
    Neurobiol Dis; 2015 Oct 15; 82():185-199. PubMed ID: 26093169
    [Abstract] [Full Text] [Related]

  • 7. DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.
    Lev N, Barhum Y, Pilosof NS, Ickowicz D, Cohen HY, Melamed E, Offen D.
    J Gerontol A Biol Sci Med Sci; 2013 Mar 15; 68(3):215-25. PubMed ID: 22887838
    [Abstract] [Full Text] [Related]

  • 8. alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.
    Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P.
    Proc Natl Acad Sci U S A; 2002 Aug 06; 99(16):10813-8. PubMed ID: 12122208
    [Abstract] [Full Text] [Related]

  • 9. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease.
    Takahashi-Niki K, Inafune A, Michitani N, Hatakeyama Y, Suzuki K, Sasaki M, Kitamura Y, Niki T, Iguchi-Ariga SM, Ariga H.
    J Pharmacol Sci; 2015 Mar 06; 127(3):305-10. PubMed ID: 25837927
    [Abstract] [Full Text] [Related]

  • 10. Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.
    Inden M, Kitamura Y, Takahashi K, Takata K, Ito N, Niwa R, Funayama R, Nishimura K, Taniguchi T, Honda T, Taira T, Ariga H.
    J Pharmacol Sci; 2011 Mar 06; 117(3):189-203. PubMed ID: 22041943
    [Abstract] [Full Text] [Related]

  • 11. Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice.
    Pavia-Collado R, Cóppola-Segovia V, Miquel-Rio L, Alarcón-Aris D, Rodríguez-Aller R, Torres-López M, Paz V, Ruiz-Bronchal E, Campa L, Artigas F, Montefeltro A, Revilla R, Bortolozzi A.
    Int J Mol Sci; 2021 Mar 13; 22(6):. PubMed ID: 33805843
    [Abstract] [Full Text] [Related]

  • 12. Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model.
    Jeong HJ, Kim DW, Woo SJ, Kim HR, Kim SM, Jo HS, Park M, Kim DS, Kwon OS, Hwang IK, Han KH, Park J, Eum WS, Choi SY.
    Mol Cells; 2012 May 13; 33(5):471-8. PubMed ID: 22526393
    [Abstract] [Full Text] [Related]

  • 13. DJ-1 deficiency impairs autophagy and reduces alpha-synuclein phagocytosis by microglia.
    Nash Y, Schmukler E, Trudler D, Pinkas-Kramarski R, Frenkel D.
    J Neurochem; 2017 Dec 13; 143(5):584-594. PubMed ID: 28921554
    [Abstract] [Full Text] [Related]

  • 14. A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.
    Lev N, Barhum Y, Ben-Zur T, Aharony I, Trifonov L, Regev N, Melamed E, Gruzman A, Offen D.
    PLoS One; 2015 Dec 13; 10(5):e0127549. PubMed ID: 26024237
    [Abstract] [Full Text] [Related]

  • 15. DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.
    Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF.
    Cell Death Dis; 2014 Jul 24; 5(7):e1350. PubMed ID: 25058424
    [Abstract] [Full Text] [Related]

  • 16. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.
    Sun SY, An CN, Pu XP.
    Brain Res Bull; 2012 Sep 01; 88(6):609-16. PubMed ID: 22664331
    [Abstract] [Full Text] [Related]

  • 17. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
    Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D.
    J Neurosci; 2016 Jul 20; 36(29):7693-706. PubMed ID: 27445146
    [Abstract] [Full Text] [Related]

  • 18. α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.
    Harischandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG.
    Toxicol Sci; 2015 Feb 20; 143(2):454-68. PubMed ID: 25416158
    [Abstract] [Full Text] [Related]

  • 19. Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease.
    Lehmensiek V, Tan EM, Liebau S, Lenk T, Zettlmeisl H, Schwarz J, Storch A.
    Neurochem Int; 2006 Apr 20; 48(5):329-40. PubMed ID: 16406146
    [Abstract] [Full Text] [Related]

  • 20. Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model.
    Behere A, Thörnqvist PO, Winberg S, Ingelsson M, Bergström J, Ekmark-Lewén S.
    J Neurosci Res; 2021 Oct 20; 99(10):2525-2539. PubMed ID: 34292621
    [Abstract] [Full Text] [Related]

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